Marcus Lacerda
A5001446475- Malaria Research and Control
- Mosquito-borne diseases and control
- Hemoglobinopathies and Related Disorders
- Venomous Animal Envenomation and Studies
- COVID-19 Clinical Research Studies
- Neonatal Health and Biochemistry
- Vector-borne infectious diseases
- Rabies epidemiology and control
- Long-Term Effects of COVID-19
- Viral Infections and Vectors
- SARS-CoV-2 and COVID-19 Research
- Complement system in diseases
- Parasites and Host Interactions
- HIV/AIDS Research and Interventions
- Invertebrate Immune Response Mechanisms
- Methemoglobinemia and Tumor Lysis Syndrome
- Drug-Induced Hepatotoxicity and Protection
- Trypanosoma species research and implications
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV-related health complications and treatments
- Insect symbiosis and bacterial influences
- Hepatitis B Virus Studies
- Infectious Encephalopathies and Encephalitis
- Fungal Infections and Studies
- Marine Invertebrate Physiology and Ecology
Fundação de Medicina Tropical
2016-2025
Fundação Oswaldo Cruz
2016-2025
Universidade Federal do Amazonas
2014-2025
Universidade do Estado do Amazonas
2016-2025
The University of Texas Medical Branch at Galveston
2023-2025
Leoni (Germany)
2019-2025
Amazon (United States)
2011-2024
Ministério da Saúde
2023-2024
Instituto de Saúde
2024
Universidade Federal de Minas Gerais
2024
<h3>Importance</h3> There is no specific antiviral therapy recommended for coronavirus disease 2019 (COVID-19). In vitro studies indicate that the effect of chloroquine diphosphate (CQ) requires a high concentration drug. <h3>Objective</h3> To evaluate safety and efficacy 2 CQ dosages in patients with severe COVID-19. <h3>Design, Setting, Participants</h3> This parallel, double-masked, randomized, phase IIb clinical trial 81 adult who were hospitalized acute respiratory syndrome (SARS-CoV-2)...
Malaria is still a major public health problem in Brazil, with approximately 306,000 registered cases 2009, but it estimated that the early 1940s, around six million of malaria occurred each year. As result fight against disease, number decreased over years and smallest numbers to-date were recorded 1960s. From mid-1960s onwards, Brazil underwent rapid disorganized settlement process Amazon this migratory movement led to progressive increase reported cases. Although main mosquito vector...
Recent gains in reducing the global burden of malaria are threatened by emergence Plasmodium falciparum resistance to artemisinins. The discovery that mutations portions a P. gene encoding kelch (K13)–propeller domains major determinant has provided opportunities for monitoring such on scale.
Steroid use for coronavirus disease 2019 (COVID-19) is based on the possible role of these drugs in mitigating inflammatory response, mainly lungs, triggered by severe acute respiratory syndrome 2 (SARS-CoV-2). This study aimed to evaluate efficacy methylprednisolone (MP) among hospitalized patients with suspected COVID-19.A parallel, double-blind, placebo-controlled, randomized, Phase IIb clinical trial was performed aged ≥18 years clinical, epidemiological, and/or radiological COVID-19 at...
Background.Plasmodium falciparum and Plasmodium vivax are responsible for most of the global burden malaria. Although accentuated pathogenicity P. occurs because sequestration mature erythrocytic forms in microvasculature, this phenomenon has not yet been noted vivax. The increasing number severe manifestations infections, similar to those observed malaria, suggests that key pathogenic mechanisms (eg, cytoadherence) might be shared by 2 parasites. Methods. Mature vivax–infected erythrocytes...
Infections with protozoan parasites are a major cause of disease and mortality in many tropical countries the world. Diseases caused by species genera Trypanosoma (Human African Trypanosomiasis Chagas Disease) Leishmania (various forms Leishmaniasis) among seventeen "Neglected Tropical Diseases" (NTDs) defined as such WHO due to neglect financial investment into research development new drugs large part pharmaceutical industry public awareness high income countries. Another is malaria...
Treatment of Plasmodium vivax malaria requires the clearing asexual parasites, but relapse can be prevented only if dormant hypnozoites are cleared from liver (a treatment termed "radical cure"). Tafenoquine is a single-dose 8-aminoquinoline that has recently been registered for radical cure P. vivax.
The outbreak of new coronavirus disease 2019 (COVID-19) reported for the first time in Wuhan, China late December have rapidly spread to other countries and it was declared on January 30, 2020 as a public health emergency international concern (PHEIC) by World Health Organization. Before COVID-19 cases were Brazil, several measures been implemented including adjustment legal framework carry out isolation quarantine. As increased significantly, measures, mainly reduce mortality severe cases,...
Tafenoquine, a single-dose therapy for Plasmodium vivax malaria, has been associated with relapse prevention through the clearance of P. parasitemia and hypnozoites, termed "radical cure."
The bacille Calmette-Guérin (BCG) vaccine has immunomodulatory "off-target" effects that have been hypothesized to protect against coronavirus disease 2019 (Covid-19).
BackgroundButantan–Dengue Vaccine (Butantan-DV) is an investigational, single-dose, live, attenuated, tetravalent vaccine against dengue disease, but data on its overall efficacy are needed.MethodsIn ongoing phase 3, double-blind trial in Brazil, we randomly assigned participants to receive Butantan-DV or placebo, with stratification according age (2 6 years, 7 17 and 18 59 years); 5 years of follow-up planned. The objectives the were evaluate symptomatic, virologically confirmed any...
BackgroundTwice-yearly subcutaneous lenacapavir has been shown to be efficacious for prevention of HIV infection in cisgender women. The efficacy preexposure prophylaxis (PrEP) men, transgender women, and gender-nonbinary persons is unclear.MethodsIn this phase 3, double-blind, randomized, active-controlled trial, we randomly assigned participants a 2:1 ratio receive every 26 weeks or daily oral emtricitabine–tenofovir disoproxil fumarate (F/TDF). primary analysis compared the incidence...
The effectiveness of BCG vaccine for adult pulmonary tuberculosis remains uncertain. In this study, we aimed to evaluate the effect vaccination with BCG-Denmark prevent initial and sustained interferon-γ release assay conversion in Brazilian health-care workers.
To achieve malaria elimination, Brazil must implement Plasmodium vivax radical cure. We aimed to investigate the operational feasibility of point-of-care, quantitative, glucose-6-phosphate dehydrogenase (G6PD) testing followed by chloroquine plus tafenoquine or primaquine.
We describe a case series of 17 patients hospitalized in Manaus (western Brazilian Amazon) with PCR-confirmed Plasmodium vivax infection who were treated chloroquine and primaquine. The major complications jaundice severe anemia. No vivo resistance was detected. These data help characterize the clinical profile P. malaria Latin America.
Background. Severe disease attributable to Plasmodium vivax infection is already well described worldwide; however, autopsies in these patients are scarce. Methods. From 1996 2010, 19 patient deaths with a clinical diagnosis of P. occurred tertiary care center the Brazilian Amazon. Seventeen were fully autopsied. Clinical charts, macroscopic autopsy reports, and stored paraffinized tissue blocks retrieved. Nested polymerase chain reaction was performed samples spleen lung confirm...
Infections with protozoan parasites are a major cause of disease and mortality in many tropical countries the world. Diseases caused by species genera Trypanosoma (Human African Trypanosomiasis Chagas Disease) Leishmania (various forms Leishmaniasis) among seventeen "Neglected Tropical Diseases" (NTDs) defined WHO. Furthermore, malaria (caused various Plasmodium species) can be considered neglected certain regard to availability affordability antimalarials. Living organisms, especially...