A5110585323- Bone Tissue Engineering Materials
- Dental Implant Techniques and Outcomes
- Dental materials and restorations
- Extracellular vesicles in disease
- Wound Healing and Treatments
- Nanoplatforms for cancer theranostics
- Power Systems and Renewable Energy
- Osteoarthritis Treatment and Mechanisms
- Orthopaedic implants and arthroplasty
- Electrospun Nanofibers in Biomedical Applications
- Laser-Ablation Synthesis of Nanoparticles
- Titanium Alloys Microstructure and Properties
- Metal and Thin Film Mechanics
- 3D Printing in Biomedical Research
- Facial Trauma and Fracture Management
- Bone Tumor Diagnosis and Treatments
- Tribology and Lubrication Engineering
- Sarcoma Diagnosis and Treatment
- Microgrid Control and Optimization
- Hedgehog Signaling Pathway Studies
- Musculoskeletal synovial abnormalities and treatments
- Bone Metabolism and Diseases
- Brain Tumor Detection and Classification
- Tissue Engineering and Regenerative Medicine
- Lubricants and Their Additives
Henan Agricultural University
2025
China National Administration of Coal Geology
2025
Zhongyuan University of Technology
2025
Civil Aviation Flight University of China
2024
North China University of Science and Technology
2024
Hohai University
2024
Ministry of Natural Resources
2024
Shanghai Sixth People's Hospital
2013-2023
Shanghai Jiao Tong University
2014-2023
Nanjing University
2022
Real-time monitoring of vessel dysfunction is great significance in preclinical research. Optical bioimaging the second near-infrared (NIR-II) window provides advantages including high resolution and fast feedback. However, reported molecular dyes are hampered by limited blood circulation time (~ 5-60 min) short absorption emission wavelength, which impede accurate long-term monitoring. Here, we report a NIR-II molecule (LZ-1105) with beyond 1000 nm. Thanks to long (half-life 3.2 h),...
The 3D-printed Fe<sub>3</sub>O<sub>4</sub>/MBG/PCL scaffolds with potential multifunctionality would be promising for use in the treatment and regeneration of large bone defects after tumor resection.
Articular cartilage has limited self-regenerative capacity and the therapeutic methods for defects are still dissatisfactory in clinic. Recent studies showed that exosomes derived from mesenchymal stem cells promoted chondrogenesis by delivering bioactive substances to recipient cells, indicating might be a novel method repairing defect. Herein, we investigated role mechanism of human umbilical cord small extracellular vesicles (hUC-MSCs-sEVs) on regeneration. In vitro results hUC-MSCs-sEVs...
Excessive scar formation has adverse physiological and psychological effects on patients; therefore, a therapeutic strategy for rapid wound healing reduced is urgently needed. Herein, bilayered thiolated alginate/PEG diacrylate (BSSPD) hydrogels were fabricated sequential release of small extracellular vesicles (sEVs), which acted in different phases, to achieve scarless healing. The sEVs secreted by bone marrow derived mesenchymal stem cells (B-sEVs) released from the lower layer promote...
Biocompatible synthetic scaffolds with enhanced osteogenic and angiogenic capacity are of great interest for the repair large (critical size) bone defects. In this study, we investigated an approach based on controlled delivery copper (Cu) ions from borate bioactive glass stimulating angiogenesis osteogenesis in a rodent calvarial defect model. Borate (pore size = 200-400 μm) doped varying amounts Cu (0-3.0 wt% CuO) were created using polymer foam replication technique. When immersed...
In the clinic, bone defects resulting from infections, trauma, surgical resection and genetic malformations remain a significant challenge. field of tissue engineering, three-dimensional (3D) scaffolds are promising for treatment defects. this study, calcium sulfate hydrate (CSH)/mesoporous bioactive glass (MBG) were successfully fabricated using 3D printing technique, which had regular uniform square macroporous structure, high porosity excellent apatite mineralization ability. Human...
Doxorubicin hydrochloride (DOX)- and indocyanine green (ICG)-loaded microneedle (MN) patches (PVP@DOX/MSN@ICG) were successfully fabricated using a two-step casting process, which is promising strategy for synergistic therapy of superficial tumors.
Development of bioactive scaffolds with controllable architecture and high osteogenic capability for bone tissue engineering is hotly pursued. In this study, three-dimensional (3D) mesoporous glass (MBG) poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) composite well-defined pore structures compressive strength (∼5-12 MPa) were synthesized by a 3D printing technique. Compared to reported polymer-bonded MBG scaffolds, the incorporation biocompatible PHBHHx polymer as particle binder...
Rapid and effective osseointegration, as a critical factor in affecting the success rate of titanium (Ti) implants orthopedic applications, is significantly affected by their surface microstructure chemical composition. In this work, microgrooved Ti-6Al-4V alloys with graphene oxide coating (Ti-G-GO) were fabricated combination laser processing assembly techniques. The osteogenic capability vitro new bone formation vivo systematically investigated, biomechanical pull-out tests screws also...
Rationale: Chronic wounds associated with diabetes exact a heavy burden on individuals and society do not have specific treatment. Exosome therapy is an extension of stem cell therapy, RNA interference (RNAi)-based type advanced precision therapy. Based the discovery chronic wound-related genes in diabetes, we combined exosome RNAi through engineering approach for treatment diabetic wounds. Methods: We to establish diabetes-associated via engineered approach. Results: First, express low...
In situ monitoring of tissue regeneration progression is primary importance to basic medical research and clinical transformation. Despite significant progress in the field engineering regenerative medicine, few technologies have been established inspect process. Here, we present an integrated second near-infrared (NIR-II, 1000-1700 nm) window vivo imaging strategy based on 3D-printed bioactive glass scaffolds doped with NIR-II ratiometric lanthanide-dye hybrid nanoprobes, allowing for early...
Angiogenesis–osteogenesis coupling processes are vital in bone tissue engineering.
Evaluation of zinc-doped mesoporous hydroxyapatite microspheres for the construction a novel biomimetic scaffold optimized bone augmentation Weilin Yu,1,* Tuan-Wei Sun,2,3,* Chao Qi,2,3 Zhenyu Ding,1 Huakun Zhao,1 Shichang Zhongmin Shi,1 Ying-Jie Zhu,2,3 Daoyun Chen,1 Yaohua He1,4 1Department Orthopedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 2State Key Laboratory High Performance Ceramics and Superfine Microstructure, Institute Ceramics, Chinese Academy Sciences,...
The development of a new generation injectable bone cements that are bioactive and have enhanced osteogenic capacity for rapid osseointegration is receiving considerable interest. In this study, novel cement (designated Sr-BBG) composed strontium-doped borate glass particles chitosan-based bonding phase was prepared evaluated in vitro vivo. provided the benefits bioactivity, conversion to hydroxyapatite, ability stimulate osteogenesis, while chitosan cohesive biocompatible biodegradable...
Tricalcium silicate/mesoporous bioactive glass (C3S/MBG) cement scaffolds were successfully fabricated for the first time by 3D printing with a curing process, which combined hydraulicity of C3S excellent biological property MBG together.