A5068732362- Anesthesia and Neurotoxicity Research
- Histone Deacetylase Inhibitors Research
- COVID-19 and Mental Health
- Ubiquitin and proteasome pathways
- Anesthesia and Sedative Agents
- Intensive Care Unit Cognitive Disorders
- Neuroscience and Neuropharmacology Research
- 14-3-3 protein interactions
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- SARS-CoV-2 and COVID-19 Research
- Sleep and Work-Related Fatigue
- Cancer Immunotherapy and Biomarkers
- COVID-19 and healthcare impacts
- Intraoperative Neuromonitoring and Anesthetic Effects
- Gastrointestinal Tumor Research and Treatment
- Muscle Physiology and Disorders
- Protein Degradation and Inhibitors
- Sleep and related disorders
- Botulinum Toxin and Related Neurological Disorders
- SARS-CoV-2 detection and testing
- NF-κB Signaling Pathways
- Anesthesia and Pain Management
- HER2/EGFR in Cancer Research
- Chemical Synthesis and Analysis
Shanghai Jiao Tong University
2022
Tongji Hospital
2007-2022
Huazhong University of Science and Technology
2007-2022
Cancer Hospital of Chinese Academy of Medical Sciences
2021
University of Virginia
2017-2021
Wuhan University
2020
Zhongnan Hospital of Wuhan University
2020
In-Q-Tel
2009
GTx (United States)
2009
To confirm the relationship between sex and progression of Coronavirus Disease-19 (COVID-19), its potential mechanism, among severe patients. For this retrospective study, we included 168 consecutive patients with pathogen-confirmed COVID-19 who were hospitalized January 16th February 4th, 2020, at Tongji Hospital in Wuhan, China. Clinical characteristics, laboratory parameters, outcomes compared analyzed males females. In present COVID-19, including 86 82 females, 48 (28.6%) diagnosed as...
Nurses' work-related fatigue has been recognized as a threat to nurse health and patient safety. The aim of this study was assess the prevalence among first-line nurses combating with COVID-19 in Wuhan, China, analyze its influencing factors on fatigue. A multi-center, descriptive, cross-sectional design convenience sample used. statistical population consisted 7 tertiary general hospitals from March 3, 2020 10, Wuhan China. total 2667 samples 2768 contacted participants completed...
To investigate the prevalence of insomnia among front-line nurses fighting against COVID-19 in Wuhan, China, and analyse its influencing factors.Insomnia is an important factor that can affect health work quality nurses. However, there a lack big-sample studies exploring factors COVID-19.This cross-sectional study using Ascension Insomnia Scale, Fatigue Scale-14 Perceived Stress Scale took place March 2020. Participants were 1,794 from four tertiary-level general hospitals.The participants...
Postoperative cognitive dysfunction (POCD) is a significant clinical issue. Its neuropathogenesis has not been clearly identified and effective interventions for use to reduce POCD have established. This study was designed determine whether environmental enrichment (EE) or (CE) reduces sex-determining region Y-box-2 regulated by sirtuin 1, plays role in the effect. Eighteen-month-old male mice were subjected right-common-carotid-artery exposure under sevoflurane anesthesia. Some of them...
The anaphase-promoting complex (APC) is a multisubunit E3 ubiquitin ligase that controls cell cycle transition in proliferating cells. Recent studies show Cdh1-APC active postmitotic neurons, which regulates axonal growth and patterning, synaptic development neuronal survival. However, the role of neural stem cells differentiation remains unknown. Using quantitative reverse transcription-PCR, we observed Cdh1 was expressed higher neurons than vitro. upregulated, whereas Id2 (one downstream...
Abstract Purpose: Several RAB family genes have been studied extensively and proven to play pivotal roles in the occurrence development of certain cancers. Here, we explored commonly expressed humans their prognostic significance using bioinformatics, then identified potential biomarkers breast invasive carcinoma (BRCA). Materials methods: The values (overall survival) BRCA were obtained Gene Expression Profiling Interactive Analysis (GEPIA). expression patterns relationships with...
BackgroundKidney renal clear cell carcinoma (KIRC) is the most common pathological subtype of cancer. APOBEC3 activity has been identified in a variety human cancers. Although its involvement cancer studied widely, influence on tumor immune microenvironment remains poorly understood. Therefore, this study aimed to focus effect KIRC.MethodsIn study, we comprehensively analyzed expression and prognostic significance family pan-cancer using multiple databases. The functions key members were...
As severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to disperse globally with worrisome speed, identifying amino acid variations in the virus could help understand characteristics of it. Here, we studied 489 SARS-CoV-2 genomes obtained from 32 countries Nextstrain database and performed phylogenetic tree analysis by clade, country, genotype surface spike glycoprotein (S protein) at site 614. We found that strains mainland China were mostly distributed Clade B undefined...
Paraplegia is a rare but terrible complication following major spinal operation. Intraoperative monitoring should be used to detect the neurological complications early so that they can surgically revised.1 The common procedures for cord are intraoperative wake-up test and neurophysiological methods. latter includes somatosensory evoked potentials (SSEP) motor (MEP). has been routinely monitor voluntary function of lower limbs during corrective surgery. During procedure, depth anaesthesia...
Objective To investigate the change in expression of excitatory amino acid transporter 3 (EAAT3) spinal cord neurons a rat model chronic morphine tolerance. Methods Forty-five male SD rats were randomly divided into 5 groups ( n = 9 each) : group I sham operation (group S); II normal saline NS); Ⅰ M); Ⅳ ketamine K) and groupV M + K. In - V catheter was placed subarachnoid space at L_(3-5) interspace. The animals observed for days. with motor or sensory paralysis hindlimbs excluded. NS 40...