A5014478150- Mosquito-borne diseases and control
- Malaria Research and Control
- Viral Infections and Vectors
- Influenza Virus Research Studies
- Respiratory viral infections research
- vaccines and immunoinformatics approaches
- Virology and Viral Diseases
- HIV Research and Treatment
- Long-Term Effects of COVID-19
- COVID-19 and Mental Health
- Dengue and Mosquito Control Research
- COVID-19 Clinical Research Studies
- Infectious Encephalopathies and Encephalitis
- Plant Virus Research Studies
- Immune Cell Function and Interaction
- Coconut Research and Applications
- Insect symbiosis and bacterial influences
- Autism Spectrum Disorder Research
- Insect-Plant Interactions and Control
- Monoclonal and Polyclonal Antibodies Research
- T-cell and Retrovirus Studies
- RNA Interference and Gene Delivery
- Viral Infections and Immunology Research
- Research on Leishmaniasis Studies
- Tannin, Tannase and Anticancer Activities
Monash University Malaysia
2021-2024
University Malaya Medical Centre
2014
University of Malaya
2014
Oropouche virus (OROV) is an orthobunyavirus (Peribunyaviridae) that has caused recurrent outbreaks in South America and recently expanded into the Caribbean, with various biting midge mosquito species considered vectors. Recent imported cases to Europe North have raised concerns about potential for local transmission non-endemic areas. To assess this risk United Kingdom, we investigated vector competence of Culex pipiens molestus (Cx. molestus), a human-biting common urban environments....
Background With its elusive pathogenesis, dengue imposes serious healthcare, economic and social burden on endemic countries. This study describes the clinical immunological parameters of a cohort in Malaysian city, first according to WHO 2009 classification. Methodology Findings longitudinal descriptive was conducted two hospitals where patients aged 14 above with symptoms suggestive were recruited informed consent. Among 504 participants, 9.3% classified as non-dengue, 12.7% without...
Melanoma incidence and mortality have risen dramatically in recent years. No effective treatment for metastatic melanoma exists; hence currently, an intense effort new drug evaluation is being carried out. In this study, we investigated the effects of a palm oil-derived nanopolymer called Bio-12 against human malignant melanoma. The nanopolymers are lipid esters derived from range fatty acids oil. Our study aims to identify anti-proliferative properties cell line (MeWo) elucidate mode...
<title>Abstract</title> Zika virus (ZIKV) garnered global attention over the past decade as outbreaks of disease were linked to neurological complications. There are currently no antiviral drugs or vaccines with proven efficacy. The identification human proteins targeted by ZIKV is crucial for deciphering host pathways hijacked replicate, evade innate immunity, and induce neuropathogenesis. In our study, Y2H screening 8 identified 85 interacting factors. These factors primarily involved in...
<title>Abstract</title> Chikungunya virus (CHIKV) is a single-stranded RNA belonging to the <italic>Togaviridae</italic> family and Alphavirus genus. It causes chikungunya fever, transmitted by <italic>Aedes</italic> mosquitoes, characterized severe joint pain, rash, headaches, muscle pain lasting days weeks. In some cases, chronic arthritis resembling rheumatoid can develop post-infection. Currently, there's no specific antiviral treatment for CHIKV, with supportive care being main...
The two most clinically important members of the flavivirus genus, Zika virus (ZIKV) and dengue (DENV) pose a significant public health challenge. They cause range diseases in humans, from hemorrhagic to neurological manifestations, leading economic social burden worldwide. Nevertheless, there are no approved antiviral drugs treat these infections. Zafirlukast is an orally available Food Drug Administration (FDA) drug for prophylaxis treatment chronic asthma. It leukotriene receptor...
Every year, influenza virus infections cause significant morbidity and mortality worldwide. They pose a substantial burden of disease, not only in terms health but also economic-wise. Owing to the ability viruses continuously evolve, annual seasonal vaccines are necessary as prophylaxis. However, current against strains have limited effectiveness require yearly reformulation due undergoing antigenic drift or shift. Vaccine mismatches common, conferring suboptimal protection outbreaks, threat...
Zika virus infection has been associated with adverse pregnancy and birth outcomes numerous neurological complications such as microcephaly other congenital abnormalities. When a infects a host cell, it alters host cell protein production interaction network by hijacking competing proteins. The outcome of is determined by complex host-virus interactions. Having insights into the host's responses to viruses would help define targets for therapeutic intervention. Hence, the study aims to...