A5061310202- High Altitude and Hypoxia
- Ferroptosis and cancer prognosis
- Exercise and Physiological Responses
- RNA modifications and cancer
- Physical Education and Training Studies
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Physical Activity and Health
- MicroRNA in disease regulation
- Gestational Diabetes Research and Management
- Autophagy in Disease and Therapy
- Cancer, Hypoxia, and Metabolism
- Pulmonary Hypertension Research and Treatments
- Aortic aneurysm repair treatments
- Cardiovascular and exercise physiology
- Vitamin C and Antioxidants Research
- Cancer-related gene regulation
- Sports Performance and Training
- Aortic Disease and Treatment Approaches
- Hydrogen's biological and therapeutic effects
- Lipid metabolism and disorders
- Diet and metabolism studies
- Cardiovascular Function and Risk Factors
- Pregnancy-related medical research
- Dietary Effects on Health
Tang Du Hospital
2024-2025
Beijing Sport University
2014-2025
Dalian Medical University
2025
Second Affiliated Hospital of Dalian Medical University
2025
Army Medical University
2025
Chongqing Medical University
2025
Second Affiliated Hospital of Chongqing Medical University
2025
Tongji Hospital
2018-2024
Huazhong University of Science and Technology
2017-2024
Air Force Medical University
2016-2024
Smooth muscle cell (SMC) loss is the characteristic feature in pathogenesis of aortic dissection (AD), and ferroptosis a novel iron-dependent regulated death driven by excessive lipid peroxidation accumulation. However, whether targeting an effective approach for SMC AD treatment remains unclear. Here, we found that iron level, ferroptosis-related molecules TFR, HOMX1, ferritin product 4-hydroxynonenal were increased aorta AD. Then, screened several inhibitors histone methyltransferases...
Excessive nuclear factor-κB (NF-κB) activation mediated by tumor necrosis factor α (TNFα) plays a critical role in inflammation. Here we demonstrate that angiopoietin-like 8 (ANGPTL8) functions as negative feedback regulator TNFα-triggered NF-κB intracellularly. Inflammatory stimuli induce ANGPTL8 expression, and knockdown or knockout of potentiates TNFα-induced vitro. Mechanistically, upon TNFα stimulation, facilitates the interaction IKKγ with p62 via forming complex, thus promoting...
Previous studies have shown that ferroptosis of vascular smooth muscle cells (VSMCs) is involved in the development aortic dissection (AD) and histone methylation regulates this process. SP2509 acts as a specific inhibitor lysine-specific demethylase 1 (LSD1), which governs variety biological processes. However, effect on VSMC AD remains to be elucidated. This aim study was investigate role underlying mechanism SP2509-mediated ferroptosis. Here, mouse model established, significantly reduced...
Abstract Enhancer of zeste homolog 2 (EZH2), a methyltransferase that di- and tri-methylates lysine-27 histone H3, largely functions as transcriptional repressor, plays critical role in various kinds cancers. Here we report novel function EZH2 regulating autophagic cell death (ACD) vascular smooth muscle cells (VSMCs) affect aortic dissection (AD). Inhibition activity by UNC1999 or knockdown resulted VSMC loss, while overexpression facilitated growth, these effects on VSMCs were independent...
Although EHMT2 (also known as G9a) plays a critical role in several kinds of cancers and cardiac remodeling, its function vascular smooth muscle cells (VSMCs) remains unknown.In the present study, we revealed novel regulating autophagic cell death (ACD) VSMC.Inhibition by BIX01294 or knockdown resulted reduced VSMC numbers which were independent proliferation apoptosis.Interestingly, protein levels significantly decreased VSMCs treated with inducers.Moreover, more vacuoles accumulated LC3II...
Hyperproliferation of pulmonary arterial smooth muscle cells (PASMCs) and consequent vascular remodeling are the crucial pathological features hypertension (PH). Protein methylation has been shown to be critically involved in PASMC proliferation PH, but underlying mechanism remains largely unknown.
The pathological features of aortic dissection (AD) include vascular smooth muscle cell (VSMC) loss, elastic fiber fraction, and inflammatory responses in the aorta. However, little is known about post-translational modification mechanisms responsible for these biological processes. A total 72 aorta samples, used protein detection, were collected from 36 coronary artery disease (CAD, served as control) patients type AD (TAAD) patients. Chromatin immunoprecipitation (ChIP)-PCR was to identify...
This study examined the effectiveness of Tai-Chi and running exercises on cardiorespiratory fitness biomarkers in sedentary middle-aged adults under 24 weeks supervised training. Methods Thirty-six healthy (55.6 ± 5.3 yr) were randomly assigned into Tai-Chi, control groups. During a 24-week training period, groups asked to perform for 60 min/day 5 days/week, which by instructors throughout. Resting heart rate, lean mass, blood pressure lipids measured, (VO2max, Vmax Peak rate) was assessed...
Dietary calcium supplements can prevent osteoporosis, and our previous investigation demonstrated a notable increase in duodenal absorption due to the impact of estrogen. The decrease estrogen level postmenopausal women is significantly associated with an increased incidence osteoporosis. In this study, we further investigated role regulating osteoporosis elucidated its underlying molecular mechanism. We recruited ten young prefollicular stage menopausal for study. Furthermore, performed...
The aim of this study was to investigate the effect a 16/8 time-restricted eating (TRE) program over 6 weeks on body composition and lipolytic hormone levels in female DanceSport dancers. Importantly, participants were not subject any calorie restrictions during period. A total 20 dancers recruited participate randomized controlled trial. randomly assigned either group (TRE, n = 10) or control (n 10). TRE adhered protocol for period six weeks, consuming food within an eight-hour window...
Thoracic aortic aneurysm (TAA) is a life-threatening cardiovascular disease whose formation reported to be associated with massive vascular inflammatory responses. To elucidate the roles of immune cell infiltration in pathogenesis underlying TAA, we utilized multiple TAA datasets (microarray data and scRNA-seq data) various immune-related algorithms (ssGSEA, CIBERSORT, Seurat) reveal landscapes microenvironment TAA. The results exhibited significant increase macrophages T cells, which were...
Purpose: Stress urinary incontinence (SUI) refers to involuntary leakage from the urethra, synchronous with exertion/effort, sneezing or coughing, which has a negative effect on quality of life. Studies have shown that mild-to-moderate physical activities reduce risk SUI by multiple mechanisms. The objective this study was determine whether Rumba dance combined breathing training (RDBT) can severity and improve life patients SUI. Methods: A randomized clinical trial conducted women who were...
Filamins (FLNs) are actin cross-linking proteins, and as scaffolding FLNs closely associated with the stabilization of cytoskeleton. Nevertheless, biological importance in aortic dissection (AD) has not been well-elucidated. In this study, we first reanalyzed datasets downloaded from Gene Expression Omnibus (GEO) database, found that addition to extracellular matrix, cytoskeleton is a key structure AD. Given involved remodeling affect cellular functions, measured their expression levels...
Abnormal proliferation of pulmonary artery smooth muscle cells (PASMCs) is a critical pathological feature in the pathogenesis arterial hypertension (PAH), but regulatory mechanisms remain largely unknown. Herein, we demonstrated that interferon factor 9 (IRF9) accelerated PASMCs by regulating Prohibitin 1 (PHB1) expression and AKT-GSK3β signaling pathway. Compared with control groups, rats treated chronic hypoxia (CH), monocrotaline (MCT) or sugen5416 combined (SuHx), mice challenged CH had...
Coronary restenosis is an important cause of poor long-term prognosis in patients with coronary heart disease. Here, we show that lysine methyltransferase SMYD2 expression the nucleus significantly elevated serum- and PDGF-BB-induced vascular smooth muscle cells (VSMCs), tissues carotid artery injury-induced neointimal hyperplasia. Smyd2 overexpression VSMCs (Smyd2-vTg) facilitates, but treatment its specific inhibitor LLY-507 or knockdown inhibits VSMC phenotypic switching neointima...
Abnormal proliferation of pulmonary artery smooth muscle cells (PASMCs) is one the critical pathological mechanisms hypertension (PH), and therefore gradually being adopted as an important direction for treatment PH. Metallothioneins (MTs) have been reported to be associated with PH, but underlying are not fully understood. Here, we demonstrated that expression level metallothionein 3 (MT3) was significantly increased in arterioles from PH patients chronic hypoxia-induced rat mouse models,...