A5069163875- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Cardiovascular Function and Risk Factors
- Cardiac Valve Diseases and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Acute Myocardial Infarction Research
- Diabetes Treatment and Management
- Cardiovascular Disease and Adiposity
- Cardiac Structural Anomalies and Repair
- Cardiovascular Health and Disease Prevention
- Aortic aneurysm repair treatments
- Atrial Fibrillation Management and Outcomes
- Heart Failure Treatment and Management
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Mechanical Circulatory Support Devices
- Aortic Disease and Treatment Approaches
- Transplantation: Methods and Outcomes
- Coronary Artery Anomalies
- Peripheral Artery Disease Management
- Chronic Kidney Disease and Diabetes
- Advanced X-ray and CT Imaging
- Potassium and Related Disorders
- Vasculitis and related conditions
- Advanced MRI Techniques and Applications
- Infective Endocarditis Diagnosis and Management
Medical University of Sofia
2017-2025
Angel Kanchev University of Ruse
2023-2024
Cardiovascular Research Center
2022-2024
Alexandrovska Hospital
2019-2023
Onze Lieve Vrouwziekenhuis Hospital
2021-2023
Abstract Background The inflammatory response occurring in acute myocardial infarction (AMI) has been proposed as a potential pharmacological target. Sodium-glucose co-transporter 2 inhibitors (SGLT2-I) currently receive intense clinical interest patients with and without diabetes mellitus (DM) for their pleiotropic beneficial effects. We tested the hypothesis that SGLT2-I have anti-inflammatory effects along glucose-lowering properties. Therefore, we investigated link between stress...
To investigate in-hospital and long-term prognosis in T2DM patients presenting with acute myocardial infarction (AMI) treated SGLT2-I versus other oral anti-diabetic agents (non-SGLT2-I users).
A bolus thermodilution-derived index of microcirculatory resistance (IMR) has emerged as the standard for assessing coronary microvascular dysfunction (CMD). Continuous thermodilution recently been introduced a tool to quantify absolute flow and directly. Microvascular reserve (MRR) derived from continuous proposed novel metric function, which is independent epicardial stenoses myocardial mass.
Low fractional flow reserve (FFR) values after percutaneous coronary intervention (PCI) carry a worse prognosis than high post-PCI FFR values. Therefore, the ability to predict might play an important role in procedural planning. Post-PCI can now be computed from pre-PCI tomography angiography (CTA) using derived revascularization planner (FFRCT Planner). The aim of this study was validate accuracy FFRCT Planner. In multicenter, investigator-initiated, prospective study, patients with...
Sodium-glucose co-transporter 2 inhibitors (SGLT2-i) have shown significant cardiovascular benefits in patients with and without type diabetes mellitus (T2DM). They also gained interest for their potential anti-arrhythmic role ability to reduce the occurrence of atrial fibrillation (AF) ventricular arrhythmias (VAs) T2DM heart failure patients.To investigate in-hospital new-onset cardiac a cohort presenting acute myocardial infarction (AMI) treated SGLT2-i vs. other oral anti-diabetic agents...
Background: Coronary microvascular dysfunction (CMD) is an early feature of diabetic cardiomyopathy, which usually precedes the onset diastolic and systolic dysfunction. Continuous intracoronary thermodilution allows accurate reproducible assessment absolute coronary blood flow resistance thus allowing evaluation reserve (CFR) Microvascular Resistance Reserve (MRR), a novel index specific for function, independent from myocardial mass. In present study we compared resistance, CFR MRR...
Background Coronary artery disease (CAD) patterns play an essential role in the decision-making process about revascularization. The pullback pressure gradient (PPG) quantifies CAD as either focal or diffuse based on fractional flow reserve (FFR) pullbacks. objective of this study was to evaluate impact acute percutaneous coronary intervention (PCI) results considered surrogates clinical outcomes. Methods and Results This a prospective, multicenter patients with hemodynamically significant...
Background Development of left ventricle (LV) hypertrophy in aortic stenosis (AS) is accompanied by adaptive coronary flow regulation. We aimed to assess absolute flow, microvascular resistance, reverse (CFR) and resistance reserve (MRR) patients with without AS. Methods Absolute were measured continuous thermodilution 29 AS controls, AS, matched for age, gender, diabetes functional severity epicardial lesions. Myocardial work, total myocardial mass anterior descending artery (LAD)-specific...
Side branch predilatation (SBPD) during coronary bifurcation interventions is a technique that not recommended by the latest guidelines. However, data about clinical outcomes after SBPD are surprisingly few.
To validate a simplified invasive method for the calculation of index microvascular resistance (IMR).This is prospective, single-center study patients with chronic coronary syndromes presenting nonobstructive artery disease. IMR was obtained using both intravenous (IV) adenosine and intracoronary (IC) papaverine. Each measurement in duplicate. The primary objective agreement between acquired Secondary objectives include reproducibility time required measurement.One hundred sixteen...
Fractional flow reserve (FFR) pullbacks assess the location and magnitude of pressure drops along coronary artery. The pullback gradient (PPG) quantifies FFR curve provides a numeric expression focal versus diffuse artery disease. This study aims (1) to validate PPG using manual compared with motorized as reference; (2) determine intra- interoperator reproducibility derived from pullbacks. Patients stable disease an ≤ 0.80 were included. All patients underwent evaluation either device or...
Background Heart valve clinics (HVC) have been introduced to manage patients with valvular heart disease within a multidisciplinary team. Objective To determine the outcome benefit of HVC approach compared standard care (SOC) for moderate and asymptomatic severe aortic stenosis (mAS asAS). Methods Single-centre, observational registry mAS asAS at least one cardiac ambulatory consultation our Cardiovascular Centre. Based on outpatient strategy, were divided into group, if receiving visit HVC,...
Cardiac stress tests remain the cornerstone for evaluating patients suspected of having obstructive coronary artery disease (CAD). Coronary microvascular dysfunction (CMD) can lead to abnormal non-invasive tests.
Abstract Aims The leading reason for delayed discharge after pulmonary vein isolation (PVI) is vascular complications. This study aimed to evaluate feasibility, safety, and efficacy of the Perclose Proglide™ suture-mediated closure in ambulatory PVI, report complications, patient satisfaction, cost this approach. Methods results Patients scheduled PVI were enrolled prospectively an observational design. Feasibility was assessed as % discharged day procedure. Efficacy analysed acute access...