Ángela Rojas
A5031957769- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Liver Disease and Transplantation
- Diet, Metabolism, and Disease
- Cancer, Hypoxia, and Metabolism
- Hepatitis B Virus Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Diseases and Immunity
- MicroRNA in disease regulation
- Endoplasmic Reticulum Stress and Disease
- Extracellular vesicles in disease
- Systemic Lupus Erythematosus Research
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Diet and metabolism studies
- Urbanism, Landscape, and Tourism Studies
- Metabolism, Diabetes, and Cancer
- Metabolism and Genetic Disorders
- Archaeology and Cultural Heritage
- Alcohol Consumption and Health Effects
- Circular RNAs in diseases
- Drug-Induced Hepatotoxicity and Protection
- Peroxisome Proliferator-Activated Receptors
- Lipid metabolism and disorders
Instituto de Biomedicina de Sevilla
2016-2025
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2016-2025
Hospital Universitario Virgen del Rocío
2016-2025
Universidad de Sevilla
2009-2025
Instituto de Salud Carlos III
2021-2025
Centro Medico Nacional Siglo XXI
2025
Centre for Biomedical Network Research on Rare Diseases
2022-2025
Universidad de Guadalajara
2024
Hospital Universitario Virgen Macarena
2016-2019
University of Geneva
2019
Prospective drug-induced liver injury (DILI) registries are important sources of information on idiosyncratic DILI. We aimed to present a comprehensive analysis 843 patients with DILI enrolled into the Spanish Registry over 20-year time period.Cases were identified, diagnosed and followed prospectively. Clinical features, drug outcome data collected.A total patients, mean age 54 years (48% females), up 2018. Hepatocellular was associated younger (adjusted odds ratio [aOR] per year 0.983; 95%...
Cirrhosis likely shares common pathophysiological pathways despite arising from a variety of liver diseases. A recent GWAS identified rs641738, polymorphism in the MBOAT7 locus, as being associated with development alcoholic cirrhosis. Here we explore role this variant on inflammation and fibrosis two cohorts patients chronic hepatitis C. In 2,051 patients, rs641738 severe hepatic increased risk fibrosis, well fast progression. At functional level, transcript protein levels blood, serum...
Abstract Quercetin is a natural flavonoid, which has been shown to have anti hepatitis C virus (HCV) properties. However, the exact mechanisms whereby quercetin impacts HCV life cycle are not fully understood. We assessed effect of on different steps in Huh-7.5 cells and primary human hepatocytes (PHH) infected with HCVcc. In both cell types, significantly decreased i) viral genome replication; ii) production infectious particles iii) specific infectivity newly produced (by 85% 92%, Huh7.5...
The main aim was to evaluate changes in urea cycle enzymes NAFLD patients and two preclinical animal models mimicking this entity. Seventeen liver specimens from were included for immunohistochemistry gene expression analyses. Three-hundred-and-eighty-two biopsy-proven genotyped rs1047891, a functional variant located carbamoyl phosphate synthetase-1 (CPS1) gene. Two employed analyse CPS1 by immunohistochemistry, choline deficient high-fat diet model (CDA-HFD) high fat LDLr knockout (LDLr...
We aimed to assess the role of FGF21 in metabolic dysfunction-associated steatotic liver disease (MASLD) at a multi-scale level.
To investigate the influence of metformin use on liver dysfunction and hepatic encephalopathy in a retrospective cohort diabetic cirrhotic patients. analyze impact glutaminase activity ammonia production vitro.
Abstract Background and Aims Liver cancer stem cells (CSCs) could be involved in the carcinogenesis, recurrence, metastasis chemoresistance of hepatocellular carcinoma (HCC). The aim this study was to explore role lncRNA‐ H19 as a biomarker for liver cancer. Methods LncRNA‐ expression levels functional assays were conducted EpCAM + CD133 CSCs C57BL/6J mice fed with high‐fat high‐cholesterol carbohydrate (HFHCC) or standard diet 52 weeks. tissue plasma samples from patients cirrhosis, without...
Hepatitis C virus (HCV) infection has been related to increased risk of development hepatocellular carcinoma (HCC) while metformin (M) and statins treatment seemed protect against HCC development. In this work, we aim identify the mechanisms by which simvastatin (S) could from liver cancer. Huh7.5 cells were infected with HCV particles treated M+S. Human primary hepatocytes Treatment both drugs inhibited cell growth infection. non-infected S translational controlled tumor protein (TCTP)...
Metabolic-associated fatty liver disease (MAFLD) has risen as one of the leading etiologies for hepatocellular carcinoma (HCC). Oncogenes have been suggested to be responsible high risk MAFLD-related HCC. We analyzed impact proto-oncogene c-MYC in development human and murine MAFLD MAFLD-associated HCC.alb-myctg mice were studied at baseline conditions after administration Western diet (WD) comparison WT littermates. expression was biopsies patients with HCC by immunohistochemistry.Mild...
miR-21-5p is a potent oncogenic microRNA targeting many key tumour suppressors including phosphatase and tensin homolog (PTEN). We recently identified PTEN as factor modulated by hepatitis C virus (HCV) to promote virion egress. In hepatocytes, expression of HCV-3a core protein was sufficient downregulate trigger lipid droplet accumulation. Here, we investigated whether HCV controls through miR-21-5p-dependent mechanisms steatosis in hepatocytes life cycle.MiR-21-5p HCV-infected patients...
INTRODUCTION: Hepatitis C virus (HCV) infection has been related to increased cardiovascular (CV) risk. The aim of this study was analyze the impact sustained virological response (SVR) on endothelial dysfunction and subclinical atherosclerosis in patients with hepatitis treated direct-acting antiviral agents. METHODS: A total 114 were prospectively recruited underwent CV risk assessment including (i) determined through laser Doppler flowmetry (ii) atherosclerosis, elucidated by...
Abstract Background & Aims Information about the impact of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) in patients with liver cancer is lacking. This study characterizes outcomes and mortality risk this population. Methods Multicentre retrospective, cross‐sectional, international SARS‐CoV‐2 infection registered between February December 2020. Clinical data at diagnosis were registered. Results Two hundred fifty from 38 centres included, 218 hepatocellular carcinoma (HCC)...
The global prevalence of non-alcoholic fatty liver disease (NAFLD) is nearly 25% and increasing rapidly. spectrum damage in NAFLD ranges from simple steatosis to steatohepatitis, characterised by the presence lobular inflammation hepatocyte ballooning degeneration, with or without fibrosis, which can further develop into cirrhosis hepatocellular carcinoma. Not only a progressive disease, but numerous pieces evidence also point extrahepatic consequences. Accumulating suggests that patients...
Metabolic liver disease is the fastest-rising cause of hepatocellular carcinoma (HCC), but underlying molecular processes that drive HCC development in setting metabolic perturbations are unclear. We investigated role aberrant DNA methylation a multicenter international study. used case-control design, frequency-matched on age, sex, and study site. Genome-wide profiling peripheral blood leukocyte was performed using 850k EPIC array. The sample split 80% 20% for training validation. Cell type...
Summary Hepatitis C virus ( HCV ) interacts with lipid receptors to enter the cell, circulates as lipoviroparticle and is secreted VLDL . We aimed investigate role of rs12979860 polymorphism in IL28B gene 143 chronic hepatitis genotype 1, 144 infected 3, 90 4 413 noninfected individuals on profile test impact infection an vitro model biosynthesis‐related expression was analysed using real‐time PCR coupled F luorescence R esonance E nergy T ransfer FRET ). H uh7.5 (rs12979860 CT) uh7...