A5029513289- Circadian rhythm and melatonin
- Sleep and Wakefulness Research
- Photoreceptor and optogenetics research
- Dietary Effects on Health
- Genetics, Aging, and Longevity in Model Organisms
- Liver Disease Diagnosis and Treatment
- Neuroendocrine regulation and behavior
- Regulation of Appetite and Obesity
- Spaceflight effects on biology
- Sleep and related disorders
- Hepatitis C virus research
- Retinal Development and Disorders
- Liver Diseases and Immunity
- Assembly Line Balancing Optimization
- Gastric Cancer Management and Outcomes
- Synthetic Organic Chemistry Methods
- Impact of Light on Environment and Health
- Gastrointestinal disorders and treatments
- Lymphoma Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Cancer Treatment and Pharmacology
- Neurobiology and Insect Physiology Research
- Liver Disease and Transplantation
- Inflammatory Bowel Disease
- Helicobacter pylori-related gastroenterology studies
Institut des Neurosciences Cellulaires et Intégratives
2016-2025
Centre National de la Recherche Scientifique
2015-2025
Dirección Regional de Salud del Callao
2024
Hospital Universitario de La Princesa
2005-2024
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2011-2024
Université de Strasbourg
2014-2023
Centre National pour la Recherche Scientifique et Technique (CNRST)
2015-2020
Centro de Investigación Biomédica en Red
2018
University of Wisconsin–Madison
2014-2017
Pontifical Catholic University of Peru
2016
The suprachiasmatic nuclei (SCN) of the hypothalamus contain master mammalian circadian clock, which is mainly reset by light. Temporal restricted feeding, a potent synchronizer peripheral oscillators, has only weak influence on light-entrained rhythms via SCN, unless feeding coupled with calorie restriction, thereby altering phase angle photic synchronization. Effects daytime were investigated mouse system. Normocaloric at midday led to predominantly diurnal (60%) food intake and decreased...
High-fat feeding in rodents leads to metabolic abnormalities mimicking the human syndrome, including obesity and insulin resistance. These diseases are associated with altered temporal organization of many physiological functions. The master circadian clock located suprachiasmatic nuclei controls most functions processes. Furthermore, under certain conditions (hypocaloric diet), cues capable altering clock's responses light. To determine whether high-fat (hypercaloric diet) can also affect...
In high or moderate risk populations, periodic surveillance of patients at progression from gastric precursor lesions (PL) to cancer (GC) is the most effective strategy for reducing burden GC. Incomplete type intestinal metaplasia (IIM) may be considered as best candidate, but it still controversial and more research needed. To further assess subtypes IM predictors GC occurrence.A follow-up study was carried-out including 649 patients, diagnosed with PL between 1995-2004 in 9 participating...
Abstract Exposure to light at night (LAN) is associated with insomnia in humans. Light provides the main input master clock hypothalamic suprachiasmatic nucleus (SCN) that coordinates sleep-wake cycle. We aimed develop a rodent model for effects of LAN on sleep. Therefore, we exposed male Wistar rats either 12 h (150–200lux):12 dark (LD) schedule or (150–200 lux):12 dim white (5 lux) (LDim) schedule. LDim acutely decreased amplitude daily rhythms REM and NREM sleep, further decrease over...
The cerebellum participates in motor coordination as well numerous cerebral processes, including temporal discrimination. Animals can predict daily timing of food availability, manifested by food-anticipatory activity under restricted feeding. By studying ex vivo clock gene expression situ hybridization and recording vitro Per1-luciferase bioluminescence, we report that the contains a circadian oscillator sensitive to feeding cues (i.e., whose oscillations are shifted response feeding)....
Summary Background Transient elastography is a novel and non‐invasive technique for the evaluation of fibrosis in chronic liver disease. Few studies that exist value efficacy transient elastography, mainly hepatitis C virus‐infected patients. Aim To evaluate effectiveness, objectivity, reproducibility safety this technique. Methods We included 103 consecutive patients who underwent biopsy last 48 months with wide spectrum diseases. Median stiffness (expressed as kilopascals – kPa) was kept...
Arboreal herbivory is rare among mammals. The few species with this lifestyle possess unique adaptions to overcome size-related constraints on nutritional energetics. Sloths are folivores that spend most of their time resting or eating in the forest canopy. A three-toed sloth will, however, descend its tree weekly defecate, which risky, energetically costly and, until now, inexplicable. We hypothesized behaviour sustains an ecosystem fur sloths, confers cryptic benefits sloths. found more...
Summary Background Liver stiffness measurements may have potential for detecting and monitoring hepatic fibrosis in chronic liver disease. Aim To study the detection, quantification progression of primary biliary cirrhosis by measurements. Methods were generated 80 patients with applying transient elastography; however, as there 55 biopsy, histological stage (METAVIR) compared only these patients. The efficiency predicting was determined from area under receiver operating characteristics...
The ability to cope with endogenous or host-generated reactive oxygen species is considered a key virulence attribute of the opportunistic pathogen Enterococcus faecalis, leading cause hospital-acquired infections. In this study, we used in silico and mutational analyses identify characterize role Spx global regulator oxidative stress tolerance E. faecalis. While Δspx strain grew as well wild-type under anaerobic conditions, mutant exhibited impaired growth aerobic conditions was highly...
Abstract Food is considered a potent Zeitgeber for peripheral oscillators but not the suprachiasmatic nucleus (SCN), which entrained principally by light–dark cycle. However, when food attains relevant properties in quantity and quality, it can be even SCN. Here we evaluated entrainment influence of daily palatable meal, without regular deprivation, on circadian rhythm locomotor activity c‐Fos PER‐1 protein expression Rats fed ad libitum , constant darkness, received meal 6 weeks starting...
The kisspeptin (Kp) neurons in the anteroventral periventricular nucleus (AVPV) are essential for preovulatory LH surge, which is gated by circulating estradiol (E2) and time of day. We investigated whether AVPV Kp intact female mice may be site both E2 daily signals integrated these host a circadian oscillator involved timed surge. In afternoon proestrous day, immunoreactivity displayed marked transient decrease 2 hours before contrast, content was stable throughout day diestrus, when...