A5018984603- Systemic Lupus Erythematosus Research
- Rheumatoid Arthritis Research and Therapies
- Anesthesia and Sedative Agents
- Blood transfusion and management
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Optical Network Technologies
- Cardiac, Anesthesia and Surgical Outcomes
- Medical Research and Treatments
- Advanced Optical Network Technologies
- Advanced Photonic Communication Systems
- Autoimmune and Inflammatory Disorders Research
- Peer-to-Peer Network Technologies
- Access Control and Trust
- Anesthesia and Pain Management
- Distributed and Parallel Computing Systems
- Hip and Femur Fractures
- Herpesvirus Infections and Treatments
- Inflammasome and immune disorders
- Cardiac and Coronary Surgery Techniques
- Chronic Lymphocytic Leukemia Research
- Caching and Content Delivery
- Prenatal Screening and Diagnostics
- Chronic Disease Management Strategies
- Parvovirus B19 Infection Studies
- Periodontal Regeneration and Treatments
Sichuan University
1969-2025
West China Hospital of Sichuan University
1969-2025
Dalian Medical University
2025
Second Affiliated Hospital of Dalian Medical University
2025
Dalian University of Technology
2025
Pudong Medical Center
2025
Fudan University
2025
Southern Medical University Shenzhen Hospital
2024
Army Medical University
2024
State Grid Corporation of China (China)
2020-2023
Objective Tofacitinib is an oral Janus kinase (JAK) inhibitor for the treatment of rheumatoid arthritis (RA). The pathways affected by tofacitinib and effects on gene expression in situ are unknown. Therefore, synovial pathobiology were investigated. Methods A randomised, double-blind, phase II serial biopsy study (A3921073; NCT00976599 ) patients with RA inadequate methotrexate response. Patients background received 10 mg twice daily or placebo 28 days. Synovial biopsies performed Days -7...
Tofacitinib is an oral JAK inhibitor for the treatment of rheumatoid arthritis (RA). Systemic inflammation proposed to play a fundamental role in altered lipid metabolism associated with RA; however, underlying mechanisms are unknown. We undertook this study compare cholesterol and lipoprotein kinetics patients active RA those matched healthy volunteers.This was phase I open-label mechanism-of-action study. Cholesterol were assessed (13) C-cholesterol C-leucine infusions. reevaluated after...
<h3>Objectives</h3> To evaluate the efficacy and safety of atorvastatin versus placebo in modifying lipids patients with rheumatoid arthritis (RA) receiving oral Janus kinase inhibitor, tofacitinib. <h3>Methods</h3> A randomised, controlled, multicentre phase 2 study, open-label for tofacitinib blinded atorvastatin. Patients received 10 mg twice daily 12 weeks; at week 6, were randomly assigned 1:1 to receive once or 6 weeks. Main outcome measures lipid moieties, American College...
Fiberoptic bronchoscopy is a complex procedure with the need for sufficient patient anesthesia/sedation while maintaining safety. This trial aimed to evaluate efficacy, safety, and pharmacokinetics of HSK3486 during fiberoptic bronchoscopy. multicenter, double-blind, randomized, non-inferiority, parallel-group phase 3 was conducted in patients who underwent Patients randomly received 0.4 mg/kg (N = 134) or propofol 2.0 133). The primary efficacy endpoint successful rate bronchoscopy,...
Abstract Background Ciprofol is a novel 2, 6-disubstituted phenolic derivative anesthetic that binds to the gamma-aminobutyric acid-A receptor. Aim To determine equally potent dose of ciprofol compared with propofol as an induction agent for general anesthesia in patients undergoing selective surgery, and assess its safety. Method A total 109 non-emergency, non-cardiothoracic or non-neurosurgical surgery requiring tracheal intubation were enrolled. Ten per group assigned ciprofol-0.3, 0.4...
Due to environmental hypoxia on the high-altitude local residents often exhibit a compensative increase in hemoglobin concentration maintain body's oxygen supply. In certain people, number of red blood cells continues grow, resulting high altitude polycythemia (HAPC) which is characterized by headache, disorientation, sleeplessness, and bone discomfort. HAPC associated with multiple complications, lower extremity arteriosclerosis obliterans (LEASO) rare. Here we report two long-term Tibetan...
Objective To explore herpes zoster ( HZ ) rates and live vaccine LZV safety in a subset of patients with rheumatoid arthritis who received before tofacitinib ± methotrexate MTX ), or adalimumab ADA plus the ORAL Strategy. Methods Strategy was 1‐year, phase IIIb/IV, randomized, triple‐dummy, active‐comparator–controlled study. ‐inadequate responder 5 mg twice daily (BID), BID , 40 every other week (1:1:1 randomization). Eligible age ≥50 years could opt to receive 28 days initiating study...
Objective This study aimed to investigate the association between Systemic Inflammatory Response Index (SIRI) and glaucoma using data from 2005–2008 National Health Nutrition Examination Survey (NHANES). Methods We performed a cross-sectional analysis NHANES (2005–2008). Among participants who underwent non-mydriatic retinal imaging Frequency Doubling Technology (FDT) visual field testing, 4,514 were included after excluding those with missing key variable data. SIRI other inflammatory...
Transsphenoidal endoscopic pituitary (TEP) tumor resection is performed through the nose via sphenoid sinus to remove tumors from gland. Also, enhanced recovery after surgery (ERAS) was adapted reduce physical and physiological traumatic stress response of surgical patients. A total 174 patients who underwent TEP in our department August 2021 June 2022 were randomly divided into non-ERAS group ERAS group. The main primary observational indicator postoperative self-care ability parameters...
Although numerous drugs have been associated with cataracts, the risk for most remains unclear. This study aimed to investigate factors drug-induced cataracts by analyzing large-scale data from U.S. Food and Drug Administration Adverse Event Reporting System (FAERS). We used reporting odds ratio (ROR) evaluate reports of in FAERS first quarter 2004 third 2024. A univariate analysis, LASSO (least absolute shrinkage selection operator) regression, a multivariate regression analysis were...
While extensive research has been conducted on isotretinoin's systemic side effects, studies focusing its ocular effects remain limited and often lack substantial sample sizes. To address this gap, we a comprehensive investigation of isotretinoin-related toxicity using data from the FAERS spanning 2004 to 2024. After excluding duplicate incomplete records database, identified 760 eye-related adverse event reports total 45,258 entries. We employed Reporting Odds Ratio (ROR) method assess risk...
Postoperative cognitive dysfunction (POCD) is a significant clinical issue. Its neuropathogenesis has not been clearly identified and effective interventions for use to reduce POCD have established. This study was designed determine whether environmental enrichment (EE) or (CE) reduces sex-determining region Y-box-2 regulated by sirtuin 1, plays role in the effect. Eighteen-month-old male mice were subjected right-common-carotid-artery exposure under sevoflurane anesthesia. Some of them...
The trail investigated the effect of small dose sufentanil or fentanyl administrated before end surgery in reducing incidence emergence agitation after anesthesia with sevoflurane preschool children undergoing ophthalmology surgery, and anesthesia.From September 2011 to January 2012 January, ninety ASA I-II children, aged from 3-7 years, West China Hospital, were randomly assigned three groups receive intravenous saline, 0.1μg/kg 1μg/kg at 20 minutes surgery. Children scored by scoring...
Intra-abdominal hypertension and abdominal compartment syndrome (ACS) are distinct clinical stages of pathology caused by increased intra-abdominal pressure, which may lead to respiratory circulatory dysfunction in children is associated with high pediatric mortality. An emergency exploratory laparotomy was planned for an infant ACS. After induction anesthesia endotracheal intubation, the patient developed ventilation failure any management ineffective. Ventilation resumed after a race...
Abstract Background Effective teaching methods are needed to improve students’ abilities in hand-eye coordination and understanding of cardiac anatomy echocardiography education. Simulation devices have emerged as innovative tools exhibited distinctive advantages due their ability provide vivid visual learning experiences. This study aimed investigate the effect simulation sectional human using ultrasound on outcomes satisfaction Methods The included 18 first-year clinical medical students...
Red-cell transfusion is critical for surgery during the peri-operative period; however, threshold remains controversial mainly owing to diversity among patients. The patient's medical status should be evaluated before making a decision. Herein, we developed an individualized strategy using West-China-Liu's Score based on physiology of oxygen delivery/consumption balance and designed open-label, multicenter, randomized clinical trial verify whether it reduced red cell requirement as compared...
To investigate the application of fetuses with talipes equinovarus(TE)using chromosomal microarray analysis(CMA)technology.From May 2012 to June 2015, 54 were found TE and or without other structural anomalies by prenatal ultrasound. Karyotyping was taking for them all, normal karyotypes took another CMA test. The data analyzed CHAS software. Finally all cases followed up know about their pregnancy outcomes.One detected abnormal karyotype which trisomy 18(2%, 1/54). undertaken remaining...
We propose an intelligent survivable RSA algorithm with multi agents based on deep reinforcement learning in EON to face multiple services and improve the survivability of network. Simulation result shows that proposed can reduce packet loss rate Improve resource utilization well.
<h3>Background</h3> Tofacitinib is a novel oral Janus kinase (JAK) inhibitor for the treatment of rheumatoid arthritis (RA). The specific JAK-STAT (signal transducer and activator transcription) pathways affected by tofacitinib downstream effects on gene expression in situ are not known. <h3>Objectives</h3> To understand how alters synovial biology RA, we performed prospective serial biopsy study. JAK inhibition histopathology, expression, signalling were determined correlated with clinical...
<h3>Background</h3> Tofacitinib is an oral JAK inhibitor for the treatment of RA. There no direct comparison tofacitinib monotherapy vs +MTX in MTX inadequate responders (IR) and limited data comparing (±MTX) adalimumab (ADA) patients (pts) with <h3>Objectives</h3> To compare efficacy safety monotherapy, tofacitinib+MTX, ADA+MTX a head-to-head, non-inferiority trial MTX-IR pts. <h3>Methods</h3> In this randomised, triple-dummy, active-controlled, 1-year, Phase 3b/4 (ORAL Strategy;...