A5061931768- Alzheimer's disease research and treatments
- Nuclear Receptors and Signaling
- Cholinesterase and Neurodegenerative Diseases
- Computational Drug Discovery Methods
- GDF15 and Related Biomarkers
- Neurological Disease Mechanisms and Treatments
- Sleep and Wakefulness Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Obstructive Sleep Apnea Research
- MicroRNA in disease regulation
- Neuroscience of respiration and sleep
- Neurological Disorders and Treatments
- Restless Legs Syndrome Research
- Peripheral Neuropathies and Disorders
- Anesthesia and Neurotoxicity Research
- Lipoproteins and Cardiovascular Health
- Moyamoya disease diagnosis and treatment
- Neurological disorders and treatments
- RNA regulation and disease
- Antiplatelet Therapy and Cardiovascular Diseases
- Metabolism and Genetic Disorders
- Sleep and related disorders
- Tryptophan and brain disorders
- Myasthenia Gravis and Thymoma
- bioluminescence and chemiluminescence research
China XD Group (China)
2023
Air Force Medical University
2008-2019
Stony Brook University
2005-2006
Oklahoma Medical Research Foundation
2005
Objective Growing evidence indicates that the activation of c‐Jun N‐terminal kinase (JNK) is implicated in multiple major pathological features Alzheimer disease (AD). However, whether specific inhibition JNK could prevent progression adult transgenic AD models at moderate stage remains unknown. Here we first investigated potential disease‐modifying therapeutic effect systemic administration SP600125, a small‐molecule JNK‐specific inhibitor, middle‐aged APPswe/PS1dE9 mice. Methods Using...
Alzheimer's disease (AD) is the most common cause of dementia. Amyloid β (Abeta, Aβ) deposition and intracellular tangles are pathological hallmarks AD. MicroRNAs (miRNAs) small non-coding RNAs, which have been found to play very important roles, potential serve as diagnostic markers during neuronal pathogenesis. In this study, we aimed determine roles miR-99b-5p miR-100-5p in Aβ-induced pathologies. We detected expression levels brains APPswe/PS1ΔE9 double-transgenic mice (APP/PS1 mice) at...
MicroRNAs are small non-coding RNAs that repress the expression of their target proteins. The roles microRNAs in development Alzheimer's disease (AD) not clear. In this study we show miR-200c represses PTEN protein. downregulation by supports survival and differentiation cultured neurons. AD is a progressive neurodegenerative signified beta amyloid (Aβ) peptide aggregation deposition. mouse model induced APPswe PS1ΔE9 double transgenes, found Aβ deposition results neuronal ER stress induces...
Cerebral microvascular amyloid-β (Aβ) protein deposition is emerging as an important contributory factor to neuroinflammation and dementia in Alzheimer's disease related familial cerebral amyloid angiopathy disorders. In particular, deposition, but not parenchymal amyloid, more often correlated with dementia. Recently, we generated transgenic mice ( Tg-SwDI ) expressing the vasculotropic Dutch (E693Q)/Iowa (D694N) mutant human Aβ precursor brain that accumulate abundant fibrillar deposits....
Background and Purpose Chronic cerebral hypoperfusion is a critical causative factor for the development of cognitive decline dementia in elderly, which involves many pathophysiological processes. Consequently, inhibition several pathways an attractive therapeutic strategy this disorder. Rutin, biologically active flavonoid, protects brain against insults through its antioxidant anti‐inflammatory properties, but effect on deficits damage caused by chronic remains unknown. Here, we...
The amyloid β-protein precursor (AβPP) is best known as the parent molecule to β-peptide that accumulates in brains of patients with Alzheimer's disease. Secreted isoforms AβPP contain Kunitz proteinase inhibitor domain are analogous previously identified cell-secreted protease nexin-2 (PN2). Although PN2/AβPP enriched brain and circulating blood platelets, little understood its physiological function potential role disease processes outside generation. We hypothesized potent inhibition...
Alzheimer's disease (AD) is the most common cause of dementia. One pathological hallmarks AD amyloid β (Aβ) deposition. MicroRNAs (miRNAs) are small non-coding RNAs whose expression levels change significantly during neuronal pathogenesis and may be used as diagnostic markers. Some miRNAs important in development by targeting genes responsible for Aβ metabolism. However, a systematic assessment miRNA profile induced Aβ-mediated still lacking. In present study, we examined using APPswe/PS1ΔE9...
Background The pathogenesis of extraocular muscle (EOM) weakness in myasthenia gravis might involve a mechanism specific to the EOM. aim this study was investigate characteristics EOM related its susceptibility gravis. Methods Female F344 rats and female Sprague-Dawley were assigned experimental control groups. group received injection with Ringer solution containing monoclonal antibody against acetylcholine receptor (AChR), mAb35 (0.25 mg/kg), induce autoimmune gravis, alone. Three muscles...