A5113659929- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- COVID-19 and healthcare impacts
- Cell death mechanisms and regulation
- Drug Transport and Resistance Mechanisms
- Pharmacological Effects and Toxicity Studies
- RNA Interference and Gene Delivery
- Respiratory viral infections research
- Respiratory Support and Mechanisms
- COVID-19 Impact on Reproduction
- Antibiotic Use and Resistance
- Viral Infections and Vectors
- Sepsis Diagnosis and Treatment
- Nosocomial Infections in ICU
- Plant Virus Research Studies
- Bacillus and Francisella bacterial research
- Muscle and Compartmental Disorders
- Genetic Associations and Epidemiology
- Insect-Plant Interactions and Control
- Vagus Nerve Stimulation Research
- PARP inhibition in cancer therapy
- Bacterial Infections and Vaccines
- Liver Disease Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
University of Liverpool
2021-2024
International Severe Acute Respiratory and Emerging Infection Consortium
2023
St Mary's Hospital
2023
Centre for Inflammation Research
2022
University of Edinburgh
2022
The Queen's Medical Research Institute
2022
University of Manchester
2002-2013
Wellcome Centre for Cell-Matrix Research
2010-2013
Salford Royal Hospital
2004-2005
University of Salford
2004
SummaryThe proapoptotic Bcl-2 protein Bax is predominantly found in the cytosol of nonapoptotic cells and commonly thought to translocate mitochondria following an apoptotic stimulus. The current model for activation that BH3 proteins bind cytosolic Bax, initiating mitochondrial targeting outer-membrane permeabilization. Here, we challenge this show constitutively targeted but constantly translocated back cytosol. Using live-cell spinning-disk confocal imaging with a combination FLIP, FRAP,...
Inhibitor of apoptosis (IAPs) proteins are a family that can block in normal cells and have been suggested to cause resistance cancer. Overexpression oncogenic receptor tyrosine kinases is common breast cancer; particular 20% all cases show elevated Her2. Despite clinical success with the use targeted therapies, such as Trastuzumab, only up 35% Her2-positive patients initially respond. We reasoned IAP-mediated might contribute this insensitivity kinase therapy, ErbB antagonists. Here we...
Information on the extent to which xenobiotics interact with P-glycoprotein (PGP) during transit through intestine is crucial in determining influence of PGP oral drug absorption. We have recently described a novel use isolated ileum from PGP-deficient mdr1a(−/−) mice resolve PGP- and non-PGP-dependent efflux provide definitive measure intrinsic permeability without recourse inhibitors (Stephens et al., 2002). The present study uses this approach investigate impact intestinal paclitaxel...
Introduction: Usutu virus (USUV) has been detected annually in the southeast of England since 2020. USUV RNA identified wild birds and mosquito populations, exposure captive to at Zoological Society London (ZSL) also confirmed. Since its first detection London, USUV's distribution expanded across South East, highlighting a need understand transmission dynamics this UK. The primary vectors UK are likely Culex pipiens mosquitoes. Two biotypes have identified, bird-feeding Cx. molestus which...
Oropouche virus (OROV) is an orthobunyavirus (Peribunyaviridae) that has caused recurrent outbreaks in South America and recently expanded into the Caribbean, with various biting midge mosquito species considered vectors. Recent imported cases to Europe North have raised concerns about potential for local transmission non-endemic areas. To assess this risk United Kingdom, we investigated vector competence of Culex pipiens molestus (Cx. molestus), a human-biting common urban environments....
Abstract Background Inhibitors-of-Apoptosis-Proteins (IAPs) are an evolutionarily conserved family of proteins capable regulating several facets apoptosis. IAPs frequently dysregulated in cancer, but their role the regulation apoptosis during developmental processes is not fully understood. Here we examined expression post-natal development mouse mammary gland, which a tissue that exhibits profound induction involution. Results Six out eight mammalian IAP members expressed gland. Notably,...