A5064488455- Genetic Associations and Epidemiology
- Cancer Immunotherapy and Biomarkers
- Epilepsy research and treatment
- Traumatic Brain Injury Research
- Pharmacological Effects and Toxicity Studies
- Immunotherapy and Immune Responses
- Cancer Genomics and Diagnostics
- Neuroscience and Neuropharmacology Research
- CAR-T cell therapy research
- Prostate Cancer Treatment and Research
- Cutaneous Melanoma Detection and Management
- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- Nutrition, Genetics, and Disease
- Immune cells in cancer
- Drug Transport and Resistance Mechanisms
- Hair Growth and Disorders
- Cardiac Arrest and Resuscitation
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- RNA regulation and disease
- Health Systems, Economic Evaluations, Quality of Life
- HIV-related health complications and treatments
- Biotechnology and Related Fields
- Anesthesia and Pain Management
- Genetics, Bioinformatics, and Biomedical Research
University of Michigan
2024-2025
Georgia Institute of Technology
2017-2025
Harbor–UCLA Medical Center
2008-2024
Phoenix Children's Hospital
2024
University of Arizona
2024
University of Washington
2016-2024
UCLA Medical Center
2008-2024
Massachusetts General Hospital
2020-2024
Cleveland Clinic
2023
Western University
2017-2023
Accurate assessment of health disparities requires unbiased knowledge genetic risks in different populations. Unfortunately, most genome-wide association studies use genotyping arrays and European samples. Here, we integrate whole genome sequence data from global populations, results thousands (GWAS), extensive computer simulations to identify how disease can be misestimated.In contrast null expectations, find that risk allele frequencies at known loci are significantly for African...
Abstract Purpose: Programmed cell death receptor-1 (PD-1) inhibitors are frontline therapy in advanced melanoma. Severe immune-related adverse effects (irAEs) often require immunosuppressive treatment with glucocorticoids (GCCs), but GCC use and its correlation patient survival outcomes during anti–PD-1 monotherapy remains unclear. Experimental Design: In this multicenter retrospective analysis, patients treated between 2009 2019 detailed use, data were identified from five independent...
Programmed cell death receptor-1 (PD-1) monotherapy is a standard treatment for advanced cutaneous melanoma, but its efficacy and toxicity are defined in white populations remain poorly characterized other ethnic groups, such as East Asian, Hispanic African.To determine the of PD-1 different groups.Clinical data patients with unresectable or melanoma treated anti-PD-1 between 2009 2019 were collected retrospectively from five independent institutions USA, Australia China. Tumour response,...
This study examined the effects of aging and cognitive impairment on medication finance management in an HIV sample. We observed main age (older < younger) neuropsychological functional task performance. Interactions between cognition demonstrated that older impaired individuals performed significantly more poorly than all other comparison groups. There were no relationships laboratory performance self-reported management. The interaction advancing may confer significant limitations for be...
The constellation of physical, cognitive, and emotional symptoms, collectively known as postconcussion syndrome (PCS), is not uniquely associated with concussion, making the etiology chronic symptoms controversial. current study compared percentages individuals meeting symptom-based criteria for PCS in a population-based sample veterans composed subgroups various psychiatric diagnoses, history mild traumatic brain injury (MTBI), healthy controls. Participants were identified from 4462...
<h3>Objective</h3> To develop and externally validate models to predict the probability of postoperative naming decline in adults following temporal lobe epilepsy surgery using easily accessible preoperative clinical predictors. <h3>Methods</h3> In this retrospective, prediction model development study, multivariable were developed a cohort 719 patients who underwent at Cleveland Clinic validated 138 one 3 centers United States (Columbia University Medical Center, Emory School Medicine,...
Abstract Background Genome-wide association studies do not always replicate well across populations, limiting the generalizability of polygenic risk scores (PRS). Despite higher incidence and mortality rates prostate cancer in men African descent, much what is known about genetics comes from populations European descent. To understand how genetic predictions perform different we evaluated test characteristics PRS three previous using data UK Biobank a novel dataset 1298 cases 1333 controls...
Children undergoing placement of bilateral myringotomy tubes (BMT) often exhibit pain-related behavior (agitation) in the postanesthesia care unit. We compared emergence and recovery profiles pediatric patients who received sevoflurane with or without supplementary intranasal fentanyl for BMT surgery. By using a prospective, double-blinded design, 150 children 6 mo to 5 yr age, scheduled routine surgery, were anesthetized (2%–3%) 60% N2O/O2 gas mixture. Patients randomized receive equal...
Tonsillectomy is associated with postoperative nausea and vomiting (PONV) if no prophylaxis administered. Previous studies have shown that a single dose of dexamethasone decreases the incidence PONV. The most effective to affect clinical outcome yet be defined.One-hundred-twenty-five children were enrolled in double-blind, prospective, randomized, dose-escalating study dexamethasone: 0.0625, 0.125, 0.25, 0.5, or 1 mg/kg, maximum 24 mg. Nonparametric ANOVA was used analyze by treatment group...
The present study examined the impact of cognitive reserve in maintaining intact neuropsychological (NP) function among older HIV-positive individuals, a uniquely at-risk subgroup. Participants included 129 individuals classified by HIV serostatus, age group, and NP impairment. A three-way analysis variance (ANOVA) followed series within-group ANOVA multiple regression analyses were conducted to investigate pattern (vs. other protective) influence groups with varying risks Results indicated...
The ubiquitous pannexin 1 (Panx1) ion- and metabolite-permeable channel mediates the release of ATP, a potent signalling molecule. In present study, we provide striking evidence that in turn, stimulates internalization Panx1 to intracellular membranes. These findings hold important implications for understanding regulation when extracellular ATP is elevated. nervous system, this includes phenomena such as synaptic plasticity, pain, precursor cell development stroke; outside things like...
To evaluate declarative memory outcomes in medically refractory epilepsy patients who underwent either a highly selective laser ablation of the amygdalohippocampal complex or conventional open temporal lobe resection.
Abstract Although prostate cancer is the leading cause of mortality for African men, vast majority known disease associations have been detected in European study cohorts. Furthermore, most genome-wide association studies used genotyping arrays that are hindered by SNP ascertainment bias. To overcome these disparities genomic medicine, Men Descent and Carcinoma Prostate (MADCaP) Network has developed a array optimized populations. The MADCaP Array contains more than 1.5 million markers an...
To develop a model to predict the probability of mood decline in adults following temporal lobe resection for treatment pharmacoresistant epilepsy.Variable selection was performed on 492 patients from Cleveland Clinic using best subsets regression. After completing variable selection, subset variables requested four epilepsy surgery centers across North America (n = 100). All data were combined final postoperative (N 592). Internal validation with bootstrap resampling performed. A clinically...
Many cancer patients treated with immune checkpoint blockade (ICB) do not have durable treatment responses. Circulating biomarkers the potential to identify primary resistance or early progression on therapy alter course and avoid unnecessary toxicity. Unbiased multimodal proteomic profiling in blood has been underexplored due previously limited scalability of multiplexing technologies cohorts lacking time-series sampling. To address this, we performed plasma >2,900 proteins...
Androgenetic alopecia is a highly heritable trait. However, much of our understanding about the genetics male pattern baldness comes from individuals European descent. Here, we examined dataset comprising 2,136 men Ghana, Nigeria, Senegal, and South Africa that were genotyped using MADCaP Array. We first tested how genetic predictions generalize Europe to found polygenic scores GWAS yielded AUC statistics ranged 0.513 0.546, indicating generalized poorly African populations. Subsequently,...
The authors investigated the relationship between antiretroviral adherence and HIV-associated verbal memory impairment. HIV-positive participants demonstrated poorer than HIV-negative participants. Both good (≥90%) poor (<90%) adherers displayed encoding deficits as compared with controls, but only exhibited retrieval deficits. Encoding primarily accounted for reduced delayed recall in adherers, both adherers. difference groups might be explained by a neuroprotective effect of or preexisting...
The Minnesota Multiphasic Personality Inventory-2 (MMPI-2) Fake Bad Scale (FBS; Butcher, Dahlstrom, Graham, Tellegen, & Kaemmer, 1989) has been shown to be sensitive somatic over-endorsement. However, the impact of ethnicity not examined on FBS, which is concern given some studies that show increased rates endorsement in particular ethnic groups. We evaluated FBS performance 190 Caucasian American, Hispanic, and African American outpatients who were obtained from two different clinical...
Abstract Objective Patients and other stakeholders generally report high satisfaction with neuropsychological evaluations (NPEs), but no research has examined effects of cognitive, emotional, factors that often prompt evaluations. A prospective, quasi-experimental study was conducted to examine self-reported cognitive psychiatric symptoms, self-efficacy, motivation, following a NPE. Method Participants from neuropsychology clinic who were diagnosed AD/HD and/or DSM-IV mood disorder based on...
Introduction: In 2010, the New York State Legislature made it mandatory to offer an HIV test people aged 13–64 years receiving hospital or primary care services, with limited exceptions. this study, we used data from City practices evaluate impact of law on testing rates in ambulatory care. Methods: We collected quarterly electronic health records 218 practices. calculated overall and stratified crude rates. Using univariate multivariate generalized estimating equation models, assessed odds...