Caroline Gluck
A5048501594- Chronic Kidney Disease and Diabetes
- Renal Diseases and Glomerulopathies
- Epigenetics and DNA Methylation
- Blood Pressure and Hypertension Studies
- COVID-19 Clinical Research Studies
- COVID-19 Impact on Reproduction
- Diabetes and associated disorders
- Dialysis and Renal Disease Management
- Genetic Syndromes and Imprinting
- Renal and related cancers
- Renal function and acid-base balance
- Porphyrin Metabolism and Disorders
- Hemodynamic Monitoring and Therapy
- Heart Failure Treatment and Management
- Pregnancy and Medication Impact
- Pediatric Urology and Nephrology Studies
- Renal cell carcinoma treatment
- Complement system in diseases
- Birth, Development, and Health
- Vasculitis and related conditions
- Kidney Stones and Urolithiasis Treatments
- Pancreatitis Pathology and Treatment
- Climate Change and Health Impacts
- Genomics and Rare Diseases
- Biomedical Research and Pathophysiology
Nemours Children's Health System
2020-2025
DuPont (United States)
2020-2023
Alfred I. duPont Hospital for Children
2019-2023
Dupont Hospital
2020-2021
University of Pennsylvania
2017-2020
Children's Hospital of Philadelphia
2017
University College London
2012
Chronic kidney disease (CKD) is defined by reduced estimated glomerular filtration rate (eGFR). Previous genetic studies have implicated regulatory mechanisms contributing to CKD. Here we present epigenome-wide association of eGFR and CKD using whole-blood DNA methylation 2264 ARIC Study 2595 Framingham Heart participants identify epigenetic signatures function. Of 19 CpG sites significantly associated (P < 1e-07) with eGFR/CKD replicated, five also associate renal fibrosis in biopsies from...
Mutations of the gene for glucocerebrosidase 1 (GBA) cause Gaucher disease (GD), an autosomal recessive lysosomal storage disorder. Individuals with homozygous or heterozygous (carrier) mutations GBA have a significantly increased risk development Parkinson's (PD), clinical and pathological features that mirror sporadic disease. The mechanisms whereby induce dopaminergic cell death Lewy body formation are unknown. There is evidence mitochondrial dysfunction oxidative stress in PD so we...
Abstract Epigenetic changes might provide the biological explanation for long-lasting impact of metabolic alterations diabetic kidney disease development. Here we examined cytosine methylation human tubules using Illumina Infinium 450 K arrays from 91 subjects with and without diabetes varying degrees a cross-sectional design. We identify associated structural damage build model function decline. find that levels 65 probes are degree fibrosis at genome wide significance. In total 471 improve...
In patients with diabetes mellitus, poor metabolic control has a long-lasting impact on kidney disease development. Epigenetic changes, including cytosine methylation, have been proposed as potential mediators of the effect adverse events. Our understanding presence and contribution methylation changes to development is limited because lack comprehensive base-resolution methylome information human tissue samples site-specific editing. Base resolution, whole-genome bisulfite sequencing maps...
Poor metabolic control and host genetic predisposition are critical for diabetic kidney disease (DKD) development. The epigenome integrates information from sequence variations alterations. Here, we performed a genome-wide methylome association analysis in 500 subjects with DKD the Chronic Renal Insufficiency Cohort phenotypes, including glycemic control, albuminuria, function, function decline. We show distinct methylation patterns associated each phenotype. define that underlying...
There are limited data on the impact of COVID-19 in children with a kidney transplant (KT). We conducted prospective cohort study through Improving Renal Outcomes Collaborative (IROC) to collect clinical outcome about pediatric KT patients. Twenty-two IROC centers that care for 2732 patients submitted testing and outcomes 281 tested SARS-CoV-2 by PCR. Testing indications included symptoms and/or potential exposures (N = 134, 47.7%) per hospital policy 154, 54.8%). Overall, 24 (8.5%)...
Performing adequately powered clinical trials in pediatric diseases, such as SLE, is challenging. Improved recruitment strategies are needed for identifying patients.Electronic health record algorithms were developed and tested to identify children with SLE both without lupus nephritis. We used single-center electronic data develop computable phenotypes composed of diagnosis, medication, procedure, utilization codes. These evaluated iteratively against a manually assembled database patients...
Importance It remains unclear whether children and adolescents with SARS-CoV-2 infection are at heightened risk for long-term kidney complications. Objective To investigate is associated an increased of postacute outcomes among pediatric patients, including those preexisting disease or acute injury (AKI). Design, Setting, Participants This retrospective cohort study used data from 19 health institutions in the National Institutes Health Researching COVID to Enhance Recovery (RECOVER)...
Objectives To assess the potential of a multi-institutional pediatric learning health system for comparative effectiveness research in pediatric-onset systemic lupus erythematosus (SLE), we characterized renin angiotensin aldosterone (RAAS) inhibitor utilization and feasibility ascertaining key treatment indications outcomes, including hypertension proteinuria. Methods We identified children with SLE nephritis (LN) at 6 PEDSnet institutions using previously developed computable phenotypes. A...
IgA vasculitis is the most common in children and often complicated by acute nephritis (IgAVN). Risk of chronic kidney disease (CKD) among with IgAVN remains unknown. This study aimed to describe clinical management outcomes a large cohort IgAVN.
Abstract Many barriers to genetic testing currently exist which delay or prevent diagnosis. These include wait times, staffing, education, and cost. Specialists are able identify patients with disease that may need testing, but lack the genetics support facilitate in most cost, time, medically effective manner. The Nephrology Division Genetic Testing Stewardship Program at Nemours A.I. duPont Hospital for Children created a novel service delivery model nephrologists counselors collaborate...
Background The objectives of this study were to use electronic health record data from a US national multicenter pediatric network identify large cohort children with CKD, evaluate CKD progression, and examine clinical risk factors for kidney function decline. Methods This retrospective identified seen between January 1, 2009, February 28, 2022. Data six systems in PEDSnet. We aged 18 months years who met criteria CKD: two eGFR values <90 ≥15 ml/min per 1.73 m 2 separated by ≥90 days...
Children with glomerular disease have unique risk factors for compromised bone health. Studies addressing skeletal complications in this population are lacking.This retrospective cohort study utilized data from PEDSnet, a national network of pediatric health systems standardized electronic record more than 6.5 million patients 2009 to 2021. Incidence rates (per 10,000 person-years) fracture, slipped capital femoral epiphysis (SCFE), and avascular necrosis/osteonecrosis (AVN) 4598 children...
BackgroundIdentification of abnormal blood pressure (BP) in children requires normative data. We sought to examine the feasibility using "real-world" office BP data obtained from electronic health records (EHR) generate age-, sex- and height-specific percentiles for children.MethodsUsing collected 01/01/2009–8/31/2021 eight large children's healthcare organisations PEDSnet, we applied a mixed-effects polynomial regression model with random slopes Z-scores compared them currently used...
We investigated the risks of post-acute and chronic adverse kidney outcomes SARS-CoV-2 infection in pediatric population via a retrospective cohort study using data from RECOVER program. included 1,864,637 children adolescents under 21 19 children's hospitals health institutions US with at least six months follow-up time between March 2020 May 2023. divided patients into three strata: pre-existing disease (CKD), acute injury (AKI) during phase (within 28 days) infection, without CKD or AKI....
Nephrectomy, the standard of care for localized renal cell carcinoma (RCC), may lead to kidney function loss. Our goal was identify prognostic biomarkers postoperative using metabolomics. Metabolomics data from benign parenchyma were collected prospectively 138 patients with RCC who underwent nephrectomy at a single institution. The primary endpoint difference between and preoperative estimated glomerular filtration (eGFR) rate divided by elapsed time (eGFR slope). eGFR slope calculated ∼2...
Background: COVID-19 has been associated with increased morbidity in kidney transplant recipients We aimed to identify risk factors for mortality hospitalized Methods: retrospectively reviewed the medical records of 75 admitted at our institution Results: Among patients, 28 (37%) died a median 8 days (range, 1-36) after admission hospital The Table summarizes demographics and initial labs values both groups Most patients were Hispanic (54%) African American (32%) 97% had hypertension 65%...