A5007228634- Toxoplasma gondii Research Studies
- Research on Leishmaniasis Studies
- Diabetes Management and Research
- Immunotherapy and Immune Responses
- Herpesvirus Infections and Treatments
- Neutropenia and Cancer Infections
- Diabetes Treatment and Management
- Microbial infections and disease research
- Toxin Mechanisms and Immunotoxins
- Immune Response and Inflammation
- Diabetes and associated disorders
- Trypanosoma species research and implications
- Microbial Metabolic Engineering and Bioproduction
- Gene Regulatory Network Analysis
- Nail Diseases and Treatments
- Hematopoietic Stem Cell Transplantation
- Blood disorders and treatments
- Macrophage Migration Inhibitory Factor
- Immune Cell Function and Interaction
- Eosinophilic Disorders and Syndromes
- Pancreatic function and diabetes
- Rabies epidemiology and control
- Health Systems, Economic Evaluations, Quality of Life
- T-cell and Retrovirus Studies
- Cytomegalovirus and herpesvirus research
AstraZeneca (United Kingdom)
2024
Jones Institute
2021-2023
Virginia Tech
2014-2019
Mercer University
2014
University of Chicago
2013
Cornell University
1974-2001
UCLA Health
2000
Jain PharmaBiotech (Switzerland)
1993-1994
Universidade Federal da Bahia
1994
Center for Infectious Disease Research
1994
Electron microscope methods have been used to study delivery of macrophage primary or secondary lysosomal contents phagocytic vacuoles containing living dead toxoplasmas. Secondary lysosomes were labeled by culturing the cells in colloidal thorium dioxide (thorotrast) ferritin. Acid phosphatase cytochemistry was employed for detection as well constituents. These various labels present nearly all toxoplasmas killed with glutaraldehyde, those parasites undergoing degeneration 1 hr after uptake...
During an epidemiological study of visceral leishmaniasis in endemic region Brazil. new perspectives emerged on a subclinical form the disease. A group 86 children with antibody to Leishmania were identified. None these had history leishmaniasis. The segregated into four groups: One remained asymptomatic (n = 20). whereas another developed classic kala-azar within weeks index serology 15). remaining 51 patients initially disease; 13 (25%) progressed (mean. five months). others (75%) resolved...
The epidemiology, clinical patterns, and risk factors for visceral leishmaniasis were prospectively studied in an endemic area of Brazil. prevalence disease was 3.1% children less than 15 years age, the annual incidence 4.3 cases per 1,000 children. number with fluctuated yearly seasonally, distribution varied within area. Risk included young age (median, three years) malnutrition before onset disease. Intestinal parasitism, recent migration into area, house location did not influence...
The lymphocytes from eight patients with active visceral leishmaniasis (VL), a disease associated marked immunologic dysfunction, were examined for ability to produce interleukin 2 (IL-2) and gamma interferon during in vitro cultivation. It was found that both IL-2 production, response leishmania antigen, absent the disease, but restored after successful chemotherapy. Untreated VL produced when stimulated phytohemagglutinin (PHA). Six either cutaneous or mucosal leishmaniasis, not...
Advances in diabetes technology have transformed the treatment paradigm for type 1 diabetes, yet burden of disease is significant. We report on a pivotal safety study first tubeless, on-body automated insulin delivery system with customizable glycemic targets.This single-arm, multicenter, prospective enrolled 112 children (age 6-13.9 years) and 129 adults 14-70 years). A 2-week standard therapy phase (usual regimen) was followed by 3 months delivery. Primary outcomes were incidence severe...
Journal Article Epidemiology of American Cutaneous Leishmaniasis Due to Leishmania braziliensis brasiliensis Get access T. C. Jones, Jones From the Department Medicine, Division International Cornell University Medical College, New York, York; Brasilia, Bahia, Salvador, and Superintendencia Campagna, Brazilian Ministry Health, Brazil Search for other works by this author on: Oxford Academic PubMed Google Scholar W. D. Johnson, Jr., Jr. Please address requests reprints Dr. Warren 1300 York...
Macrophage, fibroblast, and HeLa cell cultures have been infected with Toxoplasma gondii, observations made on parasite entry fate. A special procedure was devised for studying the of toxoplasmas by electron microscopy. Toxoplasmas were centrifuged onto cells in cold; fixation 1-3 min after warming yielded specimens showing numerous examples parasites process entering cells. The mechanism into macrophages, fibroblasts, all cases phagocytosis. Micropseudopods extended to envelop attached a...
Studies were designed to examine skin test responses leishmanial antigens in American visceral leishmaniasis (AVL) Brazil. We found that after recovery from AVL, patients had positive delayed hypersensitivity reactions Leishmania. Different amounts of a soluble extract obtained Leishmania donovani chagasi promastigotes compared with whole L. d. persons past AVL. The most effective preparations tested contained 25 and 50 µg protein. These produced 95%–100% the individuals protein dose was...
A model was developed for studying the interaction between Pneumocystis, rat-derived cells, and humoral factors. Pneumocystis were obtained in large quantity by bronchial lavage of steroid-treated rats. The trophozoite predominant form obtained, it could readily be recognized phase contrast microscopy. Organisms maintained a typical morphology at least 3 days culture, 10-20% took up radiolabeled nucleotides. adhered to cell surfaces similar manner alveolar macrophages from or normal rats,...
Studies have been made on humoral and cellular immune respones in mice immunized with an attenuated strain of Toxoplasma gondii. Heat-inactivated antitoxoplasma serum did not cause morphologic changes the organisms, but markedly influence their interactions host cells. exposed to antibody were no longer capable entering fibroblasts or HeLa They readily engulfed by macrophages, treatment strikingly altered intracellular fate parasites leading killing digestion toxoplasmas phagolysosomes....
"Evaluation of the Micro Enzyme-Linked Immunosorbent Assay (ELISA) for Antibodies in American Visceral Leishmaniasis: Antigen Selection Detection Infection-Specific Responses" published on Jan 1986 by The Society Tropical Medicine and Hygiene.
Long-term culturing of Toxoplasma gondii cysts was accomplished in vitro association with murine astrocytes and intermittent additions gamma interferon to the media. Phase-contrast microscopy used follow stages cyst development, electron confirmed presence morphologic characteristics T. cysts. formed had a single trilaminar membrane during both intracellular extracellular existence contained amorphous electron-dense material either throughout or uniform layer under membrane. The bradyzoites...
Terbinafine (Lamisil) is the newest compound within a class of antimycotic drugs called allylamines. It active against broad range dermatophytes and yeasts exerts its fungicidal action by inhibiting squalene epoxidation during sterol synthesis in fungal membranes. Effective therapy (complete cure or mycological with minimal signs symptoms) has been observed 70-90% 1200 patients treated topically 1% cream for tinea corporis/cruris, pedis, cutaneous candidiasis pityriasis versicolor. Cure...
Methods have been devised for establishing infection in vitro of mouse macrophages and fibroblasts with Mycoplasma pulmonis. The mycoplasmas attached to the cells under appropriate cultural conditions grew into a lawn microorganisms covering most cell surface. abundantly on cultured minimal essential medium containing 20% fetal calf serum; supplementation this heart infusion broth was necessary obtain similar growth macrophages. these appeared be essentially an extracellular process; only...
The diagnosis of acute toxoplasmosis usually depends on serology, yet little data are available to compare the relative usefulness various serologic tests after onset illness. Sabin-Feldman dye test (DT), IgM immunofluorescent antibody (IgM-IFA) test, soluble antigen complement-fixation (CF) and indirect hemagglutination (IHA) were performed serial serum specimens from 27 previously healthy patients, each whom could identify date illness within two weeks. IgM-IFA titers greater than or equal...
AimsTo evaluate psychosocial outcomes for adults with type 1 diabetes (T1D) using the tubeless Omnipod® 5 Automated Insulin Delivery (AID) System.MethodsA single-arm, multicenter (across United States), prospective safety and efficacy study of AID system included 115 T1D. Participants aged 18–70 years completed questionnaires assessing – distress (T1-DDS), hypoglycemic confidence (HCS), well-being (WHO-5), sleep quality (PSQI), insulin delivery satisfaction (IDSS), treatment (DTSQ),...
The Omnipod
Studies have been made on factors which influence attachment of Mycoplasma pulmonis to the surface mouse macrophages in vitro, and determine whether or not attached microorganisms are ingested.
Seventy-nine patients with cutaneous (62) or mucosal (17) infection Leishmania (Viannia) braziliensis in Três Braços, Bahia, Brazil, were followed for at least 4 years after initiating treatment antimony. Cutaneous relapses occurred (10%), relapse (3%), and disease (17%). It is concluded that (cutaneous mucosal) rare adequate antimony therapy no definite prediction of (clinical, serological by skin reaction) possible.
Journal Article Pityrosporum ovale (Malassezia furfur) as the causative agent of seborrhoeic dermatitis: new treatment options Get access J. FAERGEMANN, FAERGEMANN Department Dermatology, Sahlgrenska University Hospital, Gothenburg, Sweden Dr Faergemann, S‐413 45 Sweden. Search for other works by this author on: Oxford Academic Google Scholar T.C. JONES, JONES Sandoz Pharma AG, Basel, Switzerland O. HETTLER, HETTLER Y. LORIA SA, Rueil‐Malmaison, France British Volume 134, Issue s46, 1 June...
Journal Article Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor Reverses Neutropenia and Reduces Secondary Infections in Visceral Leishmaniasis Get access R. Badaro, Badaro Federal University of BahiaSalvador, BrazilDivision International Medicine, Cornell Medical CollegeNew York, New YorkClinical Research, Sandoz Pharma Ltd.Basel, SwitzerlandSeattle Biomedical Research InstituteWashington Search for other works by this author on: Oxford Academic PubMed Google Scholar C....