A5041687430- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Genetic factors in colorectal cancer
- Global Cancer Incidence and Screening
- Occupational Health and Safety Research
- Colorectal Cancer Surgical Treatments
- Lung Cancer Diagnosis and Treatment
- Prostate Cancer Diagnosis and Treatment
- Workplace Violence and Bullying
- Injury Epidemiology and Prevention
- Prostate Cancer Treatment and Research
- Agriculture and Farm Safety
- Air Quality and Health Impacts
- Per- and polyfluoroalkyl substances research
- Traffic and Road Safety
- Cancer, Lipids, and Metabolism
- Lung Cancer Treatments and Mutations
- Statistical Methods in Clinical Trials
- Colorectal Cancer Treatments and Studies
- Gut microbiota and health
- Esophageal Cancer Research and Treatment
- Diverticular Disease and Complications
- Radiomics and Machine Learning in Medical Imaging
- Cardiac electrophysiology and arrhythmias
- Cancer Immunotherapy and Biomarkers
University of Minnesota
2016-2025
Minnesota Department of Health
2016-2025
University of Minnesota System
2003-2025
University of Minnesota Medical Center
2018-2024
Twin Cities Orthopedics
2003-2023
Catapult
2020-2021
Center for Environmental Health
2010-2021
Minneapolis Institute of Arts
2001-2020
International Chemical Workers Union
2018
National Institute for Occupational Safety and Health
2018
Although tests for occult blood in the feces are widely used to screen colorectal cancers, there is no conclusive evidence that they reduce mortality from this cause. We evaluated a fecal occult-blood test randomized trial and documented its effectiveness.We randomly assigned 46,551 participants 50 80 years of age screening cancer once year, every two years, or control group. Participants who were screened submitted six guaiac-impregnated paper slides with smears each three consecutive...
The effect of screening with prostate-specific–antigen (PSA) testing and digital rectal examination on the rate death from prostate cancer is unknown. This first report Prostate, Lung, Colorectal, Ovarian (PLCO) Cancer Screening Trial prostate-cancer mortality.
Abstract In the United States, colorectal cancer (CRC) is fourth most common diagnosed among adults and second leading cause of death from cancer. For this guideline update, American Cancer Society (ACS) used an existing systematic evidence review CRC screening literature microsimulation modeling analyses, including a new evaluation age to begin by race sex additional that incorporates changes in US incidence. Screening with any one multiple options associated significant reduction incidence...
Breast cancer is a leading cause of premature mortality among US women. Early detection has been shown to be associated with reduced breast morbidity and mortality.To update the American Cancer Society (ACS) 2003 screening guideline for women at average risk cancer.The ACS commissioned systematic evidence review literature inform supplemental analysis mammography registry data address questions related interval. Formulation recommendations was based on quality judgment (incorporating values...
Both annual testing for fecal occult blood and biennial significantly reduce mortality from colorectal cancer. However, the effect of screening on incidence cancer remains uncertain, despite diagnosis removal precancerous lesions in many persons who undergo screening.
Laboratory and epidemiologic data suggest that aspirin has an antineoplastic effect in the large bowel.
Context Screening for ovarian cancer with antigen 125 (CA-125) and transvaginal ultrasound has an unknown effect on mortality.Objective To evaluate the of screening mortality in Prostate, Lung, Colorectal Ovarian (PLCO) Cancer Trial.Design, Setting, Participants Randomized controlled trial 78 216 women aged 55 to 74 years assigned undergo either annual (n=39 105) or usual care 111) at 10 centers across United States between November 1993 July 2001.Intervention The intervention group was...
The National Lung Screening Trial (NLST) is a randomized multicenter study comparing low-dose helical computed tomography (CT) with chest radiography in the screening of older current and former heavy smokers for early detection lung cancer, which leading cause cancer-related death United States. Five-year survival rates approach 70% surgical resection stage IA disease; however, more than 75% individuals have incurable locally advanced or metastatic disease, latter having 5-year less 5%. It...
The prostate component of the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial was undertaken to determine whether there is a reduction in cancer mortality from screening using serum prostate-specific antigen (PSA) testing digital rectal examination (DRE). Mortality after 7–10 years follow-up has been reported previously. We report extended 13 trial. A total 76 685 men, aged 55–74 years, were enrolled at 10 centers between November 1993 July 2001 randomly assigned...
Lung cancer is the largest contributor to mortality from cancer. The National Screening Trial (NLST) showed that screening with low-dose helical computed tomography (CT) rather than chest radiography reduced lung We describe screening, diagnosis, and limited treatment results initial round of in NLST inform improve lung-cancer-screening programs.
The benefits of endoscopic testing for colorectal-cancer screening are uncertain. We evaluated the effect with flexible sigmoidoscopy on incidence and mortality.
Laboratory and epidemiological data suggest that folic acid may have an antineoplastic effect in the large intestine.To assess safety efficacy of supplementation for preventing colorectal adenomas.A double-blind, placebo-controlled, 2-factor, phase 3, randomized clinical trial conducted at 9 centers between July 6, 1994, October 1, 2004. Participants included 1021 men women with a recent history adenomas no previous invasive intestine carcinoma.Participants were randomly assigned 1:1 ratio...
The National Lung Screening Trial (NLST) used risk factors for lung cancer (e.g., ≥30 pack-years of smoking and <15 years since quitting) as selection criteria lung-cancer screening. Use an accurate model that incorporates additional to select persons screening may identify more who have or in whom will develop.
BACKGROUND: In 1993, a randomized controlled trial in Minnesota showed, after 13 years of follow-up, that annual fecal occult blood testing was effective reducing colorectal cancer mortality by at least 33%. Biennial screening (i.e., every 2 years) resulted only 6% reduction. Two European trials (in England andin Denmark) subsequently showed statistically significant 15% and 18% reductions with biennial screening. Herein, we provide updated results —through 18 follow-up— from the address...
In randomized trials, fecal occult-blood testing reduces mortality from colorectal cancer. However, the duration of benefit is unknown, as are effects specific to age and sex.In Minnesota Colon Cancer Control Study, 46,551 participants, 50 80 years age, were randomly assigned usual care (control) or annual biennial screening with testing. Screening was performed 1976 through 1982 1986 1992. We used National Death Index obtain updated information on vital status participants determine causes...
Abstract The American Cancer Society (ACS) recommends that individuals with a cervix initiate cervical cancer screening at age 25 years and undergo primary human papillomavirus (HPV) testing every 5 through 65 (preferred); if HPV is not available, then aged to should be screened cotesting (HPV in combination cytology) or cytology alone 3 (acceptable) ( strong recommendation ). ACS >65 who have no history of intraepithelial neoplasia grade 2 more severe disease within the past years,...
<h3>Background</h3> As screening methods for colorectal cancer (CRC) are limited by uptake and adherence, further options sought. A blood test might increase both, but none has yet been tested in a setting. <h3>Objective</h3> We prospectively assessed the accuracy of circulating methylated <i>SEPT9</i> DNA (mSEPT9) detecting CRC population. <h3>Design</h3> Asymptomatic individuals ≥50 years old scheduled colonoscopy at 32 US German clinics voluntarily gave plasma samples before colon...
The effect on mortality of screening for lung cancer with modern chest radiographs is unknown.To evaluate the using in Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial.Randomized controlled trial that involved 154,901 participants aged 55 through 74 years, 77,445 whom were assigned to annual screenings 77,456 usual care at 1 10 centers across United States between November 1993 July 2001. data from a subset eligible National Lung Trial (NLST), which compared radiograph...
Aims: To identify the magnitude of and potential risk factors for violence within a major occupational population. Methods: Comprehensive surveys were sent to 6300 Minnesota licensed registered (RNs) practical (LPNs) nurses collect data on physical non-physical prior 12 months. Re-weighting enabled adjustment biases associated with non-response, accounting unknown eligibility. Results: From 78% responding, combined non-response rate information, respective adjusted rates per 100 persons year...
The National Lung Screening Trial (NLST) showed that screening with low-dose computed tomography (CT) as compared chest radiography reduced lung-cancer mortality. We examined the cost-effectiveness of CT in NLST. estimated mean life-years, quality-adjusted life-years (QALYs), costs per person, and incremental ratios (ICERs) for three alternative strategies: CT, radiography, no screening. Estimations were based on number observed deaths occurred during trial projected survival persons who...
The National Lung Screening Trial was conducted to determine whether three annual screenings (rounds T0, T1, and T2) with low-dose helical computed tomography (CT), as compared chest radiography, could reduce mortality from lung cancer. We present detailed findings the first two incidence T1 T2). evaluated rate of adherence participants screening protocol, results downstream diagnostic tests, features lung-cancer cases, first-line treatments, we estimated performance characteristics both...
<h3>Objective</h3> Some individuals are diagnosed with colorectal cancer (CRC) despite recent colonoscopy. We examined under colonoscopic surveillance for colonic adenomas to assess possible reasons diagnosing after a colonoscopy complete removal of any identified polyps. <h3>Design</h3> Primary data were pooled from eight large (>800 patients) North American studies in which participants adenoma(s) had baseline (with intent remove all visualised lesions) and followed subsequent used an...