A5029646107- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Parasites and Host Interactions
- Eosinophilic Disorders and Syndromes
- Monoclonal and Polyclonal Antibodies Research
- Psychodrama and Leishmaniasis Studies
- Insect and Pesticide Research
- Parasite Biology and Host Interactions
- Leprosy Research and Treatment
- Maternal and Neonatal Healthcare
- T-cell and Retrovirus Studies
- Toxin Mechanisms and Immunotoxins
- Myxozoan Parasites in Aquatic Species
- Infectious Diseases and Mycology
- Paraoxonase enzyme and polymorphisms
- Leptospirosis research and findings
- Blood Coagulation and Thrombosis Mechanisms
- Synthesis and biological activity
- Helminth infection and control
- History of Medicine and Tropical Health
- Synthesis and Characterization of Heterocyclic Compounds
- Urticaria and Related Conditions
- Insect symbiosis and bacterial influences
- Reproductive System and Pregnancy
- Moringa oleifera research and applications
Fundação Oswaldo Cruz
2011-2023
Centro Universitário de João Pessoa
2010
Fundação de Tecnologia do Estado do Acre
2009
Universidade Federal do Maranhão
1994-2006
Universidade Federal da Bahia
1992-2006
Pan American Health Organization (Brasil)
2001
Universidade de Brasília
1984-1998
Universidade Federal de São Paulo
1996-1998
Hôpital Broussais
1991-1992
Université Claude Bernard Lyon 1
1992
Journal Article Epidemiology of American Cutaneous Leishmaniasis Due to Leishmania braziliensis brasiliensis Get access T. C. Jones, Jones From the Department Medicine, Division International Cornell University Medical College, New York, York; Brasilia, Bahia, Salvador, and Superintendencia Campagna, Brazilian Ministry Health, Brazil Search for other works by this author on: Oxford Academic PubMed Google Scholar W. D. Johnson, Jr., Jr. Please address requests reprints Dr. Warren 1300 York...
A protective or deleterious role of CD8(+)T cells in human cutaneous leishmaniasis (CL) has been debated. The present report explores the participation disease pathogenesis as well parasite killing. accumulated CL lesions suggested by a higher frequency CD8(+)CD45RO(+)T and CD8(+)CLA(+)T compared with peripheral blood mononuclear cells. Upon Leishmania braziliensis restimulation, most from lesion expressed cytolytic markers, CD107a granzyme B. Granzyme B expression positively correlated size...
Leishmaniasis remains a serious public health problem in several parts of the developing world. Effective prophylactic measurements are hampered by imprecise comprehension different aspects disease, including its immunoregulation. A better immunoregulation human VL may be useful both for designing and evaluating immunoprophylaxis.To explore immunoregulatory mechanisms, 20 visceral leishmaniasis (VL) patients were evaluated during active disease at periods up to one year after treatment...
Cutaneous leishmaniasis (CL) is a worldwide disease endemic in several regions of the globe. The hallmark CL skin ulcers likely driven by efforts immune system to control Leishmania growth. Cytokines, such as tumor necrosis factor (TNF) and interferon-gamma can progression animal models. Nevertheless, impact these cytokines ulcer outcome not well established humans. In this study, 96 patients from an area braziliensis were enrolled for follow-up study that consisted clinical immunological...
Diffuse cutaneous leishmaniasis (DCL) is a rare clinical manifestation of tegumentary leishmaniasis. The molecular mechanisms underlying DCL pathogenesis remain unclear, and there no efficient treatment available. This study investigated the systemic in situ expression inflammatory response that might contribute to suppression DCL. plasma levels arginase I, ornithine decarboxylase (ODC), transforming growth factor β (TGF-β), prostaglandin E2 (PGE2) were higher patients with DCL, compared...
A trophic network involving molds, invertebrates, and vertebrates, ancestrally adapted to the palm tree (Attalaea phalerata) microhabitat, maintains enzootic Trypanosoma cruzi infections in Amazonian county Paço do Lumiar, state of Maranhão, Brazil. We assessed seropositivity for T. human population county, searched trees triatomines that harbor these infections, gathered demographic, environmental, socioeconomic data. Rhodnius pictipes R. neglectus palm-tree frond clefts or houses were...
Abstract Background. Diffuse cutaneous leishmaniasis (DCL) is a rare manifestation of human leishmaniasis, characterized by multiple, slowly progressive nodules or plaques without ulceration, involving almost the entire body. It has been suggested, that DCL results from lack cell‐mediated immunity to leishmanial antigen, leading uncontrolled parasite growth. Methods. We have performed detailed clinical, histopathologic, and immunologic investigations in six patients with DCL. Biopsies were...
Various factors have been associated with a predisposition to the development of clinical American visceral leishmaniasis (AVL). However, little information is available about that predispose asymptomatic infection. To identify risk infection, study was carried out between July 1997 and June 1998 on children aged 0-5 years in districts Vila Nova Bom Viver municipality Raposa island São Luís, State Maranhão, Brazil. A questionnaire containing socioeconomic, demographic epidemiological data...
Background Exposure to Leishmania induces a humoral immune response that can be used as marker of parasite exposure. Methodology/Principal Findings Herein, ELISA was screen sera from patients with Tegumentary Leishmaniasis (TL) against different L. infantum-chagasi-derived recombinant proteins (rHSP70, rH2A, rH2B, rH3, rH4 and rKMP11). Among the proteins, rHSP70 rH2A showed best reactivity human obtained endemic areas TL. Receiver-Operator Characteristics (ROC) curve analysis identify...
Localised cutaneous leishmaniasis (LCL) is the most common form of characterised by single or multiple painless chronic ulcers, which commonly presents with secondary bacterial infection. Previous culture-based studies have found staphylococci, streptococci, and opportunistic pathogenic bacteria in LCL lesions, but there been no comparisons to normal skin. In addition, this approach has strong bias for determining composition. The present study tested hypothesis that communities lesions...
Abstract A trophic network involving molds, invertebrates, and vertebrates, ancestrally adapted to the palm tree (Attalaea phalerata) microhabitat, maintains enzootic Trypanosoma cruzi infections in Amazonian county Paço do Lumiar, state of Maranhão, Brazil. We assessed seropositivity for T. human population county, searched trees triatomines that harbor these infections, gathered demographic, environmental, socioeconomic data. Rhodnius pictipes R. neglectus palm-tree frond clefts or houses...
Os autores analisam material de biópsias 378 casos Leishmaniose Tegumentar, causada por Leishmania braziliensis braziliensis, da localidade endêmica Três Braços (Estado Bahia). O parásitos, embora escassos, foram encontrados em 63,7% dos forma cutânea e 37,5% mucosa. As alterações dérmicas ou do córion mucosa permitiram identificar cinco padrões histopatológicos: 1) Reação Exsudativa Celular, constituída um infiltrado histiolinfoplasmocitário; 2) Necrótica, na qual ocorre uma necrose no seio...
Numa análise de 57 pacientes o acometimento da mucosa foi mais comumente observado em homens (77%) na terceira década vida, embora fosse grande a variação das idades e ocorrendo mesmo duas crianças. Com exceção nove (16%) todos os outros tinham sinais leishmaniose cutânea sendo que somente oito (14%) lesão era ativa. O do nariz 100% 19 apresentavam lesões múltiplas 92% 38 apresentando uma única lesão. A faringe, palato, laringe lábio superior foram afetados nesta experiência. 42% dos com...
Seventy-nine patients with cutaneous (62) or mucosal (17) infection Leishmania (Viannia) braziliensis in Três Braços, Bahia, Brazil, were followed for at least 4 years after initiating treatment antimony. Cutaneous relapses occurred (10%), relapse (3%), and disease (17%). It is concluded that (cutaneous mucosal) rare adequate antimony therapy no definite prediction of (clinical, serological by skin reaction) possible.
Diffuse cutaneous leishmaniasis (DCL) is a rare clinical manifestation of leishmaniasis, characterized by an inefficient parasite-specific cellular response and heavily parasitized macrophages. In Brazil, Leishmania (Leishmania) amazonensis the main species involved in DCL cases. experimental model, recognition phosphatidylserine (PS) molecules exposed on surface amastigotes forms L. inhibits inflammatory infected macrophages as strategy to evade host immune surveillance. this study, we...
In this study, we used proteomics and biological network analysis to evaluate the potential processes components present in identified proteins of biopsies from cutaneous leishmaniasis (CL) patients infected by Leishmania braziliensis comparison with normal skin. We 59 differently expressed samples Biological employing showed presence networks that may be involved cell death mediated cytotoxic T lymphocytes. After immunohistochemical analyses, expression caspase-9, caspase-3, granzyme B was...
Envolvimento da função renal em pacientes com leishmaniose visceral (calazar). Apresenta-se estudo prospectivo de 11 LV, o intuito verificar as repercussões clínico-laboratoriais na doença. Realizou-se análises laboratoriais das amostras sangue e urina, colhidas logo após confirmação diagnóstica, através do encontro leishmanias no aspirado médula óssea. Dois (18%) apresentaram complicações associadas a LV. Cinco (45,4%) hematúria macroscópica um caso (No.9) manifestações clínicas compatíveis...
Realizou-se estudo prospectivo com 648 crianças de zero a cinco anos no município da Raposa-MA, julho/97 junho/98, o objetivo avaliar as características infecção por L.(L.)chagasi e verificar se existe associação entre desnutrição assintomática. Utilizou-se questionário dados socioeconômicos, ambientais hábitos vida; realizou-se Intradermorreação Montenegro(IDRM) antígeno L. amazonensis Enzyme Linked Immunosorbant Assay(ELISA) para detectar infecção, exame antropométrico. A prevalência...