A5027654063- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Gastric Cancer Management and Outcomes
- Viral gastroenteritis research and epidemiology
- Trauma and Emergency Care Studies
- Traditional Chinese Medicine Studies
- Colorectal Cancer Surgical Treatments
- Environmental Changes in China
- Remote Sensing and Land Use
- Bacteriophages and microbial interactions
- Acupuncture Treatment Research Studies
- Phytochemicals and Antioxidant Activities
- Pharmacological Effects of Natural Compounds
- Vitamin C and Antioxidants Research
- Vitamin D Research Studies
- Sepsis Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- Fermentation and Sensory Analysis
- Sperm and Testicular Function
- Regional Economic and Spatial Analysis
- Cancer, Hypoxia, and Metabolism
- Spondyloarthritis Studies and Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Horticultural and Viticultural Research
Soochow University
2024-2025
Second Affiliated Hospital of Soochow University
2024-2025
Center for Biologics Evaluation and Research
2021-2025
Northwest A&F University
2012-2025
Center for Drug Evaluation and Research
2025
Gilead Sciences (United States)
2020-2024
Yangtze University
2024
Philippine Women's University
2024
Army Medical University
2017-2023
Huazhong University of Science and Technology
2015-2023
Porcine reproductive and respiratory syndrome virus (PRRSV) is characterized by its extensive genetic diversity. Here we analyzed 101 sequences of NSP2 hypervariable region, 123 ORF3 sequences, 118 ORF5 from 128 PRRSV-positive clinical samples collected in different areas China during 2008–early 2012. The results indicated that the amino acid identities three genes among these were 87.6%–100%, 92.5%–100%, 77%–100%, respectively. Meanwhile, 4 novel patterns deletion insertion region or GP5...
Abstract As of April 26, 2020, more than 2,994,958 cases COVID-19 infection have been confirmed globally, raising a challenging public health issue. A predictive model the disease would help allocate medical resources and determine social distancing measures efficiently. In this paper, we gathered case data from Jan 22, 2020 to 14 for 6 countries compare different models’ proficiency in prediction. We assessed performance 3 machine learning models including hidden Markov chain (HMM),...
The SARS-CoV-2 spike protein is heavily glycosylated, having 22 predicted N-glycosylation sites per monomer. It also O-glycosylated, although the number of O-glycosites less defined. Recent studies show that glycans play critical roles in viral entry and infection. monomer has two subdomains, S1 S2, a receptor-binding domain (RBD) within domain. In this study, we have characterized site-specific glycosylation patterns HEK293 recombinant RBD domains as well intact derived from whole virus...
Some major challenges of ovarian tissue vitrification and transplantation include follicle apoptosis induced by cryopreservation ischemia-reperfusion injury, as well loss during post-transplantation. This research aimed to investigate the protective effects underlying mechanisms follicle-stimulating hormone (FSH) Sphingosine-1-phosphate (S1P) on vitrified post-transplantation ovaries. Ovaries from 21-day-old mice were with 0.3 IU/mL FSH, 2 µM S1P, FSH + respectively, for counting detection...
SARS-CoV-1 and MERS-CoV were the infective agents of 2002 2012 coronavirus outbreaks, respectively. Here, we report a comparative liquid chromatography/mass spectrometry (LC/MS) Orbitrap N- O-glycosylation glycoproteomics study recombinant S1 spike derived from these two viruses. The former was produced in HEK293 cells latter both insect cells. Both proteins highly glycosylated, with having 13 12 N-glycosites. Nearly all occupied at 85% or more. Between 2 113 unique N-glycan compositions...
Irritable bowel syndrome (IBS) significantly impairs the lifestyle and quality of life global population. However, underlying pathophysiological mechanisms remain largely elusive. While conventional pharmacological approaches show limited therapeutic efficacy, emerging microbiota-targeted dietary interventions present promising alternatives. The study aimed to elucidate molecular by which a synbiotic mitigates IBS associated colonic dysfunctions in C57BL/6 mice. mouse model was induced...
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus utilizes the extensively glycosylated spike (S) protein protruding from viral envelope to bind angiotensin-converting enzyme-related carboxypeptidase (ACE2) as its primary receptor mediate host-cell entry. Currently, main recombinant S production hosts are Chinese hamster ovary (CHO) and human embryonic kidney (HEK) cells. In this study, a truncated at transmembrane domain engineered express C-terminal trimerization motif...
Diabetic peripheral neuropathy (DPN) is one of the most common causes disability in diabetic population, and its pathogenesis related to a variety factors. There currently no effective treatment for such chronic disease. Traditional Chinese medicine has long clinical history prevention diabetes complications, it also shows certain advantages DPN. Many studies have confirmed that Huangqi Guizhi Wuwu decoction (HGWD) can reduce symptoms improve neuronal function patients with So we intend...
Liver injury is common and also can be fatal, particularly in severe or critical patients with coronavirus disease 2019 (COVID-19).To conduct an in-depth investigation into the risk factors for liver effective measures to prevent subsequent mortality risk.A retrospective cohort study was performed on 440 consecutive relatively COVID-19 between January 28 March 9, 2020 at Tongji Hospital, Wuhan, China. Data clinical features, laboratory parameters, medications, prognosis were...
Objective The purpose of this study was to explore the demands nurses on workplace environment related psychological resilience. Methods A qualitative descriptive design employed for study. Purposeful sampling chosen from a tertiary hospital in Henan Province, China. Semi-structured in-depth interviews were conducted with 20 nurses. interview data analyzed using Colaizzi’s method and results reported following COREQ standards. Results Analysis revealed three main themes: (1) Career Support...
Purpose The learning subjective well-being of high school students has significant value for their academic achievement and future life development. A growth mindset is one the key factors affecting students. However, research on mechanism by which a affects still relatively limited. Therefore, study aims to investigate impact students, as well role that motivation grit play serial mediators in this relationship. Methods This employed convenience sampling method select 708 from Chinese...
Novel coronavirus pneumonia (COVID-19) is a very serious and urgent infectious disease. With the development of global economy improvement living standard, incidence diabetes increasing year by year. And it more common in elderly. COVID-19 associated with much chronic disease, especially diabetes. At present, there no systematic review meta-analysis mortality based on large scale data between all over world.The databases PubMed, Cochrane Library, EMBASE, Wanfang Data, China National...
As severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to disperse globally with worrisome speed, identifying amino acid variations in the virus could help understand characteristics of it. Here, we studied 489 SARS-CoV-2 genomes obtained from 32 countries Nextstrain database and performed phylogenetic tree analysis by clade, country, genotype surface spike glycoprotein (S protein) at site 614. We found that strains mainland China were mostly distributed Clade B undefined...