Seidu A. Richard

ORCID: 0000-0003-3475-0363
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About
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Research Areas
  • Intracranial Aneurysms: Treatment and Complications
  • Vascular Malformations Diagnosis and Treatment
  • Glioma Diagnosis and Treatment
  • Neurosurgical Procedures and Complications
  • Meningioma and schwannoma management
  • Traumatic Brain Injury and Neurovascular Disturbances
  • Intracerebral and Subarachnoid Hemorrhage Research
  • Advanced Glycation End Products research
  • Spinal Fractures and Fixation Techniques
  • Cerebrospinal fluid and hydrocephalus
  • Acute Ischemic Stroke Management
  • Moyamoya disease diagnosis and treatment
  • Head and Neck Surgical Oncology
  • Mycotoxins in Agriculture and Food
  • Immune cells in cancer
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Spinal Cord Injury Research
  • Cerebrovascular and Carotid Artery Diseases
  • Neuroblastoma Research and Treatments
  • Cancer, Stress, Anesthesia, and Immune Response
  • Spinal Hematomas and Complications
  • Wheat and Barley Genetics and Pathology
  • Spinal Dysraphism and Malformations
  • Neurofibromatosis and Schwannoma Cases
  • Spine and Intervertebral Disc Pathology

Sichuan University
2017-2025

Third Affiliated Hospital of Zhengzhou University
2023-2025

C.K. Tedam University of Technology and Applied Sciences
2024-2025

Weatherford College
2020-2024

West China Hospital of Sichuan University
2017-2023

Zhengzhou University
2023

Affiliated Hospital of Jiangsu University
2017-2022

Jiangsu University
2016-2022

Southeast University
2022

The First People's Hospital of Guiyang
2021-2022

Maize and its products are most often prone to fungal contamination especially during cultivation storage by toxigenic fungi. Aflatoxicosis still persist in Ghana despite the numerous education on several ways of prevention at farm as well adverse health implications which food safety concerns. A random assessment human risk analysis was conducted 90 maize (72 white 18 colored) samples from markets across all regions Ghana. Total aflatoxins (AFtotal) constitutive (AFB1, AFB2, AFG1, AFG2)...

10.1038/s41598-021-83751-7 article EN cc-by Scientific Reports 2021-02-22

A random assessment and human risk analysis were conducted on 80 groundnut pastes raw groundnuts from some local markets across the different agroecological zones of Ghana. Total aflatoxins (AFtotal) (AFB1, AFB2, AFG1, AFG2) analyzed using High-Performance Liquid Chromatography (HPLC) method. Out samples investigated, 49 (61.25 %) tested positive for AFB1 ranged 0.38 ± 0.04–230.21 22.14 μg/kg. The same proportion was recorded total between 0.02–270.51 23.14 Limits Ghana Standards Authority...

10.1016/j.toxrep.2021.01.002 article EN cc-by-nc-nd Toxicology Reports 2021-01-01

Purpose: This study aimed to evaluate the effects of irisin on bones ovariectomized (OVX) mice, explore a possible treatment for postmenopausal osteoporosis.Methods: The OVX mice were treated with intraperitoneal injections recombinant (r-irisin) or saline twice week 5 weeks. trabecular bone structure femur, strength tibia, and serum parameters assessed.Results: Treatment r-irisin prevented loss mice. r-irisin-treated exhibited greater microarchitecture, significantly increased mineral...

10.1080/13697137.2020.1745768 article EN Climacteric 2020-04-22

Abstract Background Chronic subdural hematoma (CSDH) is the anomalous and encapsulated accumulation of fluid complex origin consisting old blood, mostly or totally liquified cerebrospinal (CSF) in space usually after a head injury elderly. Almost all research on surgical techniques endoscopic assisted evacuation CSDH focused just not abnormal anatomical structures that causes recurrences. Objectives We investigated triggers recurrence during craniotomy as well burr-hole craniostomy with...

10.1186/s12893-022-01687-9 article EN cc-by BMC Surgery 2022-06-20

Abstract Background Medulloblastoma (MB) is a rare primitive neuroectodermal tumors originating from the cerebellum. MB most common malignant primary brain tumor of childhood. originates neural precursor cells in distinctive regions rhombic lip, and their maturation occurs cerebellum or stem during embryonal development. Also, apoptosis programmed cell death associated with numerous physiological as well pathological regulations. Recent Findings Irradiation (IR)‐induce triggers death,...

10.1002/cnr2.2048 article EN cc-by Cancer Reports 2024-04-01

"Huntington's disease" (HD) is an autosomal dominant hereditary neurodegenerative disease characterized by defects in efferent striatal neurons, cortical and the basal ganglia. The pathogenesis of HD still unclear, there currently no curative therapy for this disorder. This review emphasizes potential beneficial effects various neurotrophic factors HD. PubMed, Web Science, Embase, google scholar databases were used to search all studies on efficacy Several gene strategies have been employed...

10.2174/0115665232348486241025084202 article EN Current Gene Therapy 2025-01-01

Abstract: Glioma epitomizes exclusively primary brain cancer of glial cell or neuroepithelial derivation and irradiation (IR) is one the key standard treatment modalities for all kinds gliomas. Patients with glioma often undergo IR, such as whole-brain radiotherapy, stereotactic radiosurgery, well intensity modulated radiation therapy. However, IR therapy malignant still facing severe hindrances because gliomas have high resistance to IR. Autophagy a type II programmed death which has been...

10.2174/0118715206371143250402175030 article EN Anti-Cancer Agents in Medicinal Chemistry 2025-04-10

The treatment of severe traumatic brain injury (TBI) with herniation is challenging because outcomes are often associated high mortality and morbidity. Our aim was to identity factors contributing decompressive craniectomy (DC) evaluate in patients TBI herniation.In this retrospective study, we analyzed medical records from May 2009 December 2013. We reviewed their demographic data, mechanism injury, Glasgow Coma Scale (GCS) score, pupil status, computed tomography findings, surgical...

10.1097/md.0000000000022742 article EN cc-by-nc Medicine 2020-10-23

Clear cell meningioma (CCM) is an exceedingly rare subtype of meningioma, with spinal occurrences being even more uncommon. It predominantly affects children and characterized by a high recurrence rate poor prognosis, posing significant challenges for clinical treatment. Currently, gross total resection (GTR) the best approach to reduce improve prognosis in these patients. However, detailed descriptions intraoperative findings, particularly intraspinal cervical CCM, are scarce literature....

10.3389/fonc.2024.1505141 article EN cc-by Frontiers in Oncology 2025-01-10

Transsphenoidal endoscopic pituitary (TEP) tumor resection is performed through the nose via sphenoid sinus to remove tumors from gland. Also, enhanced recovery after surgery (ERAS) was adapted reduce physical and physiological traumatic stress response of surgical patients. A total 174 patients who underwent TEP in our department August 2021 June 2022 were randomly divided into non-ERAS group ERAS group. The main primary observational indicator postoperative self-care ability parameters...

10.1515/med-2025-1139 article EN cc-by Open Medicine 2025-01-01

Abstract: Neonatal brain injury (NBI) encompasses a variety of neurological acquired conditions affecting newborns. These include hypoxia-ischemia, hyperoxic, periventricular leukomalacia, intrauterine infection, as well perinatal cerebral hemorrhage. Each year, thousands babies are born with signs injury. It is estimated that two-thirds these newborn infants would either die or survive mild to severe neurologic sequelae, largely due the absence no widely accepted treatment methods....

10.2174/0115680266372339250418052436 article EN Current Topics in Medicinal Chemistry 2025-04-30

This study aimed to explore potential inflammatory biomarkers for early prediction of necrotizing enterocolitis (NEC) in premature infants.Plasma samples were collected from infants with NEC (n = 30), sepsis 29), and controls without infection 29). The 92 inflammatory-related proteins assessed via high-throughput OLINK proteomics platform.There 11 that significate differences (p < 0.05) among NEC, control preterm infants, which include IL-8, TRAIL, IL-24, MMP-10, CCL20, CXCL1, OPG, TSLP,...

10.1007/s00011-023-01702-6 article EN cc-by Inflammation Research 2023-02-18

Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. We identify High Mobility Group Box 1 (HMGB1) as novel causative factor in the development cerebral oedema, mediating coagulation, preventing secondary damage well serving therapeutic target to limit neurological after TBI. As prototypical danger associated molecular patterns (DAMP), HMGB1 released from necrotic neurons via NR2B-mediated mechanism during The secretion requires severe tissue hypoperfusion, with...

10.4236/jbbs.2017.72006 article EN Journal of Behavioral and Brain Science 2017-01-01

Abstract Objective This study aimed to test the hypothesis that levobupivacaine has anti-tumour effects on breast cancer cells. Results Colony formation and transwell assay were used determine cells proliferation. Flow Cytometry (annexin V PI staining) was investigate apoptosis. The of cellular signalling molecular response studied with Quantitative Polymerase Chain Reaction western blot. Induction apoptosis confirmed by cell viability, morphological changes showed shrinkage, rounding,...

10.1186/s13104-020-05191-2 article EN cc-by BMC Research Notes 2020-08-17
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