A5101449660- Catalytic C–H Functionalization Methods
- Asymmetric Synthesis and Catalysis
- Oxidative Organic Chemistry Reactions
- Cyclopropane Reaction Mechanisms
- Covalent Organic Framework Applications
- Synthesis and Characterization of Pyrroles
- Metal-Organic Frameworks: Synthesis and Applications
- Multicomponent Synthesis of Heterocycles
- Catalytic Alkyne Reactions
- Synthesis and biological activity
- Chemical synthesis and alkaloids
- Influenza Virus Research Studies
- Respiratory viral infections research
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Synthesis and Biological Evaluation
- Chemical Synthesis and Reactions
- Membrane Separation and Gas Transport
- Immune Response and Inflammation
- Chemical Synthesis and Analysis
- Analytical Chemistry and Chromatography
- Infection Control and Ventilation
- Synthesis and Reactivity of Heterocycles
- Alkaloids: synthesis and pharmacology
- Cholinesterase and Neurodegenerative Diseases
Guangzhou Medical University
2013-2025
First Affiliated Hospital of Guangzhou Medical University
2013-2025
State Key Laboratory of Respiratory Disease
2013-2025
China Three Gorges University
2023
Xi'an Jiaotong University
2023
Huazhong University of Science and Technology
2015-2022
Hubei Academy of Agricultural Sciences
2020-2022
Ministry of Agriculture and Rural Affairs
2022
Chinese Academy of Sciences
2020-2021
National Clinical Research
2021
Abstract Background Human parainfluenza viruses (HPIVs) are important causes of upper respiratory tract illness (URTI) and lower (LRTI). To analyse epidemiologic clinical characteristics the four types human (HPIVs), patients with acute (ARTI) were studied in Guangzhou, southern China. Methods Throat swabs (n=4755) collected tested from children adults ARTI over a 26-month period, 4447 4755 (93.5%) patients’ presentations recorded for further analysis. Results Of tested, 178 (3.7%) positive...
The proton dissociation degrees and dielectric properties of carriers doped COFs with neutral, polar, Lewis base positively charged sites are investigated to get better understanding structure–conductivity relationship.
Formaldehyde was used as a versatile C1 building block to forge either acyclic or heterocyclic molecules <italic>via</italic> multicomponent reactions with the potential be more sustainable than lengthier alternatives.
Bio-based glycolaldehyde aqueous solution was used as a C2 building block for the synthesis of class dihydrofuran derivatives with aid deep eutectic solvent composed FeCl<sub>3</sub>·6H<sub>2</sub>O and meglumine.
A three-component reaction of indoles, α-bromoacetaldehyde acetals, and ketones was developed by using bismuth(III) triflate as the catalyst to realize a straightforward approach for synthesizing carbazole derivatives. The established mechanistically through autotandem catalysis Bi(OTf)3 in following two steps: (i) Friedel–Crafts-type alkylation indole with acetal, which produced tryptaldehyde-type intermediate (ii) [4 + 2] annulation this ketone component.
The polypyrene polymer with an extended π-conjugated skeleton is attractive for perfluorinated electron specialty gas (F-gas) capture as the high electronegativity of fluorine atoms makes F-gases strongly electronegative gases. Herein, a porous organic framework (termed Ppy-POF) structure and excellent acid resistance was constructed. Systematic studies have shown that abundant structures gradient electric field distribution in Ppy-POF can endow it exceptional adsorption selectivity...
Separation of aromatic/alkane mixtures similar size and properties is critical for the chemical industry as conventional thermal separation a high-cost an energy-intensive process. Adsorptive based on porous materials prospective economical technology well suitable alternative to energy-inefficient heat-driven With this in mind, we design synthesize novel microporous polymer (termed CMP-S-1) with conjugated aromatic skeleton adsorbent separation. CMP-S-1 possesses high adsorption selectivity...
Synthesis of solid-state proton-conducting membranes with low activation energy and high proton conductivity under anhydrous conditions is a great challenge. Here, we show simple convenient way to prepare covalent triazine framework (CTF-Mx) acid in situ doping for conduction wide temperature range from subzero elevated (160 °C). The dissociation continuous hydrogen bond network CTF-Mx make the membrane achieve 1.21×10-3 S cm-1 (−40 °C) 2.08×10-2 conditions. Molecular dynamics relaxation...
Abstract 2‐Alkoxy‐2,3‐dihydrofurans were found to be versatile benzannulation reagents. Indoles can synthesized in good excellent yields via the [4+2] annulation of 2‐butoxy‐2,3‐dihydrofuran with pyrroles catalyzed by copper bromide. With same protocol, carbazoles also obtained when indoles are used as starting material aid p ‐toluenesulfonic acid. This type reagent synthesize benzofuran, benzothiophene and naphthalene derivatives presence a catalytic amount triflic acid moderate yields....
2,3-Disubstituted benzofurans were synthesized from acrolein dimer and 1,3-dicarbonyl compounds by using N-bromosuccinimide as an oxidizing agent. The method was used to synthesize two commercial drug molecules, benzbromarone amiodarone. proposed mechanism of the reaction involves a (NBS)-assisted autotandem catalysis with Lewis acid catalyst. To proof mechanism, intermediate isolated successfully, which can be converted 4,5,6,7-tetrahydrobenzofurans.
The exploration of natural products as lead scaffolds continues to serve a valuable strategy for the development novel antifungal agents. In this investigation, we focused on furanoid compound 2-heptyl-5-hexylfuran-3-carboxylic acid (HHCA) and designed synthesized four distinct series multisubstituted furan carboxylic derivatives. Comprehensive structural characterization biological evaluation were performed all 48 compounds. vitro screening against eight prevalent plant pathogens revealed...
Background Jing-Yin-Gu-Biao formula (JYGBF) is a Chinese medicine derived from Yupingfeng power, Huoxiangzhengqi powder and Yinqiao powder, has been widely used to treat acute respiratory infections. This study aims observe the effects of JYGBF against postinfluenza Staphylococcus aureus ( S. ) infection. Purpose design A mouse model secondary infection following PR8 was established evaluate protective related mechanisms were validated in vivo vitro . Results The administration significantly...
Abstract A simple aluminium(III) chloride‐catalyzed synthesis of tri‐substituted furans from aliphatic aldehydes and 1,3‐dicarbonyl compounds was developed by using N ‐bromosuccinimide (NBS) as an oxidant. This method effective for the various furan derivatives. Some products were not accessible with previously reported methods. Mechanically, this reaction involved auto‐tandem catalysis based on a newly acid‐acid‐catalyzed tandem to ensure that successfully synthesized. magnified image
Abstract Benzo[α]carbazoles were synthesized from 2‐phenylindoles and α‐bromoacetaldehyde using bismuth trichloride as a catalyst. The reaction was triggered by trichloride‐catalyzed Friedel‐Crafts alkylation of these two precursors, which provided tryptaldehyde intermediate that underwent intramolecular olefination to form the final product. Interestingly, HBr byproduct generated in upstream step catalyzed following downstream steps, thus creating byproduct‐participated relay catalytic...
Abstract An effective method to synthesize α‐functionalized furan and pyrrole derivatives was developed using 2‐alkoxy‐2,3‐dihydrofurans as modular precursors. This protocol featured a previously unreported tandem nucleophilic substitution/heteroaromatization reaction. Nucleophiles such indole, α‐oxoketene dithioacetal, trimethoxybenzene, dimethoxynaphthalene can react readily with afford five‐membered ring heterocycles in the presence of acid catalysts, copper bromide iron chloride. The...