A5075934187- Neonatal Health and Biochemistry
- Malaria Research and Control
- Hemoglobinopathies and Related Disorders
- Mosquito-borne diseases and control
- COVID-19 Clinical Research Studies
- Venomous Animal Envenomation and Studies
- Rabies epidemiology and control
- Long-Term Effects of COVID-19
- Methemoglobinemia and Tumor Lysis Syndrome
- SARS-CoV-2 and COVID-19 Research
- Healthcare and Venom Research
- Infectious Encephalopathies and Encephalitis
- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Respiratory Support and Mechanisms
- COVID-19 epidemiological studies
- Drug-Induced Ocular Toxicity
- Marine Invertebrate Physiology and Ecology
- Drug-Induced Hepatotoxicity and Protection
- Viral Infections and Vectors
- Research on Leishmaniasis Studies
- Global Public Health Policies and Epidemiology
- Vitamin C and Antioxidants Research
- Parasitic Diseases Research and Treatment
- Adrenal Hormones and Disorders
Universidade do Estado do Amazonas
2018-2025
Fundação de Medicina Tropical
2018-2025
Escola Superior de Ciências da Saúde
2018-2024
Universidade Federal do Amazonas
2018-2022
Universidade Federal de Pernambuco
2021
Universidade de Pernambuco
2021
<h3>Importance</h3> There is no specific antiviral therapy recommended for coronavirus disease 2019 (COVID-19). In vitro studies indicate that the effect of chloroquine diphosphate (CQ) requires a high concentration drug. <h3>Objective</h3> To evaluate safety and efficacy 2 CQ dosages in patients with severe COVID-19. <h3>Design, Setting, Participants</h3> This parallel, double-masked, randomized, phase IIb clinical trial 81 adult who were hospitalized acute respiratory syndrome (SARS-CoV-2)...
Steroid use for coronavirus disease 2019 (COVID-19) is based on the possible role of these drugs in mitigating inflammatory response, mainly lungs, triggered by severe acute respiratory syndrome 2 (SARS-CoV-2). This study aimed to evaluate efficacy methylprednisolone (MP) among hospitalized patients with suspected COVID-19.A parallel, double-blind, placebo-controlled, randomized, Phase IIb clinical trial was performed aged ≥18 years clinical, epidemiological, and/or radiological COVID-19 at...
The outbreak of new coronavirus disease 2019 (COVID-19) reported for the first time in Wuhan, China late December have rapidly spread to other countries and it was declared on January 30, 2020 as a public health emergency international concern (PHEIC) by World Health Organization. Before COVID-19 cases were Brazil, several measures been implemented including adjustment legal framework carry out isolation quarantine. As increased significantly, measures, mainly reduce mortality severe cases,...
Summary Background There is no specific antiviral therapy recommended for the disease caused by SARS-CoV-2 (COVID-19). Recent publications have drawn attention to possible benefit of chloroquine (CQ). Our study aimed comprehensively evaluate safety and efficacy two different CQ dosages in patients with established severe COVID-19. Methods We performed a parallel, double-blinded, randomized, phase IIb clinical trial, aiming assess as adjunctive hospitalized SARS Manaus, Brazilian Amazon....
The new Coronavirus, called SARS-CoV-2, whose first cases emerged in Wuhan, China late December, 2019 and quickly spread to other countries, was declared on January 30, 2020 a public health emergency of international concern by the World Health Organization regional office for Europe. Even before COVID-19 were identified Brazil, country had articulated several measures ranging from creation ordinances laws, isolation quarantine. However, number has increased significantly, requiring...
Although high mortality has been reported in many COVID-19 studies, very limited postmortem information from complete autopsies is available. We report the findings adrenal glands 28 with confirmed SARS-CoV-2 infection. Microscopic lesions were identified 12/28 patients (46%). Seven cases showed necrosis, generally ischemic; four cortical lipid degeneration; two hemorrhage; and one unspecific focal adrenalitis. Vascular thrombosis patient inflammation association other three observed. No...
BackgroundPrevention of Plasmodium vivax malaria recurrence is essential for elimination in Brazil. We evaluated the real-world effectiveness an updated treatment algorithm P radical cure Brazilian Amazon.MethodsIn this non-interventional observational study, we used retrospective data from implementation a at 43 health facilities Manaus and Porto Velho, The consisted chloroquine (25 mg/kg over 3 days) point-of-care quantitative glucose-6-phosphate dehydrogenase (G6PD) testing followed by...
We present postmortem evidence of invasive pulmonary aspergillosis (IPA) in a patient with severe COVID-19. Autopsies COVID-19 confirmed cases were performed. The died despite antimicrobials, mechanical ventilation, and vasopressor support. Histopathology peripheral blood galactomannan antigen testing IPA. Aspergillus penicillioides infection was by nucleotide sequencing BLAST analysis. Further reports are needed to assess the occurrence frequency IPA SARS-CoV-2 infections, how they interact...
Primaquine (PQ) kills Plasmodium vivax hypnozoites but can cause severe hemolysis in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency. We conducted two systematic reviews. The first used data from clinical trials to determine the variety of definitions and frequency hematological serious adverse events (SAEs) related PQ treatment malaria. second prospective studies case reports describe presentation, management, outcome PQ-associated necessitating hospitalization. In review,...
Acute Kidney Injury (AKI) is the main systemic complication and cause of death in viperid envenomation. Although there are hypotheses for development AKI, mechanisms involved still not established. The aim this study was to evaluate clinical-laboratorial-epidemiological factors associated with AKI victims Bothrops sp This an observational carried out at Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. defined according guidelines Network (AKIN). Among 186 patients evaluated, observed...
Despite glucose-6-phosphate dehydrogenase (G6PD) deficiency prevalence of 5% in the Amazon, primaquine is administered without G6PD screening. This an important cause hospitalization among Plasmodium vivax-infected individuals, leading to life-threatening anemia and acute renal failure across endemic areas. In Manaus, frequency primaquine-induced hemolysis was 85.2 cases per 100 000 users.
Bothrops snakebites usually present systemic bleeding, and the clinical–epidemiological laboratorial factors associated with development of this manifestation are not well established. In study, we assessed prevalence bleeding reported at Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, in Manaus, Amazonas State, Brazil, bleeding. This is an observational, cross-sectional study carried out between August, 2013 July, 2016. Patients who developed on admission or during hospitalization...
To analyse the temporal and spatial distribution as well environmental socioeconomic factors associated with cutaneous leishmaniasis incidence in state of Amazonas, Brazil from 2007 to 2015.Spatial was evaluated sequential thematic maps mean rates disease. A negative binomial regression analysis performed evaluate association studied rate ACL.The average proportion deforestation negatively municipalities (β = -2.178; P 0.019; 95%CI -3.996, -0.361), health system performance index...
Abstract Background Since the novel coronavirus disease outbreak, over 179.7 million people have been infected by SARS-CoV-2 worldwide, including population living in dengue-endemic regions, particularly Latin America and Southeast Asia, raising concern about impact of possible co-infections. Methods Thirteen SARS-CoV-2/DENV co-infection cases reported Midwestern Brazil between April September 2020 are described. Information was gathered from hospital medical records regarding most relevant...
Abstract Background Daily primaquine-induced hemolysis is a common cause of complications during Plasmodium vivax malaria treatment in individuals with glucose 6-phosphate dehydrogenase deficiency (G6PDd). Alternative regimens balancing safety and efficacy are needed. Methods G6PDd participants P. from two sites Brazilian Amazon between 2018 2022 were randomly allocated to three study arms, which received chloroquine (CQ) day 1 3 plus: (arm-1) seven-day course primaquine (PQ) (0.5mg/kg/day),...
Difficulties associated with the assessment of glucose-6-phosphate dehydrogenase deficiency (G6PDd), particularly in remote areas, hinders safe use 8-aminoquinolines such as primaquine (PQ) and tafenoquine against Plasmodium vivax malaria due to risk haemolysis.This cross-sectional study was conducted 41 malaria-endemic municipalities six states Brazilian Amazon, between 2014 2018. Male individuals were screened for G6PDd using qualitative Fluorescent Spot Test fingerpick-collected whole...
Background Currently, antivenoms are the only specific treatment available for snakebite envenoming. In Brazil, over 30% of patients cannot access antivenom within its critical care window. Researchers have therefore proposed decentralizing to community health centers decrease time-to-care and improve morbidity mortality. there is no evidence-based method evaluate capacity units treatment, nor what absolute minimum supplies staff necessary safe effective administration clinical management....
Snake envenomation is a major public health problem in Brazil. Systemic complications that may arise from snakebites are mainly related to coagulopathy. The Lee–White clotting time (LWCT) simple and inexpensive test available even remote facilities. However, the diagnostic value of such needs be evaluated accurately diagnose coagulopathy clinical practice. This study aimed assess reliability LWCT performed hospital routine venom-induced We studied 186 patients admitted at Tropical Medicine...
Glucose-6-phosphate dehydrogenase (G6PD) deficiency testing is not routinely performed before primaquine treatment in most
Background: The use of corticosteroids may help control the cytokine storm occurring in acute respiratory failure due to severe form COVID-19. We evaluated postacute effect used during phase, such as impairment pulmonary function parameters, on day 120 (D120)-follow-up, participants who survived over 28 days. Methods: This is a parallel, double-blind, randomized, placebo-controlled phase IIb clinical trial carried out between April 18 and October 9, 2020, conducted hospitalized patients with...
Abstract Background Relapses in vivax malaria have posed great challenges for control, and they also account a proportion of reported cases. Knowing the real effectiveness 7-day primaquine (PQ) scheme is crucial order to evaluate not only cost-effectiveness implementing new anti-hypnozoite drugs, but how health education strategies can guarantee better compliance be reinforced. This study aimed effect daily treatment with chloroquine PQ supervised by workers versus prescription without...
Background As quantitative glucose 6-phosphate dehydrogenase deficiency (G6PDd) screening tools are evaluated in operational studies, questions remain as to whether they cost-effective. Here, a cost-effectiveness analysis (CEA) was performed estimate the Incremental Cost-effectiveness Ratio (ICER) of introduction test detect G6PDd among P . vivax carriers two municipalities Brazilian Amazon. Methodology/Principal findings This use Standard G6PD malaria treatment units Using perspective...