A5066156355- Cancer Risks and Factors
- Global Cancer Incidence and Screening
- Lymphoma Diagnosis and Treatment
- Birth, Development, and Health
- Nutritional Studies and Diet
- BRCA gene mutations in cancer
- Breast Cancer Treatment Studies
- Multiple and Secondary Primary Cancers
- Pregnancy and preeclampsia studies
- Genetic Associations and Epidemiology
- Air Quality and Health Impacts
- Testicular diseases and treatments
- Sleep and Work-Related Fatigue
- Legal Systems and Judicial Processes
- Urological Disorders and Treatments
- Menopause: Health Impacts and Treatments
- Gestational Diabetes Research and Management
- Mechanical Circulatory Support Devices
- Cancer-related molecular mechanisms research
- Estrogen and related hormone effects
- Cancer survivorship and care
- Chronic Lymphocytic Leukemia Research
- Multicultural Socio-Legal Studies
- Legal principles and applications
- Occupational and environmental lung diseases
University of York
2025
Rogers (United States)
2023
Mercy Hospital
2023
Cooper Green Mercy Hospital
2023
Mercy Medical Center
2023
Institute of Cancer Research
2016-2021
UNSW Sydney
2017
The association between increasing body mass index (BMI; calculated as weight in kilograms divided by height meters squared) and risk of breast cancer is unique epidemiology that a crossover effect exists, with reduction before increase after menopause. inverse premenopausal poorly characterized but might be important the understanding causation.
Plausible biological reasons exist regarding why smoking could affect breast cancer risk, but epidemiological evidence is inconsistent. We used serial questionnaire information from the Generations Study cohort (United Kingdom) to estimate HRs for in relation adjusted potentially confounding factors, including alcohol intake. Among 102,927 women recruited 2003–2013, with an average of 7.7 years follow-up, 1815 developed invasive cancer. The HR (reference group was never smokers) 1.14 (95% CI...
Parity is widely recognized as protective for breast cancer, but cancer risk may be increased shortly after childbirth. Whether this varies with breastfeeding, family history of or specific tumor subtype has rarely been evaluated.
Menopausal hormone therapy (MHT) increases breast cancer risk; however, most cohort studies omit MHT use after enrolment and many infer menopausal age. We used information from serial questionnaires the UK Generations Study to estimate hazard ratios (HRs) for among post-menopausal women with known age, examined biases induced when not updating data on including inferred Among recruited in 2003–2009, at 6 years of follow-up, 58 148 had reached menopause 96% completed a follow-up...
Women diagnosed with breast cancer frequently attribute their to psychological stress, but scientific evidence is inconclusive. We investigated whether experienced frequency of stress and adverse life events affect subsequent risk. Breast incidence was analysed respect variables collected at enrolment in a prospective cohort study 106,000 women the United Kingdom, 1783 incident cases. Relative risks (RR) were obtained as hazard ratios using Cox proportional hazards models. There no...
It is plausible that night shift work could affect breast cancer risk, possibly by melatonin suppression or circadian clock disruption, but epidemiological evidence inconclusive. Using serial questionnaires from the Generations Study cohort, we estimated hazard ratios (HR) and 95% confidence intervals (95%CI) for in relation to being a worker within last 10 years, adjusted potential confounders. Among 102,869 women recruited 2003–2014, median follow-up 9.5 2059 developed invasive cancer. The...
Among premenopausal women, higher body mass index (BMI) is associated with lower breast cancer risk, although the underlying mechanisms are unclear. Investigating adiposity distribution may help clarify impacts on risk. This study was initiated to investigate associations of central and peripheral risk overall by other factors characteristics. We used individual-level data from 14 prospective cohort studies estimate hazard ratios (HRs) for using Cox proportional hazards regression. Analyses...
Early-adulthood body size is strongly inversely associated with risk of premenopausal breast cancer. It unclear whether subsequent changes in weight affect risk. We pooled individual-level data from 17 prospective studies to investigate the association change cancer risk, considering strata initial weight, timing change, other factors and subtype. Hazard ratios (HR) 95% confidence intervals (CI) were obtained using Cox regression. Among 628,463 women, 10,886 diagnosed before menopause....
Parity and age at first pregnancy are well-established risk factors for breast cancer, but the effects of other characteristics pregnancies uncertain literature is inconsistent.In a cohort 83,451 parous women from general population UK, which collected detailed information on each wide range potential confounders, we investigated associations length gestation birthweight offspring in woman's with her cancer risk, adjusting full non-reproductive as well reproductive unlike previous large...
Preeclampsia and hyperemesis gravidarum are pregnancy complications associated with altered sex hormone levels. Previous studies suggest preeclampsia may be a decreased risk of subsequent breast cancer an increased risk, but the evidence remains unclear. We used data from Generations Study, large prospective study women in United Kingdom, to estimate relative risks relation history using Cox regression adjusting for known factors. During 7.5 years average follow-up 82,053 parous women, 1,969...
19503 Background: Because patients with testicular lymphoma are rare and generally excluded from clinical trials, data on features,treatment survival limited. Methods: We retrospectively reviewed all cases of adult (age ≥18 years) registered the NCDB 1985–2004. Survival were available only for diagnosed before 2001. The NCDB, a project American College Surgeons Commission Cancer, serves as comprehensive surveillance resource forms cancer captures approximately 75% in US. Results:...
The inexperience and limited resources at non-tertiary medical centers pose unique challenges to the successful development of an extracorporeal membrane oxygenation (ECMO) program. current literature does not provide a detailed framework that addresses encountered these facilities. We outline proactive approach developing ECMO program retrospective analysis patient demographics, clinical characteristics, configuration, duration support, major adverse events, survival hospital discharge....
The history of gestational diabetes mellitus (GDM) has been associated with breast cancer risk in some studies, particularly young women, but results cohort studies are conflicting.We pooled data from 257 290 (age <55 years) women five cohorts. We used multivariable Cox proportional-hazards regression to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between GDM cancer, overall by oestrogen receptor (ER) status, before age 55 years, adjusted established...
<div>Abstract<p>Breast cancer is a leading diagnosis among premenopausal women around the world. Unlike rates in postmenopausal women, incidence of advanced breast have increased recent decades for women. Progress identifying contributors to risk has been constrained by limited numbers cases individual studies and resulting low statistical power subcategorize exposures or study specific subtypes. The Premenopausal Breast Cancer Collaborative Group was established facilitate...
<p>Supplementary table 1: Overview of the number cohort studies providing information on each type risk factor in pooled data set</p>
<p>Supplementary table 1: Overview of the number cohort studies providing information on each type risk factor in pooled data set</p>
<div>Abstract<p>Breast cancer is a leading diagnosis among premenopausal women around the world. Unlike rates in postmenopausal women, incidence of advanced breast have increased recent decades for women. Progress identifying contributors to risk has been constrained by limited numbers cases individual studies and resulting low statistical power subcategorize exposures or study specific subtypes. The Premenopausal Breast Cancer Collaborative Group was established facilitate...