A5051536147- Malaria Research and Control
- Mosquito-borne diseases and control
- Research on Leishmaniasis Studies
- Vibrio bacteria research studies
- Complement system in diseases
- Venomous Animal Envenomation and Studies
- Iron Metabolism and Disorders
- Renal Transplantation Outcomes and Treatments
- Hemoglobinopathies and Related Disorders
- Viral Infections and Vectors
- HIV Research and Treatment
- Vector-borne infectious diseases
- vaccines and immunoinformatics approaches
- Parasites and Host Interactions
- T-cell and B-cell Immunology
- Science and Education Research
- Insect symbiosis and bacterial influences
- Immune Response and Inflammation
- Indigenous Health and Education
- Organ Transplantation Techniques and Outcomes
- Cystic Fibrosis Research Advances
- Fish biology, ecology, and behavior
- Hepatitis B Virus Studies
- Aquaculture disease management and microbiota
- Hepatitis Viruses Studies and Epidemiology
Centro de Pesquisas Oncológicas
2013-2023
Universidade Federal de Rondônia
2012-2022
Instituto de Tecnologia e Pesquisa
2018
Fundação Oswaldo Cruz
2015
Faculdade de Medicina do ABC
2005-2013
Secretaria da Saúde
2008
Osaka Prefectural Institute of Public Health
1997
Universidade de Brasília
1984-1993
Cornell University
1987
Ministério da Saúde
1987
Treatment of Plasmodium vivax malaria requires the clearing asexual parasites, but relapse can be prevented only if dormant hypnozoites are cleared from liver (a treatment termed "radical cure"). Tafenoquine is a single-dose 8-aminoquinoline that has recently been registered for radical cure P. vivax.
Journal Article Epidemiology of American Cutaneous Leishmaniasis Due to Leishmania braziliensis brasiliensis Get access T. C. Jones, Jones From the Department Medicine, Division International Cornell University Medical College, New York, York; Brasilia, Bahia, Salvador, and Superintendencia Campagna, Brazilian Ministry Health, Brazil Search for other works by this author on: Oxford Academic PubMed Google Scholar W. D. Johnson, Jr., Jr. Please address requests reprints Dr. Warren 1300 York...
Malaria-induced sepsis is associated with an intense proinflammatory cytokinemia for which the underlying mechanisms are poorly understood. It has been demonstrated that experimental infection of humans Plasmodium falciparum primes Toll-like receptor (TLR)-mediated responses. Nevertheless, relevance this phenomenon during natural and, more importantly, by malaria mediates TLR hyperresponsiveness unclear. Here we show responses boosted in febrile patients P. . Microarray analyses...
Infection with Plasmodium vivax results in strong activation of monocytes, which are important components both the systemic inflammatory response and parasite control. The overall goal this study was to define role monocytes during P. malaria. Here, we demonstrate that vivax–infected patients display significant increase circulating were defined as CD14+CD16− (classical), CD14+CD16+ (inflammatory), CD14loCD16+ (patrolling) cells. While classical found be primary source pro-inflammatory...
Background The activation of innate immune responses by Plasmodium vivax results in effector cells and an excessive production pro-inflammatory cytokines that may culminate deleterious effects. Here, we examined the function neutrophils during acute episodes malaria. Materials Methods Blood samples were collected from P. vivax-infected patients at admission (day 0) 30–45 days after treatment with chloroquine primaquine. Expression markers cytokine levels produced highly purified monocytes...
Longitudinal entomological surveys were performed in Vila Candelária and adjacent rural locality of Bate Estaca concomitantly with a clinical epidemiologic malaria survey. is riverside periurban neighborhood Porto Velho, capital the state Rondônia Brazilian Amazon. High anopheline densities found accompanying peak rainfall, as reported areas region. Moreover, several minor peaks anophelines recorded between end dry season beginning next rainy season. These secondary related to permanent...
The study area in Rondônia was the site of extensive malaria epidemic outbreaks 19(th) and 20(th) centuries related to environmental impacts, with large immigration flows. present work analyzes transmission dynamics these areas propose measures for avoiding due construction two Hydroelectric Power Plants. A population based baseline demographic census a prevalence follow up were performed river side localities suburbs Porto Velho city its rural vicinity. quantification nature parasites...
The function and regulation of the immune response triggered during malaria is complex poorly understood, there a particular paucity studies conducted in humans infected with Plasmodium vivax. While it has been proposed that T-cell-effector responses are crucial for protection against blood-stage mice, mechanisms behind this remain understood. Experimental models have shown regulatory molecules, cytotoxic T-lymphocyte attenuator-4 (CTLA-4), lymphocyte activation gene-3 (LAG-3), programmed...
The adaptive immunity against Plasmodium vivax is thought to be essential limit parasite growth during asymptomatic malaria, preventing the occurrence of symptoms. However, mechanisms governing clinical infections are not understood. Here, we investigated cellular compartment in P. vivax-infected individuals (ASY) compared symptomatic patients (SY) and healthy donors (CTL). Our integrative analysis revealed a TH1-biased immune signature with expanded populations TH1 CD4+ T cells associated...
The clinical outcome of malaria depends on the delicate balance between pro-inflammatory and immunomodulatory cytokine responses triggered during infection. Despite numerous reports characterization plasma levels cytokines/chemokines, there is no consensus profile these mediators blood stage malaria. identification acute phase biomarkers might contribute to a better understanding disease, allowing use more effective therapeutic approaches prevent progression towards severe disease. In...
Individuals with asymptomatic infection due to Plasmodium vivax are posited be important reservoirs of malaria transmission in endemic regions. Here we studied a cohort P . patients suburban area the Brazilian Amazon. Overall 1,120 individuals were screened for and 108 (9.6%) had parasitemia detected by qPCR but not microscopy. Asymptomatic higher levels antibodies against similar hematological biochemical parameters compared uninfected controls. Blood from very low transmitted main local...
Cross sectional studies on malaria prevalence was performed in 2001, 2002, and 2004 Vila Candelária, an urban riverside area of Porto Velho, Rondônia, the Brazilian Western Amazon, followed by longitudinal surveys incidence. Candelária is a working class district, provided with electricity, water supply, basic sanitation. Previous preliminary indicated high incidence this community. At end year 2000 regular diagnostic treatment measures for were introduced, active search febrile cases among...
Flavivirus is a genus of arthropod-transmitted viruses the family Flaviviridae, and in Brazil, up to eleven different have been isolated. We collected blood from farmers municipality Theobroma, which located 320km City Porto Velho, former capital Brazilian State Rondônia. For viral isolation, we used newborn mouse brain, followed by RT-PCR with specific universal primers. obtained fragments 958bp 800bp length. Based on BLAST, these sequences were 91% similar sequence Cacipacore virus.
Após fazer uma análise da evolução malária na Amazônia brasileira, detalhando em particular a situação Rondônia e no município de Porto Velho, onde ocorreram episódios dramáticos epidemias passado, os autores apresentam o quadro atual prevalência nas áreas do Vale Rio Madeira, que sofrerão impactos com construção das hidrelétricas Santo Antônio Jirau, alertam sobre ribeirinhas. Nessas áreas, observam-se alta incidência vivax falciparum, presença grande número portadores assintomáticos...
Abstract Background There is general international agreement that the importance of vivax malaria has been neglected, and there a need for new treatment approaches in an effort to progress towards control elimination Latin America. This open label randomized clinical trial evaluated efficacy safety three regimens using either one two fixed dose artemisinin-based combinations or chloroquine combination with short course primaquine (7–9 days: total 3–4.2 mg/kg) Brazil. The primary objective...
Reduction in the number of circulating blood lymphocytes (lymphocytopaenia) has been reported during clinical episodes malaria and is normalized after treatment with anti-malaria drugs. While this phenomenon well established infection, underlying mechanisms are still not fully elucidated. In present study, occurrence apoptosis its pathways CD4+ T cells was investigated naturally Plasmodium vivax-infected individuals from a Brazilian endemic area (Porto Velho - RO).Blood samples were...
A malaria survey was conducted in an area of high transmission (Costa Marques, Rondonia, Brazil) to determine the prevalence asymptomatic parasitemia and its clinical significance. Most people surveyed were immigrants who had lived endemic < 5 years. The easy access free diagnostic treatment services at Malaria Clinic town Costa Marques. plasmodial 344 22%. There 36 individuals with infections among 77 parasitemic patients. During two days following initial examination, 19 ofthe...
Em Rondônia, prevê-se a construção de mais duas usinas hidrelétricas (UHE) no rio Madeira, montante da cidade Porto Velho, Brasil (de Santo Antônio e Jirau). O objetivo deste trabalho foi analisar prevalência malária antes do início implantação das obras civis fazer considerações sobre os impactos doença com o ingresso milhares trabalhadores agregados atraídos pelas oportunidades emprego comércio. Os resultados obtidos mostram que se faz presente em toda região, variados graus prevalência....
For a long time, the role of CD8+ T cells in blood-stage malaria was not considered important because erythrocytes do express major histocompatibility complex (MHC) class I proteins. While recent evidences suggest that may play an during erythrocytic phase infection by eliminating parasites, might also contribute to modulate host response through production regulatory cytokines. Thus, is unclear. Here, we report phenotypic profiling subsets from patients with uncomplicated symptomatic P....
Uma investigação a respeito do que população local pensa sobre vários aspectos da leishmaniose mucocutânea foi realizada em Três Braços, Bahia, uma área de alta prevalência infecção por Leishmania braziliensis braziliensis. Os resultados obtidos indicam essa tem um entendimento razoavelmente bom alguns epidemiológicos e tratamento dessa doença, mas demonstram seu pouco conhecimento concernente à etiologia prevenção. Esses dados poderão ser valiosos, no futuro, planejamento controle...
We evaluated rudimentary cesspits as potential breeding sites for the mosquito Aedes aegypti and production compared to those officially designated common (CBS). In November December of 2009, immature forms insect were collected in water samples well CBS, latter being any object that potentially accumulates such used tires, flower pots solid waste disposal. Samplings performed urban areas two municipalities Rondonia State Brazilian Western Amazon. Immature adult Ae. observed confirming these...
A rounding cell-forming--GC strain, which is a variant of syncytial giant cell-forming herpes simplex virus (+GC Miyama strain), was highly attenuated for Swiss, BALB/c nu/nu, and nu/+ mice, whereas +GC virulent to all the mice tested. -GC were antigenically indistinguishable from each other by cross-neutralization cross-immunization. Immunosuppression induced cyclophosphamide converted nonlethal infection into fatal infection. replication in tissue culture more effectively suppressed spleen...