A5062721744- SARS-CoV-2 and COVID-19 Research
- Malaria Research and Control
- COVID-19 Clinical Research Studies
- Burkholderia infections and melioidosis
- Vaccine Coverage and Hesitancy
- Tuberculosis Research and Epidemiology
- Mosquito-borne diseases and control
- COVID-19 and healthcare impacts
- Hematological disorders and diagnostics
- Drug-Induced Ocular Toxicity
- Sepsis Diagnosis and Treatment
- Infection Control and Ventilation
- COVID-19 and Mental Health
- Hepatitis B Virus Studies
- SARS-CoV-2 detection and testing
- Mycobacterium research and diagnosis
- Pneumonia and Respiratory Infections
- COVID-19 diagnosis using AI
- COVID-19 Impact on Reproduction
- Long-Term Effects of COVID-19
- Drug Transport and Resistance Mechanisms
- Respiratory viral infections research
- Neonatal Health and Biochemistry
- Animal Virus Infections Studies
- Adrenal Hormones and Disorders
Intarcia Therapeutics (United States)
2025
GlaxoSmithKline (United Kingdom)
2015-2024
Northwick Park Hospital
2018-2024
GlaxoSmithKline (India)
2017-2024
AstraZeneca (United Kingdom)
2011-2023
Frimley Park Hospital
2022
University of Cambridge
2010-2019
University of Amsterdam
2010-2019
University of Oxford
2010-2019
Amsterdam University Medical Centers
2019
The monoclonal-antibody combination AZD7442 is composed of tixagevimab and cilgavimab, two neutralizing antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that have an extended half-life been shown to prophylactic therapeutic effects in animal models. Pharmacokinetic data humans indicate has approximately 90 days.In ongoing phase 3 trial, we enrolled adults (≥18 years age) who had increased risk inadequate response vaccination disease 2019 (Covid-19), exposure...
Treatment of Plasmodium vivax malaria requires the clearing asexual parasites, but relapse can be prevented only if dormant hypnozoites are cleared from liver (a treatment termed "radical cure"). Tafenoquine is a single-dose 8-aminoquinoline that has recently been registered for radical cure P. vivax.
Tafenoquine, a single-dose therapy for Plasmodium vivax malaria, has been associated with relapse prevention through the clearance of P. parasitemia and hypnozoites, termed "radical cure."
Abstract New tuberculosis treatments are needed to address drug resistance, lengthy treatment duration and adverse reactions of available agents. GSK3036656 (ganfeborole) is a first-in-class benzoxaborole inhibiting the Mycobacterium leucyl-tRNA synthetase. Here, in this phase 2a, single-center, open-label, randomized trial, we assessed early bactericidal activity (primary objective) safety pharmacokinetics (secondary objectives) ganfeborole participants with untreated,...
Birmingham is the largest UK city after London, and central has an annual tuberculosis incidence of 80 per 100,000. We examined seasonality sunlight as drivers incidence. Hours sunshine are seasonal, exposure necessary for production vitamin D by body plays a role in host response to tuberculosis.We performed ecological study that from Dec 1981 Nov 2009, using publicly-available data statutory notifications, related this seasons hours (UK Meteorological Office data) unmeasured component...
Challenges in classifying recurrent Plasmodium vivax infections constrain surveillance of antimalarial efficacy and transmission. Recurrent may arise from activation dormant liver stages (relapse), blood-stage treatment failure (recrudescence) or reinfection. Molecular inference familial relatedness (identity-by-descent IBD) can help resolve the probable origin recurrences. As whole genome sequencing P. remains challenging, targeted genotyping methods are needed for scalability. We describe...
Patients with diabetes mellitus are more prone to bacterial sepsis, but there conflicting data on whether outcomes worse in diabetics after presentation sepsis. Glyburide is an oral hypoglycemic agent used treat mellitus. This K(ATP)-channel blocker and broad-spectrum ATP-binding cassette (ABC) transporter inhibitor has broad-ranging effects the immune system, including inhibition of inflammasome assembly would be predicted influence host response infection.We studied a cohort 1160 patients...
A 21-year survey conducted in northeast Thailand of antimicrobial resistance to parenteral drugs used treat melioidosis identified 24/4,021 (0.6%) patients with one or more isolates resistant ceftazidime (n = 8), amoxicillin-clavulanic acid 4), both 12). Two cases were at admission, and the remainder detected a median 15 days after starting therapy. Resistance carbapenem was not detected. These findings support current prescribing recommendations for melioidosis.
Tafenoquine (TQ) and primaquine (PQ) are 8-aminoquinolines (8-AQ) with anti-hypnozoite activity against vivax malaria. PQ is the only FDA-approved medicine for preventing relapsing Plasmodium infection TQ currently in phase 3 clinical trials same indication. Recent studies have provided evidence that cytochrome P450 (CYP) metabolism via CYP2D6 plays a role efficacy P. suggested this effect may extend to other 8-AQs, including TQ. Here, retrospective pharmacogenetic (PGx) investigation was...
Melioidosis (Burkholderia pseudomallei infection) is a common cause of community-acquired sepsis in Northeast Thailand and northern Australia. B. soil saprophyte endemic to Southeast Asia The clinical presentation melioidosis may mimic tuberculosis (both chronic suppurative lesions unresponsive conventional antibiotics both commonly affect the lungs). two diseases have overlapping risk profiles (e.g., diabetes, corticosteroid use), Mycobacterium are intracellular pathogens. There however...
This phase 3 trial assessed AZD7442 (tixagevimab/cilgavimab) for post-exposure prophylaxis against symptomatic coronavirus disease 2019 (COVID-19).Adults without prior severe acute respiratory syndrome 2 (SARS-CoV-2) infection or COVID-19 vaccination were enrolled within 8 days of exposure to a SARS-CoV-2-infected individual and randomized 2:1 single 300-mg dose (one 1.5-mL intramuscular injection each tixagevimab cilgavimab) placebo. Primary end points safety first post-dose SARS-CoV-2...
Abstract Background Although tuberculosis (TB) is a curable disease, treatment complex and prolonged, requiring considerable commitment from patients. This study aimed to understand the common perspectives of TB patients across Brazil, Russia, India, China, South Africa throughout their disease journey, including emotional, psychological, practical challenges that families face. Methods qualitative market research was conducted between July 2020 February 2021. Eight each country ( n = 40)...
Abstract Traditionally, patient travel history has been used to distinguish imported from autochthonous malaria cases, but the dormant liver stages of Plasmodium vivax confound this approach. Molecular tools offer an alternative method identify, and map cases. Using machine learning approaches incorporating hierarchical fixation index decision tree analyses applied 799 P. genomes 21 countries, we identified 33-SNP, 50-SNP 55-SNP barcodes (GEO33, GEO50 GEO55), with high capacity predict...
Background Burkholderia pseudomallei infection (melioidosis) is an important cause of community-acquired Gram-negative sepsis in Northeast Thailand, where it associated with a ∼40% mortality rate despite antimicrobial chemotherapy. We showed previous cohort study that patients taking glyburide ( = glibenclamide) prior to admission have lower and attenuated inflammatory responses compared not glyburide. sought define the mechanism underlying this observation murine model melioidosis. Methods...