The ubiquitous presence of Microplastics (MPs) in various environments documented recent years has recently raised significant concerns about their toxic effects. While macrophages serve as the first line defense against substances and pathogens, impact mechanisms microplastics on these immune cells remain unclear. This study aims to explore whether MPs induce macrophage apoptosis through promotion reactive oxygen species (ROS) generation alterations metabolic profiles. viability RAW264.7...

Microplastics (MPs) and tributyltin (TBT) are both potential environmental pollutants that enter organisms through the food chain affect bodily functions. However, effects mechanisms of MPs TBT exposure (especially co-exposure pollutants) on mammals remain unclear. In this study, Ф5 μm (5MP) was administered alone or in combination with to investigate health risk oral mice. All three treatments induced inflammation liver, altered gut microbiota composition disturbed fecal bile acids...

Recently, both trivalent chromium Cr (III) and hexavalent (VI) have been reported to produce neurotoxicity. However, the underlying mechanisms of neurotoxicity caused by different chemical valence remain unclear. The purpose this study was investigate mechanism induced exposure with states based on metabolic disturbance in zebrafish larvae. Zebrafish embryos were exposed 1 mg/L for 120 hpf respectively. related indexes neural development observed stereoscope behavior analysis system. 8OH-dG...

A visible-light-mediated catalyst- and additive-free method for radical ring-opening fluorosulfonylation of methylenecyclobutanols is reported. Sulfuryl chlorofluoride acts as a FSO

Sulforaphane (SFN) is a promising phytochemical with wide range of antitumor activities. A comprehensive understanding the effects SFN on breast cancer based metabolome and microbiome limited. Thus, we treated MCF-7 cell-transplanted nude mice 50 mg/kg SFN. inhibits cell proliferation. increased levels sulfate-related metabolites glutathione-related decreased tryptophan methyl-purine in urinary metabolic profile. indirectly affected activation aryl hydrocarbon receptor by metabolism. The...

Abstract In recent years, chromium (Cr) has been found to induce neurotoxicity. However, the underlying mechanism remains unclear. This study aimed investigate effects of exposure on metabolome and microbiome that may contribute neurotoxicity in juvenile zebrafish. Zebrafish embryos were exposed 1 mg/L Cr (III) (VI) for 7 days, respectively. Swimming distance locomotor behavior was decreased, acetylcholinesterase activity reduced Cr‐exposed groups. Total cholesterol levels decreased The...

Primary sclerosing cholangitis (PSC) is a chronic cholestatic disease characterized by inflammation and fibrosis of the bile ducts. Cholestasis may lead to hepatic fibrosis, amelioration cholestasis allow recovery from inflammatory fibrotic pathological damage. Prevotella copri (P. copri) interventions have been reported significantly improve liver in 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC)-induced PSC mouse models. Even though P. treatment alone cannot bring about DDC-induced...

Understanding the transport mechanism of peptide Asn-Cys-Trp (NCW) is crucial to improving its intestinal absorption and bioavailability. This study investigated NCW through Caco-2 cell monolayers interaction with DPPC bilayers. Results revealed that after a 3 h incubation, Papp (AP-BL) (BL-AP) values at concentration 5 mmol/L were (22.24 ± 4.52) × 10–7 (6.63 2.31) cm/s, respectively, rates 1.59 0.32 0.62 0.20%, indicating moderate absorption. was found be transported via PepT1 paracellular...

Background and objectives The oral gut microbiota play significant roles in childhood asthma pathogenesis. However, the communication dynamics pathogenic mechanisms by which influence disease development remain incompletely understood. This study investigated potential oral-originated microbiota, specifically Prevotella genus, may contribute to etiology. Methods Oral swab fecal samples from 30 asthmatic children healthy controls were collected. Microbiome composition was characterized using...

In this article, a dual-signal sensor for the fluorescence and colorimetric detection of glyphosate (Gly) is developed based on DNAzyme-mediated click chemistry DNAzyme-regulated CeO2 peroxidase-like activity. DNAzyme can bind to Cu+, triggering reaction between 3-Azido-7-hydroxycoumarin (AHC) 3-ethyn-1-ol (BOL), thus generating strong signal at 475 nm. Due coordination Gly Cu2+, amount reduced Cu+ decreases, resulting in weakening fluorescence. addition, inhibit catalytic site enzyme...

Tributyltin (TBT), an environmental pollutant widely used in antifouling coatings, can cause multiple-organ toxicity and gut microbiome dysbiosis organisms, even changes the host metabolomic profiles. However, little is known about underlying effects links of TBT-induced metabolic dysbiosis. In this study, rats were exposed to TBT at a dose 100 μg kg-1 body weight (BW) for 38 days, followed by multi-omics analysis, including microbiome, metabolomics, metallomics. Results showed that exposure...

In order to investigate the influence of combustion chamber geometry on spray and characteristics in diesel engine, universal CFD software STAR-CD is applied simulate processes three different types chambers engine. The effect in–cylinder air motion, temperature field exhaust emissions are researched this paper. Comparing with experimental results, calculation models proved be validity. results show that differences shape change characteristic flow cylinder, which affects formation mixed gas...

Abstract Background: Epidemiological studies have showed that PAHs may exert its adverse effects on childhood asthma. However, the underlying molecular mechanism remains to be fully elucidated. This study aimed investigate this process in view of metabolic pathway, especially one carbon metabolism and tryptophan metabolism. Methods: Fifty asthmatic children fifty control subjects were recruited study. Serum IgE IL-17A was detected by ELISA assay. concentrations measured GC-MS. One...

Objective To explore the relations of nicotinamide adenine dinucleotide phosphate(NAD[P]H)oxidase p22phox C242T gene polymorphism with hyperlipidemia and cerebral infarction. Methods A case-control association study containing 207 patients(collected from Physical Examination Center March 2014 to 2015), 185 infarction Department Neurology 2015)and 183 controls(collected 2015)was carried out. The genetypes allele frequency were compared; clinical data, lipoprotein oxidation level...

Objective To investigate the effects of hydrochloride fasudil on inflammation and secondary brain injury in rats after intracerebral hemorrhage (ICH). Methods One hundred seventeen male Wistar were randomly divided into normal group (n=9), sham-operated (n=36), ICH (n=36) treatment (ICH/HF, n=36). was caused by injecting non-anticoagulant autologous arterial blood right caudate nucleus, 3 mg HF dissolved 2 mL 0.9% saline solution administrated intraperitioneally once daily (12...