A5008987871- Traditional Chinese Medicine Analysis
- Ginseng Biological Effects and Applications
- Pharmacological Effects of Natural Compounds
- Medicinal Plant Pharmacodynamics Research
- Metabolomics and Mass Spectrometry Studies
- Natural product bioactivities and synthesis
- Chromatography in Natural Products
- Fungal Biology and Applications
- Analytical Chemistry and Chromatography
- Agriculture, Soil, Plant Science
- Antimicrobial Peptides and Activities
- Microbial Natural Products and Biosynthesis
- Alkaloids: synthesis and pharmacology
- Reproductive tract infections research
- Food Quality and Safety Studies
- Biochemical and Structural Characterization
Shandong University
2022-2025
Anhui University of Traditional Chinese Medicine
2023-2025
Artificial intelligence holds great promise for the design of antimicrobial peptides (AMPs); however, current models face limitations in generating AMPs with sufficient novelty and diversity, they are rarely applied to generation antifungal peptides. Here, we develop an alternative pipeline grounded a diffusion model molecular dynamics de novo AMPs. The generated by our have lower similarity identity than those other reported methodologies. Among 40 synthesized experimental validation, 25...
ABSTRACT Danzhi Jiangtang capsule (DJC) is a traditional Chinese medicine prescription that has been clinically used to treat Type 2 diabetes mellitus and its complications. However, research on the chemical compounds present in DJC remains limited. In this study, an analytical strategy based ultra‐performance liquid chromatography quadrupole time‐of‐flight mass spectrometry (UPLC‐Q‐TOF/MS) was developed for rapid systematic characterization of DJC. Firstly, self‐built database established,...
Panax ginseng (P. ginseng), the dried root and rhizome of P. C. A. Meyer, is widely used in many fields as dietary supplements medicine. To characterize chemical constituents cultivated different growth environments, a UPLC-TOF-MS method was established for qualitative analysis. Four hundred eight ginsenosides, including 81 new compounds, were characterized from regions. Among detected 361 ginsenosides recognized region Monsoon Climate Medium Latitudes, possessing largest amount all samples....
To compare the chemical distinctions of Panax ginseng Meyer in different growth environments and explore effects growth-environment factors on P. growth, an ultra-performance liquid chromatography-tandem triple quadrupole time-of-flight mass spectrometry (UPLC-Triple-TOF-MS/MS) was used to characterize ginsenosides obtained by ultrasonic extraction from grown growing environments. Sixty-three were as reference standards for accurate qualitative analysis. Cluster analysis analyze differences...
Compound Shougong Powder (CSP) is a traditional Chinese medicine (TCM) preparation recognized for its efficacy in reducing swelling and relieving pain. It primarily used clinically the treatment of malignant tumors. However, research on chemical compounds present CSP remains limited. In this study, we employed ultra-high-performance liquid chromatography quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF/MS
Abstract Research into traditional Chinese medicine metabolism in feces is one of the key avenues to understanding fate medicines vivo. In this study, we used ultraperformance liquid chromatography–quadrupole time‐of‐flight MS combination with a post‐targeted screening strategy identify prototype components and metabolites rat after oral administration. Based on our group's previous research, component database Qi‐Yu‐San‐Long decoction (QYSLD) was established. Prototype were screened from...
Panax ginseng (P. ginseng), the dried root and rhizome of P. C. A. Meyer, is widely used in many fields as dietary supplements medicine. To characterize chemical constituents cultivated different growth environments, an UPLC-TOF-MS method was established for qualitative analysis. 408 ginsenosides including 81 new compounds were characterized from regions. Among detected compounds, 361 recognized region Monsoon Climate Medium Latitudes, possessing largest amount all samples. Furthermore, 41...
To compare the discrepancy of chemical constituents in Panax ginseng C. A. Meyer cultivated traditional and non-traditional areas, an UPLC-TOF-MS method was established this study to characterize semi-quantitatively analyze composition different P. samples. A metabolomics strategy with multivariate statistical analysis used discriminate divergence P . cultured regions. Totally 408 ginsenosides, including 81 potential new compounds were characterized from Among detected compounds, 361...