Hayley Irusen
A5031204099- Genetic Associations and Epidemiology
- Health Systems, Economic Evaluations, Quality of Life
- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Economic and Financial Impacts of Cancer
- Ethics in Clinical Research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- COVID-19 and Mental Health
- Cancer survivorship and care
- Genetics, Bioinformatics, and Biomedical Research
- COVID-19 and healthcare impacts
- Breastfeeding Practices and Influences
- Optimism, Hope, and Well-being
- Advances in Oncology and Radiotherapy
- Tracheal and airway disorders
- Genetic and phenotypic traits in livestock
- Global Health and Surgery
- Cancer Risks and Factors
- Patient-Provider Communication in Healthcare
- Cardiovascular Disease and Adiposity
- Global Cancer Incidence and Screening
- Cleft Lip and Palate Research
Stellenbosch University
2013-2024
Western Cape Department of Health
2015-2022
Beth Israel Deaconess Medical Center
2018
University of Abuja Teaching Hospital
2018
University College Hospital, Ibadan
2018
Dana-Farber Cancer Institute
2018
Abstract Although prostate cancer is the leading cause of mortality for African men, vast majority known disease associations have been detected in European study cohorts. Furthermore, most genome-wide association studies used genotyping arrays that are hindered by SNP ascertainment bias. To overcome these disparities genomic medicine, Men Descent and Carcinoma Prostate (MADCaP) Network has developed a array optimized populations. The MADCaP Array contains more than 1.5 million markers an...
Cancer of the prostate (CaP) is leading cancer among men in sub-Saharan Africa (SSA). A substantial proportion these with CaP are diagnosed at late (usually incurable) stages, yet little known about etiology SSA.
The health profile of older adults places them at risk infirmity and death from COVID-19 which may induce anxiety or exacerbate pre-existing anxiety. We examined related in men undergoing treatment for prostate cancer (CaP).This study was conducted between July September 2020. Sixty participants a larger prospective, longitudinal assessing depression, quality life with localized (DAHCaP) were included. measured single time point using, the Corona Virus Anxiety Scale (CAS). In addition,...
Purpose Health research in low- and middle-income countries can generate novel scientific knowledge improve clinical care, fostering population health improvements to prevent premature death. Project management is a critical part of the success this research, applying knowledge, skills, tools, techniques accomplish required goals. Here, we describe development implementation tools support multifaceted study prostate cancer Africa, focusing on building strategic operational capacity. Methods...
Background Comorbid depression and anxiety in men with localised prostate cancer (CaP) largely go undiagnosed untreated their effects on health-related quality of life (HRQOL) CaP should not be underestimated. We examined the prevalence its association HRQOL about to commence treatment for differences between groups, radical prostatectomy (RP) radiation therapy (RT). Method One hundred seven participants from a longitudinal prospective observational study assessing depression, (DAHCaP), were...
PURPOSE Globally, there were 19.3 million new cancer cases and 10 deaths, with the African continent contributing approximately 1.1 over 700,000 deaths to global burden in 2020. High quality research is required understand etiology risk factors for common cancers region develop context specific strategies aimed at minimizing future Africa. Our study addresses a significant gap knowledge resources available training project management (PM) workforce METHODS We developed evaluated program...
Abstract Although prostate cancer is the leading cause of mortality for African men, vast majority known disease associations have been detected in European study cohorts. Furthermore, most genome-wide association studies used genotyping arrays that are hindered by SNP ascertainment bias. To overcome these disparities genomic medicine, M en A frican D escent and Ca rcinoma P rostate (MADCaP) Network has developed a array optimized populations. The MADCaP Array contains more than 1.5 million...
Decisional conflict (DC) is a psychological construct that an individual experiences in making decision involves risk, loss, regret, or challenges to one's values. This study assessed DC cohort of South African men undergoing curative treatment for localised prostate cancer (LPC). The objectives were (1) examine the association between and knowledge (PCK), demographics, state anxiety, anxiety time (2) compare levels groups [prostatectomy (RP) external beam radiation (RT)].Data, comprising...
You have accessJournal of UrologyGlobal Health/Humanitarian (MP67)1 Sep 2021MP67-18 CLINICAL CHARACTERISTICS OF PROSTATE CANCER PATIENTS IN WEST AND SOUTH AFRICA THE MEN AFRICAN DESCENT CARCINOMA (MADCAP) CONSORTIUM STUDY Mohamed Jalloh, Denzel Zhu, Ilir Agalliu, Caroline Andrews, Evan Kovac, Ben Adusei, Nana Yaa Snyper, James Mensah, Victoria Okyne, Ann Hsing, Akindele Adebiyi, Olufemi Ogunbiyi, Olayiwola Shittu, Peter Olabode, Maxwell Nwegbu, Oseremen Aisuodionoe-Shadrach, Pedro Fernandez,...
<div>Abstract<p>Although prostate cancer is the leading cause of mortality for African men, vast majority known disease associations have been detected in European study cohorts. Furthermore, most genome-wide association studies used genotyping arrays that are hindered by SNP ascertainment bias. To overcome these disparities genomic medicine, Men Descent and Carcinoma Prostate (MADCaP) Network has developed a array optimized populations. The MADCaP Array contains more than 1.5...
<p>Figure S1. Cross-validation error in ADMIXTURE analyses. The best fit to data occurs at K = 3.</p>
<p>Markers used in PRS calculations. This list includes all markers from the Schumacher et al. 2018 CaP (10) as well proxy that are found on MADCaP Array. Chromosome and positions (build hg38) listed here for Allele frequencies PBS scores also included 139 Numbers of each genotyping array within 50kb CaP-associated loci here.</p>
<p>Successfully called markers on the MADCaP Array. This tab-delimited file includes genomic positions, inclusion criteria, and overlap with other arrays.</p>
<p>Comprehensive list of cancer-associated loci with African allele frequencies and PBS scores. This dataset includes a total 2,477 unique markers yielding 3,557 disease or trait associations</p>
<p>This .xlsx file lists Axiom genotyping solution QC thresholds. Genotyping metrics for both pegs of the MADCaP Array are listed here. This also includes Benjamini-Hochberg adjusted p-values (FDR = 5%) pairwise comparisons derived allele frequencies, ancestry proportions cases and controls, cumulative runs homozygosity, PRS distributions.</p>
<p>Comprehensive list of cancer-associated loci with African allele frequencies and PBS scores. This dataset includes a total 2,477 unique markers yielding 3,557 disease or trait associations</p>
<p>Figure S1. Cross-validation error in ADMIXTURE analyses. The best fit to data occurs at K = 3.</p>
<p>Markers used in PRS calculations. This list includes all markers from the Schumacher et al. 2018 CaP (10) as well proxy that are found on MADCaP Array. Chromosome and positions (build hg38) listed here for Allele frequencies PBS scores also included 139 Numbers of each genotyping array within 50kb CaP-associated loci here.</p>
<p>This .xlsx file lists Axiom genotyping solution QC thresholds. Genotyping metrics for both pegs of the MADCaP Array are listed here. This also includes Benjamini-Hochberg adjusted p-values (FDR = 5%) pairwise comparisons derived allele frequencies, ancestry proportions cases and controls, cumulative runs homozygosity, PRS distributions.</p>
<p>Successfully called markers on the MADCaP Array. This tab-delimited file includes genomic positions, inclusion criteria, and overlap with other arrays.</p>
<div>Abstract<p>Although prostate cancer is the leading cause of mortality for African men, vast majority known disease associations have been detected in European study cohorts. Furthermore, most genome-wide association studies used genotyping arrays that are hindered by SNP ascertainment bias. To overcome these disparities genomic medicine, Men Descent and Carcinoma Prostate (MADCaP) Network has developed a array optimized populations. The MADCaP Array contains more than 1.5...