A5026588307- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Dialysis and Renal Disease Management
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Acute Kidney Injury Research
- Renal Transplantation Outcomes and Treatments
- Birth, Development, and Health
- Nitric Oxide and Endothelin Effects
- Renin-Angiotensin System Studies
- Mast cells and histamine
- Biomedical Research and Pathophysiology
- Eicosanoids and Hypertension Pharmacology
- Organ Donation and Transplantation
- Autoimmune Bullous Skin Diseases
- Diabetes Treatment and Management
- Systemic Lupus Erythematosus Research
- Pregnancy and Medication Impact
- Complement system in diseases
- Liver Disease Diagnosis and Treatment
- Blood Pressure and Hypertension Studies
- TGF-β signaling in diseases
- Organ Transplantation Techniques and Outcomes
- Hormonal and reproductive studies
- Chronic Lymphocytic Leukemia Research
- Receptor Mechanisms and Signaling
University of Kansas Medical Center
1994-2022
Kansas City VA Medical Center
2010-2022
Biomedical Research Foundation
2020-2022
Veterans Health Administration
1992-2020
University Medical Center
2019
University of Washington
2015
United States Department of Veterans Affairs
1986-2012
Medical College of Wisconsin
2001-2010
Milwaukee VA Medical Center
2010
Rockford University
2008
Heavy proteinuria and progressive renal injury recur after transplantation in up to 40 percent of patients with failure caused by idiopathic focal segmental glomerulosclerosis. A circulating factor may be responsible for this recurrence.
AimsThere is a significant uncertainty regarding the effect of testosterone replacement therapy (TRT) on cardiovascular (CV) outcomes including myocardial infarction (MI) and stroke. The aim this study was to examine relationship between normalization total (TT) after TRT CV events as well all-cause mortality in patients without previous history MI
Tumor necrosis factor-alpha (TNF-alpha) is a cytokine that plays central role in inflammation. Glomerular levels of TNF-alpha are elevated human and experimental glomerulonephritis. cells produce respond to TNF-alpha. One the mechanisms by which these through generation reactive oxygen species. In this study, effect on albumin permeability (P(albumin)) isolated rat glomeruli possible mechanism were examined. Isolated incubated with (0.4 ng/ml), anti-TNF-alpha antibodies, species scavengers...
Recurrent focal segmental glomerulosclerosis (FSGS) following transplantation is ascribed to the presence of a circulating FSGS permeability factor (FSPF). Plasmapheresis (PP) can induce remission proteinuria in recurrent FSGS. This study addressed efficacy pre‐transplant PP decreasing incidence recurrence high‐risk patients. Ten patients at for because rapid progression renal failure (n = 4) or prior transplant 6) underwent course 8 treatments peri‐operative period. Recurrences were...
Abstract. A circulating causative factor has been postulated in focal segmental glomerulosclerosis (FSGS). It shown that serum or plasma from some FSGS increases glomerular albumin permeability (P alb ) vitro. P greater than 0.5 (i.e., FS activity) is associated with recurrence after transplantation. Specimens 15 patients were studied to document the presence of a factor, isolate this characterize its biochemical properties, and show effect vivo. Total lipids extracted by chloroform/methanol...
Macromolecular permeability of the glomerular capillary has been inferred from clearance endogenous protein or infused macromolecules. Permeability is increased after treatment with polycations as well renal injury. It previously shown that capillaries glomeruli isolated normal mammals expand collapse in response to transcapillary albumin gradients and magnitude changes volume total are directly proportional applied oncotic gradients. In experiments presented here, responses control treated...
Endothelin (ET) 1 is a potent vasoactive peptide implicated in the pathogenesis of hypertension and renal disease. The aim current study was to test hypotheses that ET-1 increases albumin permeability glomeruli isolated from normal rats chronic infusion will increase glomerular inflammation independent blood pressure. Glomerular determined change volume induced by exposing oncotic gradients. Incubation taken with at concentration did not produce direct contraction (1 nmol/L) significantly...
CLCF-1 is a cytokine known for B-cell stimulation and neurotrophic properties. We have identified as potential injurious factor in the human renal disease focal segmental glomerulosclerosis (FSGS). investigated its effects on cells function vitro vivo studies. Methods include measurement of effect phosphorylation target molecules JAK/STAT pathway, cytoskeleton cell morphology cultured podocytes, albumin permeability isolated rat glomeruli, tissue urine after acute or chronic injection. In...
Patients with resistant focal segmental glomerulosclerosis (FSGS) who are unresponsive to corticosteroids and other immunosuppressive agents at very high risk of progression end stage kidney disease. In the absence curative treatment, current therapy centers on renoprotective interventions that reduce proteinuria fibrosis. The FONT (Novel Therapies for Resistant FSGS) Phase II clinical trial (NCT00814255, Registration date December 22, 2008) was designed assess efficacy adalimumab galactose...
Angiotensin II (ANG II), atrial natriuretic peptide III (ANP), and sodium nitroprusside (SNP) alter capillary hydraulic conductivity in isolated glomeruli. These agents also affect cyclic nucleotide levels of glomerular epithelial cells (GEC). ANG increases cAMP, whereas ANP SNP increase cGMP. The effects these vasoactive substances on GEC cytoskeleton were tested by incubating from primary cultures or an established cell line with each agent. Changes the assessed staining for F-actin Bodipy...
Angiotensin II decreases glomerular filtration rate, renal plasma flow, and capillary hydraulic conductivity. Although angiotensin receptors have been demonstrated in mesangial cells proximal tubule cells, the presence of epithelial has not previously shown. Previously, we reported that caused an accumulation cAMP a reorganization actin cytoskeleton cultured cells. Current studies were conducted to verify by immunological non-peptide receptor ligand binding techniques ascertain activation...