A5050240310- Cancer Immunotherapy and Biomarkers
- Chemokine receptors and signaling
- Healthcare Systems and Technology
- Nanoplatforms for cancer theranostics
- Pancreatic and Hepatic Oncology Research
- Child and Adolescent Health
- Antimicrobial Peptides and Activities
- Cancer Genomics and Diagnostics
- Cancer Research and Treatments
- Veterinary Equine Medical Research
- Cancer-related molecular mechanisms research
- Immunotherapy and Immune Responses
- Adolescent and Pediatric Healthcare
- Mobile Health and mHealth Applications
- Muscle Physiology and Disorders
- Exercise and Physiological Responses
- Cancer Cells and Metastasis
- RNA Research and Splicing
- Pain Mechanisms and Treatments
- vaccines and immunoinformatics approaches
- Health Literacy and Information Accessibility
- Patient Satisfaction in Healthcare
- Telemedicine and Telehealth Implementation
Carnegie Mellon University
2024
Broad Institute
2024
University of Pittsburgh
2019-2021
Children's Hospital of Pittsburgh
2020-2021
Many cancer patients treated with immune checkpoint blockade (ICB) do not have durable treatment responses. Circulating biomarkers the potential to identify primary resistance or early progression on therapy alter course and avoid unnecessary toxicity. Unbiased multimodal proteomic profiling in blood has been underexplored due previously limited scalability of multiplexing technologies cohorts lacking time-series sampling. To address this, we performed plasma >2,900 proteins...
Telemedicine is the use of telecommunication technology to remotely provide healthcare services. Evaluation telemedicine often relies on administrative data, but validity identifying encounters in data not known. The objective this study was assess accuracy billing codes for use.In retrospective within a large integrated health system from January 2016 December 2017, we examined live-interactive and store-and-forward compared manual chart review. To further examine external validity, applied...
Background e-Consultations between primary care physicians and specialists are a valuable means of improving access to specialty care. Adolescents young adults (AYAs) face unique challenges in accessing limited adolescent medicine resources, which contributes delayed or forgone general pediatricians may alleviate these barriers However, the optimal application this model requires careful attention nuances AYA Objective This study aims qualitatively analyze feedback obtained during iterative...
Summary Key mechanisms underlying chronic pain occur within the neural circuitry of dorsal horn. Recent genome-wide association studies (GWAS) have identified genetic variants associated with predisposition to pain. However, most these lie in regulatory non-coding regions that so far not been linked spinal cord function. Here, we take a multi-species approach determine whether impact elements horn neurons. We first built more comprehensive single cell atlas; filling gaps by generating...
Abstract Most patients treated with immune checkpoint blockade (ICB) do not have durable treatment responses, stressing a critical need to identify early non-invasive biomarkers of response. Circulating provide easy access for serial monitoring and can insight on the mechanisms response ICB. We performed plasma proteomics (~3000 proteins) 250 metastatic melanoma before ICB analysis response- time point-associated peripheral protein biomarkers. next generated patient-matched blood lymphocyte...
Abstract Epithelial-mesenchymal transition (EMT) is a hallmark of pancreatic ductal adenocarcinoma (PDAC) invasion. In general, cellular plasticity major contributor to both tumor progression and therapy resistance. The goals our study are 1) directly quantitatively measure in PDAC3 cell lines, 2) identify candidate genes that could alter the cancer cells. By understanding regulation plasticity, we may find ways perturb cells prevent towards treatment resistant states. A strict definition...
Abstract Pancreatic cancer (PDAC) is a lethal disease in part because tumor cells exist distinct transcriptional states (e.g. basal/mesenchymal v.s. classical/epithelial) with unique phenotypic properties that contribute to growth and treatment resistance. Two major mechanisms have been suggested for evasion: (1) the intrinsic resistance of an existing state therapy regimen (2) plasticity therapy-sensitive adopt more resistant states. The relative contribution these still poorly understood....
Abstract This abstract is being presented as a short talk in the scientific program. A full printed Proffered Abstracts section (PR018) of Conference Program/Proceedings. Citation Format: Samuel J. Wright, Izabella Zamora, Milan Parikh, Deepika Yeramosu, Lynn Bi, Sarah Kang, Marijana Rucevic, Moshe Sade-Feldman, Baolin Liu, Ngan Nguyen, Jamey Guess, Alexis Schneider, David Lieb, Elliot Woods, William Michaud, Aleigha R. Lawless, Tatyana Sharova, Gyulnara Kasumova, Michelle S. Kim, Ryan Park,...
Abstract Most patients treated with immune checkpoint blockade (ICB) do not have durable treatment responses, stressing a critical need to identify early non-invasive biomarkers of response. Circulating provide easy access for serial monitoring and can insight on the mechanisms response ICB. We performed plasma proteomics (2943 proteins) 250 metastatic melanoma before ICB analysis response- time point-associated peripheral protein biomarkers. next generated patient- matched blood lymphocyte...
<sec> <title>BACKGROUND</title> e-Consultations between primary care physicians and specialists are a valuable means of improving access to specialty care. Adolescents young adults (AYAs) face unique challenges in accessing limited adolescent medicine resources, which contributes delayed or forgone general pediatricians may alleviate these barriers However, the optimal application this model requires careful attention nuances AYA </sec> <title>OBJECTIVE</title> This study aims qualitatively...