A5028542640- Liver Disease Diagnosis and Treatment
- Fatty Acid Research and Health
- Cholesterol and Lipid Metabolism
- Drug-Induced Hepatotoxicity and Protection
- Liver physiology and pathology
- Antioxidant Activity and Oxidative Stress
- Cancer, Lipids, and Metabolism
- Metabolism and Genetic Disorders
- Pancreatic function and diabetes
- Nutritional Studies and Diet
- Diet, Metabolism, and Disease
- Cardiovascular Disease and Adiposity
- Lipoproteins and Cardiovascular Health
- Phagocytosis and Immune Regulation
- Medicinal Plants and Bioactive Compounds
Centro Andaluz de Biología Molecular y Medicina Regenerativa
2016-2022
Universidad de Sevilla
2021-2022
Universidad Pablo de Olavide
2018-2021
The main aim was to evaluate changes in urea cycle enzymes NAFLD patients and two preclinical animal models mimicking this entity. Seventeen liver specimens from were included for immunohistochemistry gene expression analyses. Three-hundred-and-eighty-two biopsy-proven genotyped rs1047891, a functional variant located carbamoyl phosphate synthetase-1 (CPS1) gene. Two employed analyse CPS1 by immunohistochemistry, choline deficient high-fat diet model (CDA-HFD) high fat LDLr knockout (LDLr...
Scope We evaluated the protective effect of extra virgin olive oil (EVOO) in high‐fat diets (HFDs) on inflammatory response and liver damage a nonalcoholic fatty disease (NAFLD) mouse model. Methods results C57BL/6J mice were fed standard diet or lard‐based HFD (HFD‐L) for 12 wk to develop NAFLD. HFD‐fed then divided into four groups 24 with following: HFD‐L, HFD‐EVOO, based phenolics‐rich EVOO, reversion (standard diet). HFD‐L‐induced metabolic disorders alleviated by replacement lard EVOO....
Scope The present study investigates the effect of olive oils with different phenolic content in high‐fat diets (HFDs) on hypertrophy and inflammation adipose tissue associated atherosclerosis, context obesity. Methods results Ldlr −/−.Leiden mice were fed three HFDs for 32 weeks compared standard low‐fat diet (LFD). fats provided lard (HFD‐L), extra‐virgin oil (EVOO; 79 mg kg –1 compounds, HFD‐EVOO), or EVOO rich compounds (OL, 444 HFD‐OL). All HFD‐fed became obese, but only HFD‐L–induced...
Abstract Dietary fatty acids play a role in the pathogenesis of obesity-associated non-alcoholic liver disease (NAFLD), which is associated with insulin resistance (IR). Fatty acid composition critical for IR and subsequent NAFLD development. Extra-virgin olive oil (EVOO) main source monounsaturated (MUFA) Mediterranean diets. This study examined whether EVOO-containing high fat diets may prevent diet-induced using Ldlr−/−. Leiden mice. In female mice, effects following (HFDs) were examined:...
Liver fibrosis can be caused by non-alcoholic steatohepatitis (NASH), among other conditions. We performed a study to analyze the effects of nontoxic, water-soluble extract edible mushroom Agaricus bisporus (AB) as potential inhibitor progression in vitro using human hepatic stellate cell (LX2) cultures and vivo LDLR-/- mice. Treatment LX2 cells with AB reduced levels fibrotic oxidative-related markers increased GATA4 expression. In mice high-fat diet (HFD)-induced liver inflammation,...