A5019115247- Drug Transport and Resistance Mechanisms
- Cholesterol and Lipid Metabolism
- Gallbladder and Bile Duct Disorders
- Liver Disease Diagnosis and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Diet, Metabolism, and Disease
- Helicobacter pylori-related gastroenterology studies
- Diabetes Treatment and Management
- Pancreatitis Pathology and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Peroxisome Proliferator-Activated Receptors
- Diet and metabolism studies
- Estrogen and related hormone effects
- Neuropeptides and Animal Physiology
- Biliary and Gastrointestinal Fistulas
- Phytase and its Applications
- Drug-Induced Hepatotoxicity and Protection
- Regulation of Appetite and Obesity
- Liver Disease and Transplantation
- Trace Elements in Health
- Digestive system and related health
- Endoplasmic Reticulum Stress and Disease
- Garlic and Onion Studies
- Liver physiology and pathology
- Lipid metabolism and biosynthesis
Albert Einstein College of Medicine
2017-2023
Saint Louis University
2011-2020
GTx (United States)
2005-2017
University of Bari Aldo Moro
2017
Beth Israel Deaconess Medical Center
2003-2016
Harvard University
2003-2016
University of Genoa
2016
Brigham and Women's Hospital
1998-2014
UCLouvain Saint-Louis Brussels
2011-2013
Harvard University Press
2001-2009
The primary bile acids (BAs) are synthetized from cholesterol in the liver, conjugated to glycine or taurine increase their solubility, secreted into bile, concentrated gallbladder during fasting, and expelled intestine response dietary fat. BAs also bio-transformed colon secondary by gut microbiota, reabsorbed ileum back minimally lost feces. not only regulate digestion absorption of cholesterol, triglycerides, fat-soluble vitamins, but play a key role as signaling molecules modulating...
Atherosclerosis is characterized by lipid accumulation, inflammatory response, cell death and fibrosis in the arterial wall, a major pathological basis for ischemic coronary heart disease (CHD), which leading cause of morbidity mortality USA Europe. Intervention studies with statins have shown to reduce plasma LDL cholesterol concentrations subsequently risk developing CHD. However, not all aggressive statin therapy could decrease Many clinical epidemiological clearly demonstrated that HDL...
We explored the influence of hydrophilic-hydrophobic balance a series natural bile acids on cholesterol absorption in mouse. Male C57L/J mice were fed standard chow or supplemented with 0.5% cholic; chenodeoxycholic; deoxycholic; dehydrocholic; hyocholic; hyodeoxycholic; α-, β-, ω-muricholic; ursocholic; ursodeoxycholic for 7 days. Biliary salts measured by reverse-phase HPLC, and hydrophobicity indices estimated Heuman's method. Cholesterol efficiency was determined plasma dual-isotope...
Abstract Bile secretion is essential for whole body sterol homeostasis. Loss‐of‐function mutations in specific canalicular transporters the hepatocyte disrupt bile flow and result cholestasis. We show that two of these transporters, ABCB11 ATP8B1, are functional targets miR‐33, a micro‐RNA expressed from within an intron SREBP‐2 . Consequently, manipulation miR‐33 levels vivo with adenovirus or antisense oligonucleotides results changes recovery gallbladder. Using radiolabelled cholesterol,...
Primary hepatocyte culture is a valuable tool that has been extensively used in basic research of liver function, disease, pathophysiology, pharmacology and other related subjects. The method based on two-step collagenase perfusion for isolation intact hepatocytes was first introduced by Berry Friend 1969 1 and, since then, undergone many modifications. most commonly technique described Seglenin 1976 2. Essentially, are dissociated from anesthetized adult rats non-recirculating through the...
Ginsenoside Rb1 (Rb1), a natural compound extracted from ginseng, exerts anti-obesity activity and improves insulin sensitivity in high-fat diet (HFD)-induced obese rats. The objective of the current study was to evaluate protective effect on fatty liver HFD-induced rats elucidate underlying mechanisms. After chronic intraperitoneal administration, (10 mg/kg) significantly ameliorated hepatic fat accumulation rats, as demonstrated by reduced weight, triglyceride content, histological...
Bile acids (BAs) regulate the absorption of fat-soluble vitamins, cholesterol and lipids but have also a key role as signaling molecules in modulation epithelial cell proliferation, gene expression metabolism. These homeostatic pathways, when disrupted, are able to promote local inflammation, systemic metabolic disorders and, ultimately, cancer. The effect hydrophobic BAs, particular, can be linked with cancer several digestive (mainly oesophagus, stomach, liver, pancreas, biliary tract,...
Sweet cherry (Prunus avium L.) is one of the most popular and appreciated temperate fruit not only for its sensory nutritional properties, but also content in bioactive compounds. Consumption sweet cherries brings beneficial effects on to health, which include prevention modulatory several chronic diseases such as (diabetes mellitus, cancer, cardiovascular other inflammatory diseases). The presence natural polyphenolic compounds with high antioxidant potential might drive partly explain...