A5025103490- Corneal Surgery and Treatments
- Ocular Surface and Contact Lens
- Corneal surgery and disorders
- Ocular Infections and Treatments
- Glaucoma and retinal disorders
- Ocular Diseases and Behçet’s Syndrome
- Herpesvirus Infections and Treatments
- Salivary Gland Disorders and Functions
- Intraocular Surgery and Lenses
- Proteoglycans and glycosaminoglycans research
- Connexins and lens biology
- Systemic Lupus Erythematosus Research
- Ocular Oncology and Treatments
- Dermatology and Skin Diseases
- Skin and Cellular Biology Research
- Legionella and Acanthamoeba research
- Mycobacterium research and diagnosis
- Dermatologic Treatments and Research
- Innovations in Medical Education
- Bartonella species infections research
- Nonmelanoma Skin Cancer Studies
- Advanced Glycation End Products research
- Brain Metastases and Treatment
- Facial Rejuvenation and Surgery Techniques
- Immune Response and Inflammation
University of Miami
1990-2025
Memorial Health System
2025
Jackson Memorial Hospital
2025
Washington University in St. Louis
2009-2024
Brown University
2024
Children's Hospital & Medical Center
2024
University of Nebraska Medical Center
2024
California Pacific Medical Center
2013-2019
University of California, Los Angeles
2019
University of Pennsylvania
2019
To map the thickness, elevation (anterior and posterior corneal surface), axial curvature of cornea in normal eyes with Orbscan topography system.94 51 subjects were investigated using system. The anterior maps classified into regular ridge, irregular incomplete island, unclassified patterns, power grouped round, oval, symmetric bow tie, asymmetric patterns. pachymetry patterns designated as decentred oval.The thinnest point on was located at an average 0.90 (SD 0. 51) mm from visual axis...
Abstract Objective To investigate the relationship of fatigue severity to other clinical features in primary Sjögren's syndrome (SS) and identify factors contributing physical mental aspects fatigue. Methods We identified 94 subjects who met American‐European Consensus Group criteria for classification SS. Fatigue was assessed with a visual analog scale, Severity Scale (FSS), Profile (ProF). Associations were compared using multivariate regression. Results Abnormal fatigue, defined as an FSS...
Objective More than 80% of autoimmune disease predominantly affects females, but the mechanism for this female bias is poorly understood. We suspected that an X chromosome dose effect accounts this, and we undertook study to test our hypothesis trisomy (47,XXX; occurring in ∼1 1,000 live births) would be increased patients with female‐predominant diseases (systemic lupus erythematosus [SLE], primary Sjögren's syndrome [SS], biliary cirrhosis, rheumatoid arthritis [RA]) compared without...
As a protective mechanism, the cornea is sensitive to noxious stimuli. Here, we show that in mice, high proportion of corneal TRPM8+ cold-sensing fibers express heat-sensitive TRPV1 channel. Despite its insensitivity cold, enhances membrane potential changes and electrical firing neurons response cold stimulation. This elevated neuronal excitability leads augmented ocular nociception mice. In model dry eye disease, expression increased, results severe allodynia. Overexpression sensory...
Many epithelial compartments undergo constitutive renewal in homeostasis but activate unique regenerative responses following injury. The clear corneal epithelium is crucial for vision and renewed from limbal stem cells (LSCs). Using single-cell RNA sequencing, we profiled the mouse homeostasis, aging, diabetes, dry eye disease (DED), where tear deficiency predisposes cornea to recurrent In capture transcriptional states that accomplish continuous tissue turnover. We leverage our dataset...
Using an in vivo rabbit model system, we have studied the morphological and biochemical changes corneal, conjunctival, esophageal epithelia during vitamin A deficiency. Light electron microscopy showed that three undergo different degrees of keratinization. Corneal conjunctival became heavily keratinized, forming multiple layers superficial, anucleated cornified cells. In contrast, epithelium underwent only minor changes. To correlate alterations with expression specific keratin molecules,...
Endogenous sex hormone levels are associated with risks of breast cancer overall and estrogen receptor (ER)-positive tumors; however, their associations ER-negative tumors remain unclear.In a case-cohort study within the Women's Health Initiative Observational Study among postmenopausal women aged 50-79 years, we examined between endogenous testosterone estradiol ER-positive cancers. Serum bioavailable were assessed at baseline visit in 317 invasive case subjects subcohort 594 women....
Sjögren's syndrome (SS) is a common, autoimmune exocrinopathy distinguished by keratoconjunctivitis sicca and xerostomia. Patients frequently develop serious complications including lymphoma, pulmonary dysfunction, neuropathy, vasculitis, debilitating fatigue. Dysregulation of type I interferon (IFN) pathway prominent feature SS correlated with increased autoantibody titers disease severity. To identify genetic determinants IFN dysregulation in SS, we performed cis-expression quantitative...
To evaluate human tear fluid for transforming growth factor beta isoforms 1 and 2 (TGF-beta1 TGF-beta2).To accomplish this, tears were evaluated TGF-betas by quantitative antibody sandwich ELISA (sELISA), mink lung epithelial cell (MLEC) inhibition bioassay western blotting. Various physical chemical treatments used to activate TGF-beta in these assays.TGF-betas could not be detected untreated or heated sELISA; however, mean TGF-beta1 concentrations of 2.32 ng/ml acid-activated sELISA....
This study aimed to review the clinical features, therapeutic response, and histopathology of cases nontuberculous mycobacterial keratitis at Bascom Palmer Eye Institute.Retrospective medical records, photographs, histopathology, microbiology 24 acid-fast over past 15 years.Causal organisms included Mycobacterium chelonae (16), M. fortuitum (3), avium-intracellulare (2), nonchromogenicum (1), triviale asiaticum (1). Clinically, had a superficial location except in those patients with history...