A5045994478- HIV/AIDS Research and Interventions
- HIV, Drug Use, Sexual Risk
- Sex work and related issues
- Global Health Care Issues
- Health Systems, Economic Evaluations, Quality of Life
- Child and Adolescent Health
- Pharmaceutical studies and practices
- Pregnancy and preeclampsia studies
- Chronic Lymphocytic Leukemia Research
- Gestational Diabetes Research and Management
- Pharmaceutical Economics and Policy
- Asthma and respiratory diseases
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Blood Pressure and Hypertension Studies
- COVID-19 Clinical Research Studies
- HIV-related health complications and treatments
- SARS-CoV-2 and COVID-19 Research
- Rheumatoid Arthritis Research and Therapies
- Biosimilars and Bioanalytical Methods
- HIV Research and Treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pharmaceutical Practices and Patient Outcomes
- Vaccine Coverage and Hesitancy
- Hematopoietic Stem Cell Transplantation
Medical University of Sofia
2016-2025
Sofia University "St. Kliment Ohridski"
2024-2025
Faculty of Public Health
2015-2022
Public Health Department
2021
Alexandrovska Hospital
2020
Tokuda Hospital
2019
Acibadem City Clinic
2019
Military Medical Academy
2017
Bulgaria is among the European Union (EU) countries with highest burden of cervical cancers and life expectancy below EU average. The majority cancer cases (more than 95%) are caused by human papillomavirus (HPV). aim this retrospective, cost illness study to identify direct healthcare costs in from payer perspective calculate indirect associated years lost. Costs data were sourced National Health Insurance Fund January 2018 December 2020. Years lost calculated based on country...
We present the clinical course, and treatment of two consecutive cases neuroinvasive West Nile virus (WNV) infection in Clinic Intensive Care, an Care Unit (ICU) at Military Medical Academy - Sofia. Clinical epidemiological data, microbiological, laboratory, molecular methods, imaging techniques were used. Both patients resided Sofia, Bulgaria, had not travelled recent months. The first case was a 60-year-old man who have mental status changes, fever, progression existing Parkinson's...
Obesity is one of the risk factors for development socially significant diseases from group chronic non-communicable diseases, and obesity in women reproductive age particular pregnant an extremely important medico-social problem affecting both mother her child, indeed all modern society. In this article, influence some biological social determinants influencing problem, leading to changes trends medico-demographic health indicators serving assess public health, will be examined analyzed.
Fertility preservation and pregnancymanagement are critical considerations for patients undergoing organtransplantation. Innovations in assisted reproductive technologies, hormonalmodulation, personalized medicine have expanded options these patients, who face unique challenges due to immunosuppressive therapy organ functionconcerns. This mini-review explores advancements cryopreservationtechniques, pre-conception counseling, multidisciplinary strategies forsafe pregnancies...
Direct oral anticoagulants (DOACs) are used as a more effective and safe alternative to vitamin K antagonists, with simpler dosing strategy stable pharmacokinetic profile. However, existing data on individual variations in DOAC plasma levels suggest that determining on-treatment may be beneficial certain clinical situations. This study assesses the interindividual determines acceptable therapeutic ranges of apixaban rivaroxaban patients venous thromboembolism (VTE), including subgroup...
Background and Objectives: Over the past few decades, a substantial body of evidence has linked periodontitis to systemic diseases—including hypertension—but mechanisms underlying this association are not fully understood. This study aims identify factors that may mediate relationship, including an analysis inflammatory biomarker NLRP3 IL-1β levels in serum saliva patients with both diseases. Materials Methods: included 108 individuals (mean age, 47.8 years, SD 12.8), 38.9% male 61.1%...
The increased life expectancy of PLHIV (People Living with HIV) and the successful highly combined antiretroviral therapy (cART) poses new clinical challenges regarding aging its co-morbid condition. It is commonly believed that HIV infection "accelerates" aging. Human immunodeficiency virus type 1 (HIV-1) characterized by inflammation immune activation persists despite cART, may contribute to development conditions. In this regard, we aimed compare current cART regimens in light premature...
Knowledge of HIV status can be important in reducing the risk exposure. In a European sample men-who-have-sex-with-men (MSM), we aimed to identify factors associated with serostatus disclosure most recent anal intercourse (AI) partner. We also describe impact on exposure risks. During 2013 and 2014, 4901 participants were recruited for bio-behavioural Sialon-II study 13 cities. Behavioural data collected self-administered paper questionnaire. Biological specimens tested antibodies. Factors...
The objective of the study was to compare three different questionnaires (Short Form (SF)-6D, EuroQuol (EQ)-5D and WHO-5) establish which one is more sensitive gives an adequate assessment quality life in patients with diabetes. In observational transversal duration 4 months, 5 Bulgarian cities, 146 were randomly selected. following quality-of-life measuring instruments applied: SF-6D, EQ-5D 103 WHO-5. Descriptive statistics, chi-Square correlation coefficients used for data analysis....
Background and Objectives: Pregnancy introduces various interfering factors that, alongside individual variations, impact the assessment of thyroid function tests. This underscores necessity defining trimester-specific reference intervals for thyroid-stimulating hormone (TSH) levels. Differences in population characteristics, including ethnicity, socio-economic factors, iodine prophylaxis, obesity, emphasize need to establish TSH ranges women reproductive age respective region or center. The...
Reducing the number of people with undiagnosed HIV infection is a major goal control and prevention efforts in Europe elsewhere. We analysed data from large multi-city European bio-behavioural survey conducted among Men who have Sex (MSM) for previously infections, aimed to characterise MSM test less frequently than recommended.Data on sexual behaviours social characteristics Sialon II, cross-sectional 13 cities 2013/2014, were compared HIV-negative MSM. Based reported HIV-testing patterns,...
Data for MSM continue to show a high risk of acquiring HIV-STIs. Within this population, outness seems have an impact on both risk-taking and health seeking behaviors. The objective study was assess the relationship between socio-demographic, behavioral characteristics, testing behaviors, level among using data from multi-center bio-behavioral cross-sectional carried out in 13 EU cities. A multilevel analysis conducted identify factors associated with being open ("out") versus not ("in")....
COVID-19 demonstrates a different clinical severity of course in age groups. In the present study, we comparative analysis regarding risk hospitalization and in-hospital mortality between two extreme groups – children young adults (0-39 years) elderly patients (≥70 years). For period from January to June 2022, nasopharyngeal samples 1,611 at MHAT Uni Hospital (Panagyurishte, Bulgaria) were examined by PCR analysis, which 486 had positive result for SARS-CoV-2. From first target group with...
Hepatitis E virus is the major cause of non A enteral hepatitis. It usually transmitted by fecal oral route, but infection possible after bloodproducts transfusion and during birth. The medical literature data are controversial whether dialysis patients at higher risk infection. aim study was to investigate distribution HEV (seroprevalence) in hemodialysis from Pazardzhik region, Bulgaria. 102 (58.8% men 41.2% - women) on treatment were tested. mean age 58.7 years, women – 59.7. We used...
The aim of the study is to identify current practices self-medication in Bulgaria, estimate extent patients are influenced by information about safety OTC products and pharmacists’ role behavior process. An anonymous, questionnaire-based, descriptive was carried out among 280 pharmacists. majority (92.6%) ask for advice before buying products. Most often need drugs mild conditions (80.7%), save time (63.9%), because they unable consult a physician (61.9%). medium duration consultation an...
Background and objectives: To assess whether placental growth factor (PlGF) levels may have a predictive value for the onset of gestational diabetes mellitus (GDM) thyroid dysfunction during pregnancy. Materials Methods: This single-center retrospective analysis was conducted at Specialized Hospital Active Treatment in Obstetrics Gynecology "Dr. Shterev", Sofia, Bulgaria, from December 2017 to 2019. Using pregnant women's electronic records, we analyzed compared data 412 women diagnosed with...
The aim of the presented study was to compare efficacy three different retreatment techniques in removal gutta-percha and bioceramic-based sealer parts root canal.Extracted human single rooted teeth (n=66) were used.Teeth divided into six groups: Gr1retreated using ProTaper Universal Retreatment files after filling with central cone technique; Gr2 -ProTaper cold lateral compaction Gr3 -hand instruments
Retreatment of teeth filled with single cone technique and MTA based sealer – comparison the effectiveness different retreatment techniques (in vitro study), JofIMAB 2019 Jan-Mar;25(1):2379-2383