A5041768133- Healthcare Systems and Practices
- Venous Thromboembolism Diagnosis and Management
- Health, Medicine and Society
- Gout, Hyperuricemia, Uric Acid
- Atrial Fibrillation Management and Outcomes
- COVID-19 Clinical Research Studies
- Acute Myocardial Infarction Research
- Family and Patient Care in Intensive Care Units
- Clinical practice guidelines implementation
- Respiratory Support and Mechanisms
- Emergency and Acute Care Studies
- Heart Failure Treatment and Management
- Potassium and Related Disorders
- Innovations in Medical Education
- Intensive Care Unit Cognitive Disorders
- Cardiac Arrest and Resuscitation
- COVID-19 and healthcare impacts
- Historical Studies and Socio-cultural Analysis
- Otolaryngology and Infectious Diseases
- Pharmaceutical Practices and Patient Outcomes
- Thyroid Disorders and Treatments
- Case Reports on Hematomas
- Clostridium difficile and Clostridium perfringens research
- Ultrasound in Clinical Applications
- Sepsis Diagnosis and Treatment
University Hospital of Geneva
2018-2024
University of Geneva
2024
Geneva College
2020-2024
Hôpital Beau-Séjour
2023
Institution Genevoise de Maintien à Domicile
2017-2020
### What you need to know What is the best way use oxygen therapy for patients with an acute medical illness? A systematic review published in Lancet April 2018 found that supplemental inpatients normal saturation increases mortality.1 Its authors concluded should be administered conservatively, but they did not make specific recommendations on how do it. An international expert panel used inform this guideline. It aims promptly and transparently translate potentially practice-changing...
Abstract Clinical question What are the benefits and harms of thyroid hormones for adults with subclinical hypothyroidism (SCH)? This guideline was triggered by a recent systematic review randomised controlled trials, which could alter practice. Current practice guidelines tend to recommend stimulating hormone (TSH) levels >10 mIU/L people lower TSH values who young, symptomatic, or have specific indications prescribing. Recommendation The panel issues strong recommendation against in SCH...
Abstract Background Serological assays detecting anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies are being widely deployed in studies and clinical practice. However, the duration effectiveness of protection conferred by immune response remains to be assessed population-based samples. To estimate incidence newly acquired SARS-CoV-2 infections seropositive individuals as compared seronegative controls, we conducted a retrospective longitudinal matched study....
Importance Thromboprophylaxis is recommended for medical inpatients at risk of venous thromboembolism (VTE). Risk assessment models (RAMs) have been developed to stratify VTE risk, but a prospective head-to-head comparison validated RAMs lacking. Objectives To prospectively validate an easy-to-use RAM, the simplified Geneva score, and compare its prognostic performance with previously RAMs. Design, Setting, Participants This cohort study was conducted from June 18, 2020, January 4, 2022,...
### What you need to know Is the needle tip configuration important when performing a lumbar puncture for any indication? A systematic review published in Lancet December 2017 suggests that it is. The found using atraumatic (pencil-point) needles instead of conventional reduced risk post-dural-puncture headache and return hospital additional pain control.1 This guideline recommendation aims promptly transparently translate this evidence clinical recommendation, following standards GRADE...
Abstract Clinical question What is the impact of sodium-glucose cotransporter-2 (SGLT-2) inhibitors on survival and cardiovascular kidney outcomes for adults living with chronic disease (CKD)? Current practice Few therapies slow progression improve long term prognosis CKD. SGLT-2 have demonstrated benefits in CKD without type 2 diabetes. Existing guidance does not account totality current best evidence provide fully stratified treatment effects recommendations across all risk groups based...
Abstract Importance Serological assays detecting specific IgG antibodies generated against the Spike protein following Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection are being widely deployed in research studies and clinical practice. However, duration effectiveness of protection conferred by immune response future remains to be assessed a large population. Objective To estimate incidence newly acquired SARS-CoV-2 infections seropositive individuals from...
<b><i>Background:</i></b> The COVID-19 pandemic has led to shortage of intensive care unit (ICU) capacity. We developed a triage strategy including noninvasive respiratory support and admission the intermediate (IMCU). ICU was restricted patients requiring invasive ventilation. <b><i>Objectives:</i></b> aim this study is describe characteristics outcomes admitted IMCU. <b><i>Method:</i></b> Retrospective cohort...
BACKGROUND: Admission to the hospital is a major risk factor for development of venous thromboembolism (VTE). Whether thromboprophylaxis with low-molecular-weight heparin prevents symptomatic VTE in medically ill, hospitalized older adults remains debated. METHODS: In prospective, randomized, placebo-controlled, double-blind, multicenter trial, (>70 years age) acute medical conditions were randomly assigned receive 40 mg day (enoxaparin) or placebo 6 14 days. The primary efficacy outcome was...
Through the analysis of notable studies from 2024, this article offers an overview key advances in internal medicine with a selection essential themes. The topics covered include common conditions such as cardiovascular diseases, pulmonary disorders, antibiotic use, and fever unknown origin. This provides practical summary to help clinicians stay informed about latest diagnostic therapeutic developments.
Thromboprophylaxis (TPX) prescription is recommended in medical inpatients categorized as high risk of venous thromboembolism (VTE) by validated assessment models (RAMs), but how various RAMs differ categorizing patients groups, and whether the choice RAM influences estimates appropriate TPX use unknown.To determine proportion or low according to RAMs, investigate appropriateness prescription.This a prospective cohort study acutely ill from 3 Swiss university hospitals. Participants were VTE...
Objective To develop an automatic gout register from electronic health records (EHRs) data. Methods We analysed the EHR of all patients >18 years old a tertiary academic hospital (2013–2022) based on six criteria: International Classification Diseases 10 diagnosis, urate-lowering therapy prescription, monosodium urate crystals in joint aspiration and gout-related terms problem lists, clinical or imaging reports. assessed positive negative predictive value (PPV NPV) query by chart reviews....
Diagnosing pneumonia in emergency departments is challenging because the accuracy of symptoms, signs and laboratory tests limited. As a confirmation test, chest X-ray has significant limitations outperformed by CT-scan. However, obtaining CT-scan all cases suspected drawbacks. We used cohort 200 consecutive elderly patients admitted to hospital for build simple prediction score, which was determine indication performing The reference diagnosis adjudicated experts considering available data,...
Hospital-acquired venous thromboembolism (VTE) is one of the leading preventable causes in-hospital mortality. However, its risk assessment in medically ill inpatients complicated due to patients' heterogeneity and complexity currently available models (RAMs). The simplified Geneva score provides simplicity but has not yet been prospectively validated. Immobility an important predictor for VTE RAMs, definition inconsistent based on subjective by nurses or physicians. In this study, we aim...
Pharmacological thromboprophylaxis slightly increases bleeding risk. The only risk assessment model to predict in medical inpatients, the IMPROVE score, has never been validated using prospectively collected outcome data.
Abstract Background Dapagliflozin, a sodium‐glucose cotransporter 2 inhibitor, was shown in the DAPA‐HF study to reduce risk of worsening heart failure or death symptomatic patients with left ejection fraction <40%, irrespective diabetes. The aim this evaluate eligibility status for dapagliflozin non‐selected hospitalized acute decompensated (ADHF), as well prognostic implications status. Materials and methods Analysis 815 recruited prospective cohort at University Hospitals Geneva,...
Burnout and low job satisfaction are increasing among the General Internal Medicine (GIM) workforce. Whether part-time compared to full-time clinical employment is associated with better wellbeing, health hospitalists remains unclear.We conducted an anonymized cross-sectional survey board-certified general internists (i.e. hospitalists) from GIM departments in 14 Swiss hospitals. Part-time work was defined as of <100% a clinician. The primary outcome well-being, measured by extended...
Two successive COVID-19 flares occurred in Switzerland spring and autumn 2020. During these periods, therapeutic strategies have been constantly adapted based on emerging evidence. We aimed to describe adaptations evaluate their association with patient outcomes a cohort of patients admitted the hospital. Consecutive Geneva Hospitals during two were included. Characteristics periods compared as well management including medications, respiratory support admission ICU intermediate care unit...
In this selective overview of articles, we describe new concepts, therapeutic measures and pharmacological agents that may modify current practice in clinical internal medicine. Novelties for the management cardiovascular disease, such as heart failure, hypoxemic respiratory nosocomial pneumonia certain allergies are discussed.
Pleural space infections occur in approximately 10% of patients hospitalized for pneumonia and their incidence is increasing with an aging population. Pulmonary ultrasound a good bedside diagnostic tool able to reduce complications associated thoracocentesis drainage. The RAPID score being increasingly validated as predictor mortality but has not yet been proven useful guide the treatment strategy needs incorporation into prospective studies. Awaiting studies on outcome prediction comparison...
Abstract Objective To develop an automatic gout register to improve management. Methods We analysed the electronic health records (EHR) of all patients >18 years old from a tertiary academic hospital (2013-2022) based on six criteria: International Classification Diseases 10 (ICD-10) diagnosis, urate-lowering therapy (ULT) prescription, uric acid crystal in joint aspiration and gout-related terms problem lists, clinical or imaging reports. assessed positive negative predictive value (PPV...