A5027741209- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Malaria Research and Control
- HIV Research and Treatment
- Virology and Viral Diseases
- Viral Infections and Outbreaks Research
- Immunotherapy and Immune Responses
- COVID-19 epidemiological studies
- Global Maternal and Child Health
- SARS-CoV-2 and COVID-19 Research
- vaccines and immunoinformatics approaches
- Insect symbiosis and bacterial influences
- COVID-19 Impact on Reproduction
- Immune Cell Function and Interaction
- Zoonotic diseases and public health
- Complement system in diseases
- Monoclonal and Polyclonal Antibodies Research
- Electrochemical sensors and biosensors
- Parasites and Host Interactions
- Cytomegalovirus and herpesvirus research
- COVID-19 Clinical Research Studies
- Virus-based gene therapy research
- Electrochemical Analysis and Applications
- Vector-borne infectious diseases
- Respiratory viral infections research
Fundação Oswaldo Cruz
2016-2025
University of Pittsburgh
2016-2025
Universidade Estadual de Londrina
2025
Fundação de Medicina Tropical
2024
Universidade Federal de Minas Gerais
2024
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2024
Universidade Federal do Rio de Janeiro
2020
Clínica Girona
2020
Institut de Recherche Vaccinale
2014-2017
Universidade Estadual de Feira de Santana
2017
To provide an initial description of the congenital syndrome presumably associated with infection by Zika virus compared other syndromes including infections established etiologies.We overview a published case series 35 cases, clinical 104 and unpublished reports laboratory findings describing cases diagnosed since beginning epidemic microcephaly in Brazil.About 60% to 70% mothers report rash during pregnancy; mainly first trimester. Principal features are microcephaly, facial...
This report describes the characteristics of infants who were exposed to Zika virus in utero and born with abnormalities central nervous system, as seen on computed tomography.
The clinical outcomes associated with Zika virus (ZIKV) in the Americas have been well documented, but other aspects of pandemic, such as attack rates and risk factors, are poorly understood. We prospectively followed a cohort 1453 urban residents Salvador, Brazil, and, using an assay that measured immunoglobulin G3 (IgG3) responses against ZIKV NS1 antigen, we estimated 73% individuals were infected during 2015 outbreak. Attack spatially heterogeneous, varying by factor 3 within community...
A low-cost, equipment-free rapid antigen test distinguishes dengue virus serotypes and Zika in patient sera without detectable cross-reactivity.
Abstract Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral RNA (vRNA) is detected in the bloodstream of some patients with disease 2019 (COVID-19), but it not clear whether this RNAemia reflects viremia (ie, virus particles) and how relates to host immune responses outcomes. Methods SARS-CoV-2 vRNA was quantified plasma samples from observational cohorts 51 COVID-19 including 9 outpatients, 19 hospitalized (non–intensive care unit [ICU]), 23 ICU patients. levels...
BackgroundButantan–Dengue Vaccine (Butantan-DV) is an investigational, single-dose, live, attenuated, tetravalent vaccine against dengue disease, but data on its overall efficacy are needed.MethodsIn ongoing phase 3, double-blind trial in Brazil, we randomly assigned participants to receive Butantan-DV or placebo, with stratification according age (2 6 years, 7 17 and 18 59 years); 5 years of follow-up planned. The objectives the were evaluate symptomatic, virologically confirmed any...
Background Dengue virus (DENV) was reintroduced into Brazil in 1986 and by 1995 it had spread throughout the country. In 2007 number of dengue hemorrhagic fever (DHF) cases more than doubled a shift age distribution reported. While previously majority DHF occurred among adults, 53% children under 15 years old. The reasons for this have not been determined. Methods Findings Age stratified cross-sectional seroepidemiologic survey conducted Recife, 2006. Serostatus determined ELISA based...
Anti-Flavivirus antibodies are highly cross-reactive and may facilitate Zika virus (ZIKV) infection through the antibody-dependent enhancement (ADE) mechanism. We demonstrate that dengue-specific enhance of a primary Brazilian ZIKV isolate in FcγRII-expressing K562 cell line. In addition, we serum samples from dengue-immune pregnant women enhanced infection. These findings highlight need for epidemiological studies animal models to further confirm role ADE development congenital neurological...
To estimate the risk of microcephaly in babies born to women infected by Zika virus during pregnancy Brazil an epidemic between 2015 and 2016.We obtained data on number notified confirmed cases each Brazilian state November October 2016 from health ministry. For Pernambuco State, one hardest hit, weekly were available August for different definitions microcephaly. The absolute was calculated using average live births reported corresponding time period 2012 2014 assuming two infection rates:...
A rapid, specific, sensitive, and inexpensive method has been developed that detects RNA from a Zika virus strain associated with the current outbreak.
Zika virus (ZIKV) infection during pregnancy is associated with microcephaly, a congenital malformation resulting from neuroinflammation and direct effects of replication on the developing central nervous system (CNS). However, exact changes in affected CNS remain unknown. Here, we show by transcriptome analysis (at 48 hours post-infection) multiplex immune profiling that human induced-neuroprogenitor stem cells (hiNPCs) respond to ZIKV strong induction type I interferons (IFNs) several IFNs...
The complement system, a key component that links the innate and adaptive immune responses, has three pathways: classical, lectin, alternative pathways. In present study, we have analyzed levels of various components in blood samples from dengue fever (DF) hemorrhagic (DHF) patients found level activation is associated with disease severity.Patients DHF had lower factor 3 (C3; p = 0.002) increased C3a, C4a C5a (p<0.0001) when compared to those less severe form, DF. There were no significant...
Genetic variation and rapid evolution are hallmarks of RNA viruses, the result high mutation rates in replication selection mutants that enhance viral adaptation, including escape from host immune responses. Variability is uneven across genome because mutations resulting a deleterious effect on fitness restricted. viruses thus marked by protein sites permissive to multiple critical structure-function evolutionarily robust highly conserved. Identification characterization historical dynamics...
Dengue is a globally expanding disease caused by infection with dengue virus (DENV) that ranges from febrile illness to acute serious complications. Secondary predisposes individuals more severe disease, and B lymphocytes may play role in this phenomenon through production of Ab enhance infection. To better define the cell response during dengue, we analyzed peripheral cells an adult Brazilian hospital cohort primary secondary DENV infections varying clinical severity. Circulating patients...
The burden of dengue continues to increase globally, with an estimated 100 million clinically apparent infections occurring each year. Although most are asymptomatic, patients can present a wide spectrum clinical symptoms ranging from mild febrile illness through severe manifestations bleeding, organ impairment, and hypovolaemic shock due systemic vascular leak syndrome. Clinical diagnosis identification which likely develop disease remain challenging. This study aims improve management...
Zika virus (ZIKV) emerged in Brazil 2015, which was followed by an increase of Guillain-Barre Syndrome (GBS) cases. We report the epidemiological, clinical, and laboratory findings first six neurological cases associated with ZIKV seen a reference neurology hospital Pernambuco, Brazil. In all cases, detected serum and/or cerebrospinal fluid (CSF) samples. this case series, four were defined as GBS, one acute disseminated encephalomyelitis (ADEM) other encephalitis. RT-PCR isolation...