Russka Shumnalieva
A5055964580- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Systemic Sclerosis and Related Diseases
- MicroRNA in disease regulation
- Inflammatory Myopathies and Dermatomyositis
- SARS-CoV-2 and COVID-19 Research
- Cytokine Signaling Pathways and Interactions
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Autoimmune and Inflammatory Disorders Research
- COVID-19 Clinical Research Studies
- Peripheral Neuropathies and Disorders
- Bone and Joint Diseases
- Osteoarthritis Treatment and Mechanisms
- Immunodeficiency and Autoimmune Disorders
- Diabetes and associated disorders
- Bone health and osteoporosis research
- Spondyloarthritis Studies and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Pregnancy and Medication Impact
- Inflammasome and immune disorders
- Ocular Diseases and Behçet’s Syndrome
- Vasculitis and related conditions
- Long-Term Effects of COVID-19
- Muscle and Compartmental Disorders
Medical University of Sofia
2016-2025
Sofia University "St. Kliment Ohridski"
2024-2025
University Hospital St. Ivan Rilski
2016-2024
Center for Rheumatology
2014-2023
University of Zurich
2023
Background Since the publication of 2011 European Alliance Associations for Rheumatology (EULAR) recommendations patient research partner (PRP) involvement in rheumatology research, role PRPs has evolved considerably. Therefore, an update was deemed necessary. Methods In accordance with EULAR Standardised Operational Procedures, a task force comprising 13 researchers, 2 health professionals and 10 convened. The process included online meeting, systematic literature review in-person second...
COVID-19 vaccines have a favorable safety profile in patients with autoimmune rheumatic diseases (AIRDs) such as idiopathic inflammatory myopathies (IIMs); however, hesitancy continues to persist among these patients. Therefore, we studied the prevalence, predictors and reasons for IIMs, other AIRDs, non-rheumatic (nrAIDs) healthy controls (HCs), using data from two international Vaccination Autoimmune Diseases (COVAD) e-surveys.The first second COVAD patient self-reported e-surveys were...
Abstract Objective Flares of autoimmune rheumatic diseases (AIRDs) following COVID-19 vaccination are a particular concern in vaccine-hesitant individuals. Therefore, we investigated the incidence, predictors and patterns flares individuals living with AIRDs, using global Vaccination Autoimmune Diseases (COVAD) surveys. Methods The COVAD surveys were used to extract data on flare demographics, comorbidities, history, details for patients AIRDs. identified as patient-reported (a), increased...
The knee is the joint most frequently involved in osteoarthritis, a common disorder adult population that associated with significant chronic pain, reduced mobility and quality of life. Recent studies have established an association between obesity development osteoarthritis goes beyond increased mechanical load on knees as weight-bearing joints. This link based maintenance low-grade inflammation, altered secretion adipokines by adipose tissue sarcopenia. Major pathogenesis obesity-related...
Chimeric antigen receptor (CAR) T-cell therapy is a form of immunotherapy where the lymphocytes, mostly T-cells, are redirected to specifically recognize and eliminate target by coupling them with CARs. The binding CAR cell surface antigens leads vigorous T activation robust anti-tumor immune responses. Areas implication therapies include mainly hematological malignancies (i.e., advanced B-cell cancers); however, recent studies have proven unprecedented success new also in autoimmune...
Abstract Objectives Disease flares in the post–coronavirus disease 2019 (COVID-19) vaccination period represent a prominent concern, though risk factors are poorly understood. We studied these among patients with idiopathic inflammatory myopathies (IIMs) and other autoimmune rheumatic diseases (AIRDs). Methods The COVAD-1 -2 global surveys were circulated early 2021 2022, respectively, we captured demographics, comorbidities, AIRDs details, COVID-19 infection history details. Flares of IIMs...
Rheumatoid arthritis (RA) is an immune-mediated chronic and long-term condition that can lead to severe joint damage disability. It has been shown doctor–patient interaction communication have a significant impact on faster patient diagnosis treatment outcomes. Primary care (PC) the first level of contact with doctors health system. Communication between them often ineffective, leading delays in diagnosis, care, use disease-modifying antirheumatic drugs (DMARDs). The protocols standards for...
Fertility preservation and pregnancymanagement are critical considerations for patients undergoing organtransplantation. Innovations in assisted reproductive technologies, hormonalmodulation, personalized medicine have expanded options these patients, who face unique challenges due to immunosuppressive therapy organ functionconcerns. This mini-review explores advancements cryopreservationtechniques, pre-conception counseling, multidisciplinary strategies forsafe pregnancies...
Systemic sclerosis (SSc) is a chronic autoimmune connective tissue disorder characterized by three main pathological features: microangiopathy, immunological alterations, and excessive synthesis of extracellular matrix (ECM) proteins, leading to fibrosis the skin internal organs. Although etiology SSc still unknown, recent studies have revealed potential role genetic epigenetic factors in disease pathogenesis. They are involved regulation cell metabolism, hyperactivity, accumulation...
Abstract Limited evidence on long-term COVID-19 vaccine safety in patients with idiopathic inflammatory myopathies (IIMs) continues to contribute hesitancy. We studied delayed-onset adverse events (AEs) IIMs, other systemic autoimmune and disorders (SAIDs), healthy controls (HCs), using data from the second Vaccination Autoimmune Diseases (COVAD) study. A validated self-reporting e-survey was circulated by COVAD study group (157 collaborators, 106 countries) Feb–June 2022. collected...
Systemic necrotising vasculitides (SNVs) pose significant challenges due to their diverse clinical manifestations and variable outcomes. Therefore, identifying reliable biomarkers holds promise for improving precision medicine in SNVs. This review explores emerging aiming enhance diagnostic accuracy, prognostic assessment, disease monitoring. We discuss recent advances immunological biomarkers, inflammatory indicators, other parameters that exhibit potential utility. A comprehensive...
Abstract Background Despite the overall safety and efficacy of COVID‐19 vaccinations, rare cases systemic autoimmune diseases (SAIDs) have been reported post‐vaccination. This study used a global survey to analyze SAIDs in susceptible individuals' Methods A cross‐sectional was conducted among participants with self‐reported new‐onset using Vaccination Autoimmune Diseases (COVAD) 2 dataset—a validated, patient‐reported e‐survey—to long‐term vaccines. Baseline characteristics patients...
Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by autoantibody production, complement activation, and deposition of immune complexes in tissues organs. SLE can involve any region the visual system. Although ocular manifestations are not part classification criteria for SLE, they be observed up to one-third patients with SLE. They rarely reported at time onset. Retinal vasculitis usually associated active generalized disease. Due its low frequency, we report...
As part of European League against Rheumatism (EULAR)/European Musculoskeletal Conditions Surveillance and Information Network, 20 user-focused standards care (SoCs) for rheumatoid arthritis (RA) addressing 16 domains were developed. This study aimed to explore gaps in implementation these SoCs across Europe.Two cross-sectional surveys on the importance, level barriers (patients only) each SoC (0-10, 10 highest) designed be conducted among patients rheumatologists 50 countries. Care...
Objectives To describe and explore differences in formal regulations around sick leave work disability (WD) for patients with rheumatoid arthritis (RA), as well perceptions by rheumatologists on the system’s performance, across European countries. Methods We conducted three cross-sectional surveys 50 countries: one (re-)integration social security (SS) system arrangements case of long-term WD due to RA (one rheumatologist per country), two among approximately 15 country regarding SS...
We investigated coronavirus disease 2019 (COVID-19) vaccine safety in pregnant and breastfeeding women with autoimmune diseases (AID) the COVID-19 Vaccination Autoimmune Diseases (COVAD) study.