Caveolin-1 (Cav1) is an integral membrane, scaffolding protein found in plasma membrane invaginations (caveolae). Cav1 regulates multiple cancer-associated processes. In breast cancer, a tumor suppressive role for has been suggested; however, frequently overexpressed aggressive cancer subtypes, suggesting oncogenic function advanced-stage disease. To further delineate progression, we evaluated its expression levels among panel of cell lines representing spectrum phenotypes. basal-like (the...

Growth performance, digestive and absorptive capacities target of rapamycin (TOR), ribosomal protein S6 kinase 1 (S6K1) eIF4E-binding (4E-BP) gene expression in the hepatopancreas intestine juvenile grass carp (Ctenopharyngodon idellus) fed graded ratios dietary alpha-linolenic acid/linoleic acid (ALA/LNA) (0.01, 0.34, 0.68, 1.03, 1.41, 1.76 2.15) for 60 days were investigated. The results showed that ALA/LNA ratio 1.03 significantly improved (i) per cent weight gain (PWG) feed efficiency,...

The present study explored the effect of glutamine and vitamin E on growth anti-oxidation capacity isolated fish enterocytes. Fish enterocytes were cultured with six medium, respectively, containing 0, 2.0, 4.7, 6.8, 8.1, 9.2 mmol L−1 for 64 h. results showed that could promote proliferation differentiation. different medium 2.5, 3.5, 4.5, 6.0, 7.0 μg mL−1 96 cells differentiation not significantly enhanced, but anti-superoxide anion activity, anti-hydroxy radical reduced glutathione...

A 9-week feeding trial was carried out with juvenile Jian carp to study the effect of dietary pantothenic acid (PA) on growth, body composition and intestinal enzyme activities. Semi-purified diets seven levels (4.0, 15.5, 25.6, 36.1, 45.9, 56.1 65.9 mg PA kg−1) supplemental calcium d-pantothenate were fed (13.0 ± 0.0 g). improved specific growth rate (SGR), protein productive value (PPV), efficiency ratio (PER) lipid production (LPV) (P < 0.05). Fish control diet had significantly lower...

A 6-week trial was carried out with 900 juvenile Jian carp (Cyprinus carpio var. Jian) to investigate the effects of dietary zinc on growth, body composition and intestinal enzyme activities. Diets supplemented increasing levels (15.3, 26.9, 40.8, 58.2, 68.9 92.5 mg Zn kg−1) lactate were fed (mean initial weight 15.7 ± 0.01 g). Results indicated that per cent gain (PWG), feed efficiency (FE), protein ratio (PER) lipid productive value (LPV) enhanced up 40.8 kg−1 diet (P < 0.05), plateaued...

A total of 900 juvenile Jian carp (Cyprinus carpio var. Jian) (7.99 ± 0.02 g) were fed diets containing graded levels xylanase at 220 (unsupplemented control), 650, 1070, 1480, 1810 and 2470 U kg−1 diet for 10 weeks to investigate the effects on growth performance, intestinal enzyme activities microflora. The per cent weight gain, feed efficiency, protein efficiency ratio, production value, lipid ash calcium value phosphorus retention ratio significantly improved with increasing up a point,...

This study was conducted to the effects of dietary zinc on lipid peroxidation, protein oxidation and antioxidant defence juvenile Jian carp (Cyprinus carpio var. Jian) by feeding fish with increasing levels (15.3, 26.9, 40.8, 58.2, 68.9 92.5 mg Zn kg⁻¹) for 6 weeks. Results indicated that malondialdehyde (MDA) content carbonyls (PC) in serum were highest fed diet containing 15.3 kg⁻¹ (P 0.05). Serum antihydroxy radical (AHR), catalase (CAT) glutathione-S-transferase (GST) activities followed...

A total of 1200 juvenile Jian carp (Cyprinus carpio var. Jian) (8.76 ± 0.02 g) were fed diets containing graded levels histidine at 2.3 (unsupplemented control), 4.4, 6.3, 8.6, 10.8 and 12.7 g kg−1 diet for 60 days to investigate the effects on growth performance, body composition, intestinal enzymes activities microflora. Specific rate (SGR), feed efficiency, protein efficiency ratio, productive value, content lipid fish lowest in basal (P < 0.05). Activities glutamate-pyruvate transaminase...

A 56-day feeding trial was carried out to investigate the effect of dietary glutamate (Glu) supplementation on growth performance, digestive enzyme activities and intestinal antioxidant capacity grass carp (Ctenopharyngodon idella). total 540 with average initial weight 370 ± 3.8 g were fed three diets supplemented 0, 8 16 kg−1 Glu. The per cent gain, specific rate, feed conversion ratio, protein lipid productive value significantly improved by Glu supplementation. Feed intake, condition...

The objective of this study was to determine if a moderate or high reduction dietary CP, supplemented with indispensable amino acids (IAA), would affect growth, intestinal morphology and immunological parameters pigs. A total 40 barrows (initial BW=13.50±0.50 kg, 45±2 day age) were used in completely randomized block design, allocated four treatments containing CP levels at 20.00%, 17.16%, 15.30% 13.90%, respectively. Industrial AA added meet the IAA requirements After 4-week feeding, blood...

A total of 1050 juvenile Jian carp (Cyprinus carpio var. Jian) (8.20 ± 0.02 g) were fed diets containing seven graded levels thiamin (0.25, 0.48, 0.79, 1.06, 1.37, 1.63 and 2.65 mg kg−1) for 60 days to investigate the effects on growth, body composition digestive enzyme activities. Percent weight gain (PWG), feed intake efficiency (FE) lowest in fish basal diet (P < 0.05). Protein productive value lipid increased with increasing dietary up 1.06 0.79 kg−1 diet, respectively Body protein...

Oxidative damage and antioxidant status of intestine hepatopancreas for juvenile Jian carp (Cyprinus carpio var. Jian) fed graded levels methionine hydroxy analogue (MHA: 0, 5.1, 7.6, 10.2, 12.7, 15.3 g kg−1 diet) 60 days were studied. Radical scavenging ability, enzymes activities such as superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST), glutathione peroxidase (GPX) reducase (GR), well (GSH), protein carbonyl (PC) malondialdehyde (MDA) contents assayed in these...

To investigate effects of iron (Fe) on growth, haematological parameters, flesh quality and antioxidant status in muscle, young grass carp (Ctenopharyngodon idella) (292.0 ± 3.2 g) were fed graded levels Fe (20.7, 38.4, 52.8, 79.3, 98.0 120.0 mg kg−1 diet) for 8 weeks. Per cent weight gain (PWG) feed intake improved with up to 52.8 diet. Serum Fe, erythrocyte counts, haemoglobin (Hb), haematocrit mean cell increased optimal (38.4–79.3 (P < 0.05). The muscle protein lipid contents by dietary...

A total of 1050 Jian carp, Cyprinus carpio var. (23.39 ± 0.06 g) were randomly divided into seven groups each three replicates, which fed respectively with semi-purified diets contained 1.25, 2.71, 4.22, 5.78, 7.23, 8.83 and 11.44 mg riboflavin kg−1 diet for 6 weeks. The results showed that significantly improved percent weight gain, specific growth rate, feed efficiency protein ratio at the level 4.22 diet. Gross retention lipid production value increasing dietary levels from 1.25 to 5.78...

This study investigated the effects of myo-inositol (MI) on growth and antioxidant capacity carp enterocytes. The enterocytes were incubated in media containing 0, 15, 30, 45, 60 75 mg MI L−1 for 96 h. results indicated that could increase cell viability. In addition, activities cellular alkaline phosphatase (AKP), gamma-glutamyl transpeptidase (γ-GT), Na+, K+-adenosine trisphosphatase (Na+, K+-ATPase) creatinkinase (CK) increased with supplementation at levels ranging from 15 to medium,...

The effects of exogenous salicylic acid (SA), sodium nitropusside (SNP, a nitric oxide donor), or their combination on dwarf polish wheat (Triticum polonicum L.) seedlings under UV-B stress were studied. significantly decreased plant height, shoot dry mass, pigment content, net photosynthetic rate, intercellular CO2 concentration, stomatal conductance, transpiration and variable to maximum chlorophyll fluorescence ratio (Fv/Fm) in all plants, but less the presence SA, SNP, combination. On...

This study investigated the effects of phenylalanine on growth, digestive and absorptive ability antioxidant status young grass carp (Ctenopharyngodon idella). Young were fed diets containing 3.4 (basal diet), 6.1, 9.1, 11.5, 14.0 16.8 g kg−1 diet with a fixed 10.7 tyrosine for 8 weeks. Percent weight gain (PWG), feed efficiency intake fish lowest in basal (P < 0.05). Trypsin, lipase amylase activities hepatopancreas, antioxidants including glutathione contents reducase hepatopancreas...

A 76-day feeding trial was carried out to evaluate the effects of Lysine and Methionine supplementation on growth digestive capacity grass carp (Ctenopharyngodon idella) fed plant protein diets using high-level canola meal (CM). Fish with initial average weight 103.9 ± 0.6 g were three extruded diets. (FM) diet formulated as normal control 40 kg−1 FM 300 CM; CM prepared by replacing all (total 340 kg−1) without Lys or Met supplementation; supplement (CMS) similar but supplemented essential...

As a novel form of nonapoptotic cell death, ferroptosis is developing into promising therapeutic target dedifferentiating and therapy-refractory cancers. However, its application in pancreatic cancer still unknown. In the preliminary research, we found that F-box WD repeat domain-containing 7 (FBW7) inhibited migration proliferation cells through substrate c-Myc. We further another key FBW7, KLF5, could inhibit ferroptosis. Inhibiting KLF5 significantly enhances cytotoxicity oxaliplatin...

Abstract Background The polygenic risk score (PRS) has been perceived as advantageous in predicting the of complex diseases compared to other measures. We aimed systematically evaluate influence PRS on disease outcome and explore its predictive value. Methods comprehensively assessed relationship between 32 UK Biobank. used Cox models estimate effects incidence risk. Then, we constructed prediction assess clinical utility prediction. For 16 diseases, further capability across early...

Abstract Background There are numerous methods available for predicting sepsis following Percutaneous Nephrolithotomy. This study aims to compare the predictive value of Quick Sequential Organ Failure Assessment (qSOFA), Systemic Inflammatory Response Syndrome (SISR), National Early Warning Score (NEWS), interleukin-6 (IL-6), and procalcitonin (PCT) septicemia. Methods Patients who underwent percutaneous nephrolithotomy were included in divided into a control group septic shock group. The...