A5054867793- Liver Disease Diagnosis and Treatment
- Pancreatic function and diabetes
- Metabolism, Diabetes, and Cancer
- Fatty Acid Research and Health
- Diabetes and associated disorders
- Phytochemicals and Antioxidant Activities
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Microbial Metabolites in Food Biotechnology
- Peptidase Inhibition and Analysis
- Cancer, Lipids, and Metabolism
- Diet, Metabolism, and Disease
- Lipid metabolism and biosynthesis
- Polysaccharides and Plant Cell Walls
- Food Quality and Safety Studies
- Nutritional Studies and Diet
- Cytokine Signaling Pathways and Interactions
- Alcohol Consumption and Health Effects
- Cancer, Hypoxia, and Metabolism
- Obstructive Sleep Apnea Research
- Medical Imaging and Pathology Studies
- Metabolism and Genetic Disorders
- Sleep and Work-Related Fatigue
- Genetic and Kidney Cyst Diseases
- RNA regulation and disease
Centro Andaluz de Biología Molecular y Medicina Regenerativa
2021-2024
Universidad Pablo de Olavide
2021-2024
Universidad de Sevilla
2021-2024
Instituto de Salud Carlos III
2022-2024
Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas
2021-2024
Medical Research Network
2022
Junta de Andalucía
2021-2022
Development Fund
2021
Background and Aims: Alcohol-associated liver disease (ALD) accounts for 70% of liver-related deaths in Europe, with no effective approved therapies. Although mitochondrial dysfunction is one the earliest manifestations alcohol-induced injury, restoring activity remains a problematic strategy due to oxidative stress. Here, we identify methylation-controlled J protein (MCJ) as mediator ALD progression hypothesize that targeting MCJ may help recovering fitness without collateral damage....
Abstract Dietary fatty acids play a role in the pathogenesis of obesity-associated non-alcoholic liver disease (NAFLD), which is associated with insulin resistance (IR). Fatty acid composition critical for IR and subsequent NAFLD development. Extra-virgin olive oil (EVOO) main source monounsaturated (MUFA) Mediterranean diets. This study examined whether EVOO-containing high fat diets may prevent diet-induced using Ldlr−/−. Leiden mice. In female mice, effects following (HFDs) were examined:...
LRH-1/NR5A2 is implicated in islet morphogenesis postnatally, and its activation using the agonist BL001 protects islets against apoptosis, reverting hyperglycemia mouse models of Type 1 Diabetes Mellitus. Islet transcriptome profiling revealed that expression PTGS2/COX2 increased by BL001. Herein, we sought to define role LRH-1 postnatal chart mode action conferring beta cell protection. ablation within developing cells impeded proliferation, correlating with growth retardation, weight...
Persimmon fruit processing-derived waste and by-products, such as peels pomace, are important sources of dietary fiber phytochemicals. Revalorizing these by-products could help promote circular nutrition agricultural sustainability while tackling deficiencies chronic diseases. In this study, fiber-rich fractions were prepared from the Sharoni Brilliant Red persimmon varieties. These quantified for their phenolic composition assessed ability to growth beneficial human colonic Firmicutes...
The aim of this study was to compare dietary habits, sleep and injury incidence between shift days off among Spanish firefighters.24-Hour recalls, questionnaires on both were collected from 28 Sevillian professional firefighter, as well anthropometric measurements a physical activity questionnaire.Firefighters consumed 433 more kilocalories (P < 0.001), 2.4% 3.1% fat monounsaturated fatty acids, respectively 0.05), had 3.7 times greater chance being injured slept 2 hours 18 minutes less...
ABSTRACT We have previously described a role of LRH-1/NR5A2 in islet morphogenesis during postnatal development and reported that the treatment with BL001, an agonist LRH-1/NR5A2, protects islets against-stress induced apoptosis reverts hyperglycemia 3 mouse models Type 1 Diabetes Mellitus (T1DM). Islet transcriptome profiling revealed most differentially expressed genes after BL001 are involved immunomodulation, among them, increase PTGS2/COX2 expression. Herein, we dissected cellular...