A5081084572- Photodynamic Therapy Research Studies
- Photoreceptor and optogenetics research
- Cell Adhesion Molecules Research
- Photosynthetic Processes and Mechanisms
- RNA Interference and Gene Delivery
- Immunotherapy and Immune Responses
- Radiopharmaceutical Chemistry and Applications
- Galectins and Cancer Biology
- Inflammatory Bowel Disease
- Dendrimers and Hyperbranched Polymers
- Redox biology and oxidative stress
- Angiogenesis and VEGF in Cancer
- Light effects on plants
- Nanoplatforms for cancer theranostics
Aarhus University
2019-2022
Technical University of Denmark
2020-2021
Nordic Bioscience (Denmark)
2017
Abstract Extracellular matrix (ECM) remodeling is a hallmark of the pathology gastrointestinal disorders. Collagen type VI (COL6) produced by fibroblasts, and COL6 α3-chain has shown to be elevated in patients with ulcerative colitis (UC), Crohn’s disease (CD) colorectal cancer (CRC). Measuring COL6α3 serum may therefore have potential as biomarker for The aims this study were develop validate competitive ELISA targeting specific neo-epitope evaluate its associations disorders UC, CD CRC,...
Light-oxygen-voltage (LOV) proteins that bind flavin mononucleotide (FMN) have received attention as optogenetic systems can photosensitize the production of singlet molecular oxygen, O2(a1Δg). Although seminal compound in this family, mini oxygen generator (miniSOG), does not make O2(a1Δg) appreciable yield, it is a convenient standard against which other photosensitizing (SOPPs) be judged. SOPP3 re-engineered version miniSOG selectively produces high yield but, when localized cell,...
Protein-encased chromophores that photosensitize the production of reactive oxygen species, ROS, have been center recent activity in studies oxidative stress. One potential attribute such systems is local environment surrounding chromophore, and determines chromophore's photophysics, ideally remains constant independent global into which system placed. Therefore, a protein-encased sensitizer localized mitochondria would arguably same photophysics as at plasma membrane, for example. thus...
C-reactive protein (CRP) is widely used as biomarkers of infection and inflammation. It has a well-described ability to bind phosphocholine (PC), well PC-clusters from compromised inflamed cell membranes tissues. The binding CRP interest this determines subsequent innate immune activity. We investigated PC-decorated dendrimers mimics for PC-clusters. Five generations poly(propylene imine) (PPI) were modified with PC surface groups via three-step synthetic sequence obtaining the in high...