A5056987446- RNA modifications and cancer
- RNA Research and Splicing
- CRISPR and Genetic Engineering
- RNA Interference and Gene Delivery
- Mitochondrial Function and Pathology
- Virus-based gene therapy research
- Cancer, Hypoxia, and Metabolism
- RNA and protein synthesis mechanisms
- Genomics and Chromatin Dynamics
- DNA Repair Mechanisms
- Metabolism, Diabetes, and Cancer
- Cancer-related molecular mechanisms research
Baylor College of Medicine
2019-2024
Children's Cancer Center
2021-2024
The University of Texas Southwestern Medical Center
2016
Oncogenic fusion genes as the result of chromosomal rearrangements are important for understanding genome instability in cancer cells and developing useful therapies. To date, mechanisms that create such oncogenic poorly understood. Previously we reported an unappreciated RNA-driven mechanism human prostate which expression chimeric RNA induces specified gene fusions a sequence-dependent manner. One fundamental question yet to be addressed is whether generalizable, or rather, special case...
Abstract The ability to control the expression of a therapeutic gene or transgene in mammalian cells is crucial for safe and efficacious cell therapy, as well elucidating function specific product. Yet current regulation systems either evoke harmful immune responses hosts lack required regulatory efficiency. Here we describe highly responsive RNA-based molecular switch, pA regulator, that harnesses power polyA signal cleavage within 5’ UTR expression. regulator governed by ‘dual mechanism’...
Cancer cells frequently display high rates of aerobic glycolysis (the Warburg effect) in comparison to their nontransformed counterparts. Activated oncogenes and loss tumor suppressors turn alter metabolism induce glycolysis. Here we report that DOC-2/DAB2 interactive protein (DAB2IP), a suppressor gene, decreases the glycolytic activity prostate cancer cell. In addition, DAB2IP inhibits expression hexokinase 2 (HK-II) which catalyzes phosphorylation glucose first step Although molecular...