A5075557942- Hemoglobinopathies and Related Disorders
- Hemophilia Treatment and Research
- Iron Metabolism and Disorders
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Blood groups and transfusion
- Chronic Myeloid Leukemia Treatments
- Erythrocyte Function and Pathophysiology
- Complement system in diseases
- Blood Coagulation and Thrombosis Mechanisms
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Venous Thromboembolism Diagnosis and Management
- Acute Lymphoblastic Leukemia research
- Mosquito-borne diseases and control
- Platelet Disorders and Treatments
- Malaria Research and Control
- Eosinophilic Disorders and Syndromes
- Atrial Fibrillation Management and Outcomes
- Prenatal Screening and Diagnostics
- Viral Infections and Vectors
- Blood transfusion and management
- Renal Diseases and Glomerulopathies
- Cancer-related gene regulation
- Chronic Lymphocytic Leukemia Research
- Digital Imaging for Blood Diseases
KPJ Ampang Puteri Specialist Hospital
2016-2025
Hospital Kuala Lumpur
2014-2025
Ministry of Health
2019-2023
Englewood Hospital and Medical Center
2022
National Institutes of Health
2021
Technical University of Munich
2019
John Wiley & Sons (United Kingdom)
2017
University Malaya Medical Centre
2013
Background: Perioperative anemia has been associated with increased risk of red blood cell transfusion and morbidity mortality after surgery. The optimal approach to the diagnosis management perioperative is not fully established. Objective: To develop consensus recommendations for in surgical patients. Methods: An international expert panel reviewed current evidence developed using modified RAND Delphi methodology. Results: recommends that all patients except those undergoing minor...
Hematopoietic stem-cell transplantation-associated thrombotic microangiopathy (HSCT-TMA) is a serious complication with significant mortality and no approved therapy. HSCT-TMA results from endothelial injury, which activates the lectin pathway of complement. Narsoplimab (OMS721), an inhibitor mannan-binding lectin-associated serine protease-2 (MASP-2), was evaluated for safety efficacy in adults HSCT-TMA.In this single-arm open-label pivotal trial (NCT02222545), patients received intravenous...
Introduction Similar to other populations, full blood count reference (FBC) intervals in Malaysia are generally derived from non-Malaysian subjects. However, numerous studies have shown significant differences between and within populations supporting the need for population specific intervals. Methods Two thousand seven hundred twenty five apparently healthy adults comprising all ages, both genders three principal races were recruited through voluntary participation. FBC was performed on...
The burden of dengue continues to increase globally, with an estimated 100 million clinically apparent infections occurring each year. Although most are asymptomatic, patients can present a wide spectrum clinical symptoms ranging from mild febrile illness through severe manifestations bleeding, organ impairment, and hypovolaemic shock due systemic vascular leak syndrome. Clinical diagnosis identification which likely develop disease remain challenging. This study aims improve management...
Abstract Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired hematologic disorder characterized by complement-mediated hemolysis. C5 inhibitors (eculizumab/ravulizumab) control intravascular hemolysis but do not prevent residual extravascular The newly approved complement inhibitor, pegcetacoplan, inhibits C3, upstream of C5, and has the potential to improve PADDOCK PALOMINO clinical trials assessed safety efficacy pegcetacoplan in inhibitor-naïve adults (≥ 18 years) diagnosed with...
Currently, several assays can diagnose acute dengue infection. However, none of these predict the severity disease. Biomarkers that predicts likelihood a patient will develop severe form disease could permit more efficient triage and allows better supportive care for individual in need, especially during outbreaks. We measured 20 plasma markers i.e. IFN-γ, IL-10, granzyme-B, CX3CL1, IP-10, RANTES, CXCL8, CXCL6, VCAM, ICAM, VEGF, HGF, sCD25, IL-18, LBP, sCD14, sCD163, MIF, MCP-1 MIP-1β 141...
We aimed to characterise baseline disease and treatment burden in a large population with haemophilia A/B, both (HAwI/HBwI) without (HA/HB) inhibitors.
Background With its elusive pathogenesis, dengue imposes serious healthcare, economic and social burden on endemic countries. This study describes the clinical immunological parameters of a cohort in Malaysian city, first according to WHO 2009 classification. Methodology Findings longitudinal descriptive was conducted two hospitals where patients aged 14 above with symptoms suggestive were recruited informed consent. Among 504 participants, 9.3% classified as non-dengue, 12.7% without...
Background N8‐ GP (turoctocog alfa pegol) is an extended half‐life glyco PEG ylated recombinant factor VIII ( FVIII ) product developed for the prevention and treatment of bleeds in haemophilia A patients. Aim This a planned interim analysis pathfinder™3, international, open‐label, Phase 3 trial evaluating efficacy safety (including immunogenicity) administered before, during after major surgery severe patients aged ≥12 years. Methods Sixteen who underwent 18 surgical procedures synovectomy,...
Background: Clinical significance of germinal center B-cell (GCB) and non-GCB sub-categorization, expression MYC, BCL2, BCL6, CD5 proteins Epstein Barr virus encoded RNA (EBER) positivity in diffuse large lymphoma (DLBCL) remain controversial. Could these biomarkers accurately identify high risk DLBCL patients? Are BCL2 BCL6 feasible as baseline testing to predict c-Myc, or gene rearrangements? Aims: To investigate prognostic values GCB/non-GCB Double Protein Expression Lymphoma (DPL),...
The evolution of molecular studies in myeloproliferative neoplasms (MPN) has enlightened us the understanding this complex disease consisting polycythaemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF). epidemiology is well described western world but not Asian countries like Malaysia.This retrospective national registry MPN was conducted from year 2009 to 2015 Malaysia.A total 1010 patients were registered over a period 5 years. mean age 54 years with male...
Haemoglobin (Hb) G-Makassar is a rare Hb variant. It presents diagnostic challenge as it imitates sickle (Hb S) in standard electrophoresis and high-performance liquid chromatography assays requiring DNA analysis to confirm diagnosis. Both have point mutations codon 6, exon 1 the β-globin (
Fetal hemoglobin (HbF) is the predominant in red cells during fetal life. Just after birth, level of HbF decreases gradually to <1%, and replaced mainly by adult (HbA) (∼97%). However, higher levels could be associated with HbE/β-thalassemia, a complex thalassemia intermedia diverse clinical severity ranging from mild-to-severe anemia. This study investigates correlation laboratory data HbE/β-thalassemia individuals.
Nonadherence to iron chelation therapy (ICT) remains a long-standing and serious issue in thalassemia, especially resource-constrained developing countries. Barriers facilitators of adherence ICT transfusion-dependent thalassemia (TDT) adult patients Malaysia are not completely understood. This qualitative study explored factors affecting among TDT at public tertiary hospital Malaysia. Data were collected through 21 semistructured in-depth interviews conducted purposively sampled using...