A5064368467- Epigenetics and DNA Methylation
- Genomics and Chromatin Dynamics
- MicroRNA in disease regulation
- Pluripotent Stem Cells Research
- Venous Thromboembolism Diagnosis and Management
- Acute Myocardial Infarction Research
- RNA modifications and cancer
- RNA Research and Splicing
- Genetic Neurodegenerative Diseases
- Immune Cell Function and Interaction
- Renal and related cancers
- Immune cells in cancer
- Immune responses and vaccinations
- Cytomegalovirus and herpesvirus research
- Glioma Diagnosis and Treatment
- T-cell and B-cell Immunology
- Diagnosis and Treatment of Venous Diseases
- Liver Disease Diagnosis and Treatment
MRC Weatherall Institute of Molecular Medicine
2024-2025
University of Oxford
2024-2025
Maimonides Medical Center
2025
Hebrew University of Jerusalem
2019-2024
Edmond and Lily Safra Children's Hospital
2019
Abstract Cytomegalovirus (CMV) is a globally endemic latent herpes virus that profoundly impacts T cell immunity. We investigated the oncological consequences of CMV infection across 341 prospectively recruited patients receiving immune checkpoint blockade (ICB) for melanoma. + with metastatic melanoma (MM) have higher lymphocyte counts, reduced neutrophil to ratio and divergent CD8 gene expression. Combination anti-CTLA-4/anti-PD-1 ICB, but not single-agent anti-PD-1 induces cytotoxicity...
Abstract The histone H3 variant, H3.3, is localized at specific regions in the genome, especially promoters and active enhancers, has been shown to play important roles development. A lysine methionine substitution position 27 (H3.3K27M) a main cause of Diffuse Intrinsic Pontine Glioma (specifically Midline Glioma, K27M-mutant), lethal type pediatric cancer. H3.3K27M dominant-negative effect by inhibiting Polycomb Repressor Complex 2 (PRC2) activity. Here, we studied immediate, genome-wide,...
Abstract The human genome contains dozens of genes that encode for proteins containing long poly-glutamine repeats (polyQ, usually encoded by CAG codons) 10Qs or more. However, only nine these have been reported to expand beyond the healthy variation and cause diseases. To address whether disease-associated are unique in any way, we compared genetic epigenetic features relative other types genes, especially repeat do not Our analyses show pluripotent cells, polyQ disease-related...