A5082244311- Cell Adhesion Molecules Research
- Chronic Kidney Disease and Diabetes
- Connective Tissue Growth Factor Research
- Protease and Inhibitor Mechanisms
- Diabetes Treatment and Management
- Liver Disease Diagnosis and Treatment
- Neuropeptides and Animal Physiology
- Liver Diseases and Immunity
- Peptidase Inhibition and Analysis
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Systemic Sclerosis and Related Diseases
- Advanced Glycation End Products research
- Renal Diseases and Glomerulopathies
- Liver physiology and pathology
- Cardiovascular Function and Risk Factors
- S100 Proteins and Annexins
- Adenosine and Purinergic Signaling
- Neurological and metabolic disorders
- Antiplatelet Therapy and Cardiovascular Diseases
- Diabetes and associated disorders
- Peripheral Artery Disease Management
- Diabetes Management and Research
- Parathyroid Disorders and Treatments
- Biomedical Research and Pathophysiology
- Platelet Disorders and Treatments
Nordic Bioscience (Denmark)
2016-2024
Gentofte Hospital
2020
University of Southern Denmark
2016-2018
Institute of Molecular Medicine
2018
Copenhagen University Hospital
2015-2017
Rigshospitalet
2015-2017
Endotrophin, a collagen type VI-derived peptide, mediates metabolic dysregulation, inflammation, and fibrosis in animal models, but has not been studied human heart failure (HF).
Type 2 diabetes is a common risk factor for the development of chronic kidney disease (CKD). Enhanced de novo collagen type VI (COL VI) formation has been associated with renal fibrosis and CKD. We investigated hypothesis that PRO-C6, product specifically generated during COL formation, prognostic adverse outcomes in patients microalbuminuria.In prospective, observational study, we measured PRO-C6 serum (S-PRO-C6) urine (U-PRO-C6) 198 microalbuminuria without symptoms coronary artery...
The development of accurate non-invasive tests to detect and measure the extent fibrosis disease activity in patients with non-alcoholic steatohepatitis (NASH) - progressive phenotype fatty liver (NAFLD) is great clinical importance. Herein, we aimed validate performance PRO-C3 ADAPT for detection moderate/severe within CENTAUR screening population.PRO-C3 was assessed plasma from population phase IIb study (NCT02217475) adults NASH fibrosis. relation between histologic features evaluated, as...
Abstract Renal fibrosis is the central pathogenic process in progression of chronic kidney disease (CKD). Collagen type VI (COL VI) upregulated renal fibrosis. Endotrophin released from COL and promotes pleiotropic pro-fibrotic effects. Kidney severity varies considerably accurate information regarding CKD may improve clinical decisions. We tested hypothesis that urinary endotrophin derived during deposition fibrotic human kidneys a marker for Impairment Secondary Care (RIISC) cohort,...
There is a need for noninvasive biomarkers that can identify patients with progressive liver fibrosis and monitor response to antifibrotic therapy. An equally important identification of spontaneous regression, since they may not treatment nor be included in clinical studies as end point. Circulating biomarkers, originating from defined fragments the scar tissue itself, serve valuable tools this aspect precision medicine. We investigated panel serological collagen formation degradation...
Serum microRNA (miRNA) levels are known to change in non-alcoholic fatty liver disease (NAFLD) and may serve as useful biomarkers. This study aimed profile miRNAs comprehensively at all NAFLD stages.
OBJECTIVE Patients with type 1 diabetes (T1D) have a higher risk of developing chronic kidney disease, cardiovascular events (CVEs), and mortality than the general population. We hypothesized that two previously published biomarkers, namely PRO-C6, biomarker collagen VI formation, C3M, III degradation, may be associated impaired renal function prognostic value for adverse renal, CVE, in patients T1D. RESEARCH DESIGN AND METHODS PRO-C6 C3M serum (sPRO-C6, sC3M) urine (uPRO-C6, uC3M) were...
Renal fibrosis is a hallmark of chronic kidney disease (CKD) caused by an imbalance between formation and degradation extracellular matrix proteins. We investigated the collagen turnover profile 81 non-dialysis CKD stage 2-5 patients measuring peptides reflecting type (COL) I, III, IV, VI. Based on profile, we identified four clusters patients. Cluster 1 contained one patient with prostate cancer, who had distinct turnover. The other generally severe (Cluster 2), moderate 4), or mild 3). 4...
Renal fibrosis is the hallmark of chronic kidney disease (CKD) and characterized by an imbalanced extracellular matrix remodelling. Endotrophin (ETP) a signalling molecule released from collagen type VI (COL VI). ETP can be measured PRO-C6 assay, which quantifies levels COL formation. were previously associated with mortality progression in patients CKD. We hypothesized that serum urinary correlate degree interstitial biopsies immunoglobulin A nephropathy (IgAN) anti-neutrophil cytoplasmic...
•A normal reference range in healthy adult volunteers was established for PRO-C3.•PRO-C3 levels were not affected by age, sex, BMI, or ethnicity.•PRO-C3 increased with liver fibrosis stage.•PRO-C3 identified patients significant and advanced fibrosis. Background & AimsProgressive has been as the major predictor of mortality non-alcoholic fatty disease (NAFLD). Several biomarkers are currently being evaluated their ability to substitute biopsy standard. Recent clinical studies NAFLD/NASH...
Renal fibrogenesis is associated with increased ECM remodeling and release of collagen fragments in urine progressive renal disease. We investigated the diagnostic value urinary degradation products a proteinuria-driven fibrosis rat model without anti-fibrotic S1P-receptor modulator FTY720 treatment. Proteinuria was induced male Wistar rats by Adriamycin (ADR) injection (n = 16). Healthy served as controls 12). Six weeks post-injection, all underwent biopsy, FTY720-treatment started ADR-rats...
Natural cytokine-specific autoantibodies (c-aAb) have been measured in healthy and diseased individuals, considered as both endogenous immune-regulators pathogenic factors. Overall, the etiology potential pathology of c-aAb are still undefined. To further characterize sero-prevalence, predictors consequences high levels, we performed largest population-based study to date, using participants epidemiological data from Danish Blood Donor Study. Using a validated bead-based multiplex assay...
Background Diabetic kidney disease is a major cause of morbidity and mortality. Dysregulated turnover collagen type III associated with development fibrosis. We investigated whether degradation product (C3M) was risk marker for progression chronic (CKD), occurrence cardiovascular (CVD), mortality during follow up in people 2 diabetes (T2D) microalbuminuria. Moreover, we C3M correlated markers inflammation endothelial dysfunction at baseline. Methods measured serum (sC3M) urine (uC3M) 200...
Tubulointerstitial fibrosis is a major pathological feature in chronic kidney disease (CKD) and collagen type III (COL3) component of the renal fibrotic scar. We hypothesized that dysregulated turnover COL3 an important determinant CKD progression. assessed relationship between fragments reflecting active formation (PRO-C3) degradation (C3M) progression mortality prospective cohort patients.We measured PRO-C3 C3M urine (uPRO-C3 uC3M) serum (sPRO-C3 sC3M) 500 patients from Renal Impairment...
Delayed graft function after kidney transplantation is common and increases morbidity health care costs. There evidence that endotrophin, a specific fragment of pro-collagen type VI, promotes the inflammatory response in diseases. We tested hypothesis pretransplant endotrophin transplant recipients may be associated with risk delayed function. Pretransplant plasma was assessed using an enzyme-linked immunosorbent assay three independent cohorts 806 recipients. The primary outcome function,...
Abstract Extracellular matrix (ECM) remodeling is a hallmark of the pathology gastrointestinal disorders. Collagen type VI (COL6) produced by fibroblasts, and COL6 α3-chain has shown to be elevated in patients with ulcerative colitis (UC), Crohn’s disease (CD) colorectal cancer (CRC). Measuring COL6α3 serum may therefore have potential as biomarker for The aims this study were develop validate competitive ELISA targeting specific neo-epitope evaluate its associations disorders UC, CD CRC,...
OBJECTIVE We investigated endotrophin, a profibrotic signaling molecule reflecting collagen VI formation, in serum and urine as risk marker for complications to type 2 diabetes. RESEARCH DESIGN AND METHODS Endotrophin was measured 774 individuals with Outcomes included composite kidney end point, first major adverse cardiovascular event (MACE), mortality, progression of albuminuria, incident heart failure, sight-threatening eye disease. Adjusted Cox proportional hazards models were applied....
Abstract Background Enhanced de-novo collagen type VI (COL VI) formation has been associated with kidney and cardiovascular fibrosis. We hypothesized that endotrophin (ETP), a product specifically generated during formation, may be prognostic for heart failure (HF), death (CVD), endpoints, all-cause mortality in patients 2 diabetes. Methods measured ETP plasma (P-ETP) urine (U-ETP) samples collected at baseline follow-up (year 3) from the randomized controlled trial, CANagliflozin...