A5062266967- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- Herpesvirus Infections and Treatments
- HIV, Drug Use, Sexual Risk
- Chromosomal and Genetic Variations
- Bacillus and Francisella bacterial research
- Poxvirus research and outbreaks
- Monoclonal and Polyclonal Antibodies Research
- T-cell and B-cell Immunology
- Evolution and Genetic Dynamics
- Hepatitis C virus research
- Adolescent Sexual and Reproductive Health
- Drug-Induced Adverse Reactions
- Autoimmune Bullous Skin Diseases
- Immune Cell Function and Interaction
- Urticaria and Related Conditions
- Bacteriophages and microbial interactions
- Blood groups and transfusion
- Immunodeficiency and Autoimmune Disorders
- Sex work and related issues
- Syphilis Diagnosis and Treatment
Fundação Oswaldo Cruz
2020-2024
Instituto Evandro Chagas
2019-2022
By October 30, 2022, 76,871 cases of mpox were reported worldwide, with 20,614 in Latin America. This study reports characteristics a case series suspected and confirmed at referral infectious diseases center Rio de Janeiro, Brazil.
HIV-1 infection is characterized by generalized deregulation of the immune system, resulting in increased chronic activation. However, some individuals called HIV controllers (HICs) present spontaneous control viral replication and have a more preserved system. Among HICs, discordant results been observed regarding activation frequency different T cell subsets, including Treg Th17 cells. We evaluated activation, differentiation regulatory profiles two groups HICs—elite (ECs) viremic...
HIV-1 has an antisense gene overlapping env that encodes the ASP protein. functions are still unknown, but it been associated with gp120 in viral envelope and membrane of infected cells, making a potential target for immune response. Despite this, response patterns against poorly described can be influenced by high genetic variability gene. To explore we analyzed 100k sequences from Los Alamos HIV sequence database using phylogenetic, Shannon entropy (Hs), logo tools to study worldwide...
Mostly cisgender men were affected during the 2022 mpox multinational outbreak, with few cases reported in women. This study compares characteristics of individuals diagnosed infection according to gender Rio de Janeiro. We obtained surveillance data notified Janeiro State Health Department (June 12 December 15, 2022). compared women (cisgender or transgender) using chi-squared, Fisher's exact, and Mood's median tests. A total 1306 reported; 1188 (91.0%) men, 108 (8.3%) (87.0% cisgender,...
Human immunodeficiency virus (HIV)-1 infection can activate the expression of human endogenous retroviruses (HERVs), particularly HERV-K (HML-2). HIV controllers (HICs) are rare people living with (PLWHs) who naturally control HIV-1 replication and overexpress some cellular restriction factors that negatively regulate LTR-driven transcription proviruses.
The antibody-mediated prevention (AMP) studies (HVTN 703/HPTN 081 and HVTN 704/HPTN 085) are harmonized phase 2b trials to assess HIV efficacy safety of intravenous infusion anti-gp120 broadly neutralizing antibody VRC01. Antibodies for other indications can elicit infusion-related reactions (IRRs), often requiring premedication limiting their application. We report on AMP study IRRs.From 2016 2018, 2699 HIV-uninfected, at-risk men transgender adults in the Americas Switzerland (704/085)...
HIV controllers (HICs) are a rare group of HIV-1-infected individuals able to naturally control viral replication. Several studies have identified the occurrence dual infections in seropositive leading disease progression. In HICs, however, with divergent outcomes pathogenesis been described. Here, we present case report HIC diagnosed late 1999 who displayed stable CD4+ T cell levels and low plasmatic load across 12 years follow-up. early 2013, patient started an increase load, reaching peak...
Pre-exposure prophylaxis (PrEP) prevents HIV infection among men who have sex with (MSM) and transgender women (TGW) are the groups that presents high incidence risk in Brazil. This cross-sectional secondary analysis describes possible compensation, attitudes, beliefs regarding use of PrEP 723 MSM TGW evaluated Brazil study pre-screening phase. Possible compensation was reported by 31.6% individuals. In multivariate model, factors increased likelihood were: self-referring as white vs. Black...
Elite controllers (EC) are human immunodeficiency virus (HIV)-positive individuals who can maintain low viral loads for extended periods without antiretroviral therapy due to multifactorial and individual characteristics. Most have a small HIV-1 reservoir composed of identical proviral sequences maintained by clonal expansion infected CD4+ T cells. However, some more diverse peripheral blood mononuclear cell (PBMC)-associated with unique sequences.To understand the turnover dynamics...
HIV-1 infection can activate the expression of human endogenous retroviruses (HERVs), particularly HERV-K (HML-2). HIV controllers (HICs) are rare people living with (PLWH) who naturally control replication. The ability HICs to has not been previously addressed. In this study, we measured ERVK-6 RNA in PBMCs (n = 23), antiretroviral (ART)-suppressed subjects 8), and HIV-1-negative (NEG) individuals 10) correlated transcript multiple restriction factors. Our study reveals that from was...
The analysis of the HIV-1 proviral dynamics after superinfection in context both natural and antiretroviral therapy (ART)-mediated suppression could yield unique insights into understanding persistence viral variants that seeded infected cells at different times. In this study, we performed a longitudinal env diversity PBMC-associated HIV DNA quasispecies two controllers (EEC09 VC32) were superinfected with subtype F1 viruses several years primoinfection B viruses. Patient EEC09 started ART...
Background: The AMP studies (HVTN 703/HPTN 081 and HVTN 704/HPTN 085) are two harmonized Phase 2b randomized controlled trials to assess HIV prevention efficacy safety of intravenous (IV) infusion anti-gp120 broadly neutralizing monoclonal antibody (mAb) VRC01. MAbs for other indications elicit significant rates infusion-related reactions (IRRs), often requiring pre-medication sometimes limiting their application. We report on IRRs observed in the studies. Methods: From 2016-2018, 2,699...