A5008962181- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- T-cell and Retrovirus Studies
- HIV-related health complications and treatments
- Mosquito-borne diseases and control
- Animal Disease Management and Epidemiology
- Vector-Borne Animal Diseases
- Viral Infections and Vectors
- Pneumocystis jirovecii pneumonia detection and treatment
- Immune Cell Function and Interaction
- Viral-associated cancers and disorders
- SARS-CoV-2 and COVID-19 Research
- Syphilis Diagnosis and Treatment
- Malaria Research and Control
- Virology and Viral Diseases
- Cytomegalovirus and herpesvirus research
- Science and Education Research
- Hepatitis B Virus Studies
- Reproductive tract infections research
- HIV/AIDS oral health manifestations
- Tuberculosis Research and Epidemiology
- COVID-19 Clinical Research Studies
- T-cell and B-cell Immunology
- Lymphoma Diagnosis and Treatment
Universidade Federal da Bahia
2016-2025
Complexo Hospitalar Universitário Professor Edgard Santos
2016-2025
Fundação Bahiana de Infectologia
2002-2025
Instituto de Saúde
2025
Hospital Ana Nery
2000-2024
Emory University
2024
Johns Hopkins University
2024
Grady Memorial Hospital
2024
Escola Bahiana de Medicina e Saúde Pública
2022
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2019
Abstract EBV-encoded microRNAs (miRNAs) have been identified and their functions are being studied. The expression pattern of these miRNAs in clinical samples EBV-associated non–Hodgkin's lymphomas is unknown. We analyzed five primary “endemic” pediatric Burkitt's (BL), two acquired immunodeficiency syndrome (AIDS)-related type I latency BL lines, a III line, three EBV+ effusion (PEL), AIDS-related diffuse large B-cell (DLBCL) for miRNAs. A markedly elevated miRNA BHRF1-3 relative to its...
Nosocomial bloodstream infections (nBSIs) are an important cause of morbidity and mortality. Data from a nationwide, concurrent surveillance study, Brazilian SCOPE (Surveillance Control Pathogens Epidemiological Importance), were used to examine the epidemiology microbiology nBSIs at 16 hospitals. In our study 2,563 patients with included 12 June 2007 31 March 2010. Ninety-five percent BSIs monomicrobial. Gram-negative organisms caused 58.5% these BSIs, Gram-positive 35.4%, fungi 6.1%. The...
During 2015 to 2016, Brazil reported more Zika virus (ZIKV) cases than any other country, yet population exposure remains unknown. Serological studies of ZIKV are hampered by cross-reactive immune responses against heterologous viruses. We conducted serosurveys for ZIKV, dengue (DENV), and Chikungunya (CHIKV) in 633 individuals prospectively sampled during including microcephaly non-microcephaly pregnancies, HIV-infected patients, tuberculosis university staff Salvador northeastern using...
In TANGO, switching to dolutegravir/lamivudine (DTG/3TC) demonstrated long-term noninferior efficacy vs continuing tenofovir alafenamide-based regimens in treatment-experienced adults with HIV-1. The phase 3 SALSA study evaluated and safety of DTG/3TC compared various 3-/4-drug current antiretroviral (CARs).Adults HIV-1 RNA <50 copies/mL no previous virologic failure were randomized (1:1, stratified by baseline third agent class) switch once-daily fixed-dose combination or continue CAR...
BackgroundTwice-yearly subcutaneous lenacapavir has been shown to be efficacious for prevention of HIV infection in cisgender women. The efficacy preexposure prophylaxis (PrEP) men, transgender women, and gender-nonbinary persons is unclear.MethodsIn this phase 3, double-blind, randomized, active-controlled trial, we randomly assigned participants a 2:1 ratio receive every 26 weeks or daily oral emtricitabine–tenofovir disoproxil fumarate (F/TDF). primary analysis compared the incidence...
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the cause of Disease 2019 (COVID-19). Although Real Time Reverse Transcription Polymerase Chain Reaction (qRT-PCR) respiratory specimens gold standard test for detection SARS-CoV-2 infection, collecting nasopharyngeal swabs causes discomfort to patients and may represent considerable risk healthcare workers. The use saliva as a diagnostic sample has several advantages.The aim this study was validate biological diagnosis...
The explosive spread of Zika virus (ZIKV) and associated microcephaly present an urgent need for sensitive specific serodiagnostic tests, particularly pregnant women in dengue (DENV)-endemic regions. Recent reports enhanced ZIKV replication by dengue-immune sera have raised concerns about the role previous DENV infection on risk severity other complications.
The introduction of highly active antiretroviral therapy marked a major gain in efficacy HIV/AIDS treatment and reduction morbidity mortality the infected patients. However, high levels adherence are required to obtain virologic suppression. In Brazil, policy free universal access has been place since 1996, although there reports poor adherence.
Abstract The Zika virus outbreak in Latin America resulted congenital malformations, called syndrome (CZS). For unknown reasons, CZS incidence was highest northeastern Brazil; one potential explanation is that dengue (DENV)–mediated immune enhancement may promote development. In contrast, our analyses of historical DENV genomic data refuted the hypothesis unique genome signatures for Brazil explain uneven dispersion cases. To confirm findings, we performed serotype-specific neutralization...
Severe scabies has been associated with HTLV infection. To evaluate the impact of HTLV-I/HIV-1 co-infection on clinical presentation scabies, we reviewed 91 cases in Bahia, Brazil, during a 3 year period. Infections by HIV-1 (50%), HTLV-I (32%), and both (20%) were highly prevalent. Crusted or severe strongly and, to lesser degree, Co-infected patients had higher risk death (P= 0.01). forms predictive double retroviral (Norwegian) HTLV-I/II infection some studies [1]. northeastern state is...
Diarrhea due to intestinal microbial infections is a frequent manifestation among HIV-infected patients. It has been postulated that patients may have special types of infections, and immune activation from such parasites affect the progression HIV disease. To evaluate these associations, frequency was examined in Bahia, Brazil. determine potential impact presence parasitic on disease progression, retrospective study approach used. The medical charts 365 who had treated at AIDS Clinic...
Current HIV-1 viral-load assays are too expensive for resource-limited settings. In some countries, monitoring of antiretroviral therapy is now more than treatment itself. addition, commercial have shown shortcomings in quantifying rare genotypes.
The purpose of this study was to evaluate whether subdivision adult T-cell leukemia/lymphoma (ATL) on the basis clinical types, skin involvement, histologic features, cell size, and proliferative index (PI) clinically relevant. Skin lesions were present in 47 cases (67%). Five classified as primary cutaneous tumoral (PCT) type not included Shimoyama classification characterized by tumors absence systemic lymphocytosis, hypercalcemia. Mortality high (61/70 [87%]). overall median survival time...
Nosocomial bloodstream infections (nBSIs) are an important cause of morbidity and mortality the most frequent type nosocomial infection in pediatric patients.We identified predominant pathogens antimicrobial susceptibilities isolates patients (≤16 years age) Brazilian Prospective Surveillance for nBSIs at 16 hospitals from 12 June 2007 to 31 March 2010 (Br SCOPE project).In our study a total 2,563 cases nBSI were reported by participating Br project. Among these, 342 clinically significant...
Patients with AIDS under antiretroviral therapy often present metabolic problems associated HIV infection and its therapy, which can affect their quality of life. The knowledge on the potential benefits regular physical exercises for HIV-infected patients is limited.We conducted a clinical trial to evaluate impact activity life, anatomic disturbances, and/or changes in city Salvador, Brazil.Patients were randomly assigned monthly workshops (1-hour duration) discuss importance receive...
To describe the pattern and progression of central nervous system (CNS) lesions in microcephalic fetuses with suspected Zika virus (ZIKV) infection.In this prospective study Salvador, Brazil, we analyzed diagnosed microcephaly ZIKV infection after a routine primary care ultrasound scan between July 2015 February 2016 raised suspicion fetal microcephaly. The pregnancies were followed serial scans until delivery at one three main referral centers for abnormalities Brazil. Microcephaly was when...