A5091128561- Liver Disease Diagnosis and Treatment
- Liver Diseases and Immunity
- Liver Disease and Transplantation
- Hepatitis C virus research
- Gallbladder and Bile Duct Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Drug-Induced Hepatotoxicity and Protection
- Hepatitis Viruses Studies and Epidemiology
- Pancreatitis Pathology and Treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- Hepatitis B Virus Studies
- Colorectal Cancer Screening and Detection
- Celiac Disease Research and Management
- Genetic factors in colorectal cancer
- Abdominal vascular conditions and treatments
- Systemic Lupus Erythematosus Research
- Muscle and Compartmental Disorders
- Vascular anomalies and interventions
- Poisoning and overdose treatments
- Diagnosis and treatment of tuberculosis
- Congenital Anomalies and Fetal Surgery
- IgG4-Related and Inflammatory Diseases
- Immunodeficiency and Autoimmune Disorders
- Alcoholism and Thiamine Deficiency
- Pharmaceutical Practices and Patient Outcomes
Hospital Universitario 12 De Octubre
2009-2025
Research Institute Hospital 12 de Octubre
2010-2023
Hospital Universitario Fundación Alcorcón
2023
Servicio Nacional de Hidrología y Meteorología
2021
Universidad Complutense de Madrid
2007-2010
Hospital Universitario de La Princesa
2003-2006
Universidad Autónoma de Madrid
2006
Instituto de Salud Carlos III
2006
Hospital Universitario de Guadalajara
2006
Summary Background Non‐alcoholic fatty liver disease (NAFLD) encompasses a wide spectrum of injury. Currently, there are no proven effective therapies available. Atorvastatin is new 3‐hydroxy‐3‐metylglutaryl coenzyme A reductase inhibitor that reduces lipid serum levels. Aim To evaluate the effectiveness and safety atorvastatin in dyslipemid, non‐alcoholic patients. Patients methods We prospectively enrolled 25 patients with NAFLD; 22 them completed study. Body mass index, lipids, function...
The initial approach to autoimmune hepatitis is based on the use of immunosuppressants and corticosteroids. first-line immunosuppression options include azathioprine or mycophenolate mofetil. Long-term predisposes patients development neoplastic diseases. In this case, chronic AIH treatment with mofetil was associated onset primary cerebral lymphoma, which treated methotrexate rituximab. Rituximab an interesting therapy for AIH, in it able treat both conditions.
Summary Background Transient elastography is a novel and non‐invasive technique for the evaluation of fibrosis in chronic liver disease. Few studies that exist value efficacy transient elastography, mainly hepatitis C virus‐infected patients. Aim To evaluate effectiveness, objectivity, reproducibility safety this technique. Methods We included 103 consecutive patients who underwent biopsy last 48 months with wide spectrum diseases. Median stiffness (expressed as kilopascals – kPa) was kept...
Summary Background Liver stiffness measurements may have potential for detecting and monitoring hepatic fibrosis in chronic liver disease. Aim To study the detection, quantification progression of primary biliary cirrhosis by measurements. Methods were generated 80 patients with applying transient elastography; however, as there 55 biopsy, histological stage (METAVIR) compared only these patients. The efficiency predicting was determined from area under receiver operating characteristics...
INTRODUCTION: Obeticholic acid (OCA) and fibrates therapy results in biochemical improvement placebo-controlled trials patients with primary biliary cholangitis insufficient response to ursodeoxycholic acid. There is scarce information outside of clinical trials. Therefore, we have assessed the effectiveness adverse events these treatments. METHODS: Data from included ColHai registry treated OCA, fibrates, or both were recorded during a year, as well treatment discontinuation. RESULTS:...
Pembrolizumab, a programmed cell death receptor (PD-1) inhibitor, have improved the prognosis in several types of cancer. Despite important clinical benefits, checkpoint inhibition been associated with inflammatory and immune-related side effects (irAE).
detection of early-stage colorectal carcinoma (CRC)--( Dukes A or B)--provides better survival rates in these patients. Thus, the effectiveness screening programs asymptomatic patients early diagnosis symptomatic individuals has been postulated. The aim this study was to establish whether a delay other factors are related CRC stage.a retrospective performed on 96 with CRC. Age at diagnosis, gender distribution, intestinal disorders, delay, primary sign and -regarding CRC- localization, stage...
Iron overload caused by hereditary hemochromatosis (HH) increases free reactive oxygen species that, in turn, induce lipid peroxidation. Its 4-hydroxynonenal (HNE) by-product is a well-established marker of peroxidation since it reacts with accessible proteins deleterious consequences. Indeed, elevated levels HNE are often detected wide variety human diseases related to oxidative stress. Here, we evaluated HNE-modified the membrane erythrocytes from HH patients and organs Hfe-/- male female...
Background: the efficacy of combination therapy with peginterferon plus ribavirin to eradicate viral infection in patients chronic hepatitis C (CHC) is well established; moreover, it able arrest or even reverse liver fibrosis.Aims: analyze measurements hepatic stiffness as an index fibrosis using transient elastography (TE) who underwent a sustained virological response (SVR) during long-term follow-up; comparing changes severity non-responders patients.Material and methods: after was...
The use of direct-acting antivirals (DAA) for the hepatitis C virus (HCV) has yielded a significant improvement in treatment autoimmune (AIH) associated with HCV infection. Interferon was cornerstone therapy before introduction these agents into clinical practice. Herein, we report case an HCV-infected patient who developed interferon-induced AIH and since then, received immunosuppressive therapy. Administration DAA resulted sustained virologic response (SVR) remission which allowed...