A5037276717- Ocular Diseases and Behçet’s Syndrome
- Systemic Lupus Erythematosus Research
- Retinal and Optic Conditions
- Vasculitis and related conditions
- Otitis Media and Relapsing Polychondritis
- Autoimmune and Inflammatory Disorders Research
- Rheumatoid Arthritis Research and Therapies
- Inflammasome and immune disorders
- Spondyloarthritis Studies and Treatments
- Autoimmune and Inflammatory Disorders
- Hepatitis C virus research
- Systemic Sclerosis and Related Diseases
- Sarcoidosis and Beryllium Toxicity Research
- Retinal Diseases and Treatments
- Oral Health Pathology and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Atherosclerosis and Cardiovascular Diseases
- Cerebral Venous Sinus Thrombosis
- Chronic Lymphocytic Leukemia Research
- Liver Disease Diagnosis and Treatment
- Fatty Acid Research and Health
- IgG4-Related and Inflammatory Diseases
- Cytomegalovirus and herpesvirus research
- Infectious Diseases and Tuberculosis
- Dermatological and Skeletal Disorders
Shariati Hospital
2015-2024
Tehran University of Medical Sciences
2015-2024
Zanjan University of Medical Sciences
2023
Qom University of Medical Science and Health Services
2021
Stanford University
2017-2019
Rheumatology Research Center
1993-2017
University of Tehran
1993-2015
Center for Rheumatology
2011
Hacettepe University
2010
Shahid Beheshti University
2006
Abstract Objective Behçet's disease ( BD ) is a chronic, relapsing, inflammatory vascular with no pathognomonic test. Low sensitivity of the currently applied International Study Group ISG clinical diagnostic criteria led to their reassessment. Methods An Team for Revision Criteria (from 27 countries) submitted data from 2556 clinically diagnosed patients and 1163 controls ‐mimicking diseases or presenting at least one major sign. These were randomly divided into training validation sets....
Abstract Background: Osteoarthritis (OA) is a cartilage degenerative process, involving the immune system, producing local inflammatory reactions, with production of pro‐inflammatory cytokines and metalloproteinases. No treatment still available to improve or reverse process. Stem cell therapy opened new horizons for many incurable diseases. Mesenchymal stem cells (MSCs) due their multi‐lineage potential, immunosuppressive activities, limited immunogenicity relative ease growth in culture,...
<h3>Background</h3> We aimed to describe the main features of Behçet9s disease (BD) in children largest prospective cohort date and propose a classification. <h3>Methods</h3> An international expert consensus group was formed define data set minimal symptoms for inclusion patients. Patients were entered prospectively during 66 months. Experts classified patients on basis. The concordance two classifications analysed confirmed with BD. Comparisons subgroups helped criteria. BD-associated...
Abstract Background: Ocular lesions, the main morbidity of Behcet’s disease (BD), are most difficult to treat. The aim this study was evaluate efficacy rituximab. Methods: Inclusion criteria were retinal vasculitis and edema, resistant cytotoxic drugs. Twenty patients randomized a rituximab group (RG) or combination therapy (CCTG). Rituximab given in two 1000‐mg courses (15‐day interval). Subjects received methotrexate (15 mg/weekly) with prednisolone (0.5 mg/kg per day). CCTG pulse...
Abstract Objective: To identify the clinical picture of Behcet’s disease in a large cohort patients (6500) Iran, over period 35 years, and compare them with other series from around world. Methods: Patients all Iran were seen Disease Research Unit by multidisciplinary team (rheumatologists, dermatologists, ophthalmologists). Diagnosis was based on ‘expert opinion’. Data collected standardized data sheet (105 items), stored an electronic database. updated at each follow‐up. Results: Male to...
Microvascular endothelial cells in the arterial adventitia have immunoregulatory function and build an instructive tissue niche for induction of pathogenic T giant cell arteritis.
This is an analysis of adult Behcet's disease (BD) in Iran, from the Iran Registry 7187 BD patients, gathered 1975 to 2014, among which 6075 were adults (84.5%).Patients seen by a multidisciplinary team experts. The diagnosis was expert opinion, not any specific classification/diagnosis criteria. However, 96.8% them classified International Criteria for Disease (ICBD). Adult BDs patients who had their first manifestation at age 16 or later.Males constituted 56% (male/female ratio 1.3/1)....
The effect of colchicine was evaluated in a large cohort Behçet's disease (BD) patients and compared to placebo. In randomized, double-blind, controlled crossover trial, 169 without major organ involvement were selected consecutively. They fulfilled the International Criteria for Disease. Patients randomly assigned or At 4 months, they swapped over (colchicine placebo, placebo colchicine) another months. primary outcome overall activity index, IBDDAM. secondary responses individual symptoms....
The effect of colchicine was evaluated in a large cohort Behçet's disease (BD) patients and compared to placebo. In randomized, double-blind, controlled crossover trial, 169 without major organ involvement were selected consecutively. They fulfilled the International Criteria for Disease. Patients randomly assigned or At 4 months, they swapped over (colchicine placebo, placebo colchicine) another months. primary outcome overall activity index, IBDDAM. secondary responses individual symptoms....
Independent replication of the findings from genome-wide association studies (GWAS) remains gold standard for results validation. Our aim was to test Behçet's disease (BD) with interleukin-10 gene (IL10) and IL-23 receptor-IL-12 receptor β2 (IL23R-IL12RB2) locus, each which has been previously identified as a risk factor BD in 2 different GWAS.Six haplotype-tagging single-nucleotide polymorphisms (SNPs) IL10 42 IL23R-IL12RB2 were genotyped 973 Iranian patients 637 non-BD controls. Population...
Objectives To identify new susceptibility loci for Behçet's disease (BD), we performed a genome-wide association study (GWAS) using DNA pooling. Methods Two replicate pools of 292 Iranian BD cases and 294 age- sex-matched controls were allelotyped in quadruplicate on the Affymetrix Genome-Wide Human SNP Array 6.0. Of 51 top markers, 47 technically validated through individually genotyping. Replication single nucleotide polymorphisms (SNPs) was an independent dataset (684 532 controls)....
Abstract Background The diagnosis of Behçet disease (BD) is challenging in many cases. purpose this study was to describe the clinical characteristics patients at a referral BD clinic. Methods In retrospective study, we collected data from national clinic November 2018–August 2019. A confirmed (BD group) or ruled out (Non-BD group), and two groups were compared for differences. Results total 238 satisfied inclusion criteria. Forty (16.8%) finally diagnosed with BD. Ocular genital lesions...
Objective. To set-up an international cohort of patients suspected with Behçet's disease (BD). The is aimed at defining algorithm for definition the in children. Methods. International experts have defined inclusion criteria as follows: recurrent oral aphthosis (ROA) plus one following—genital ulceration, erythema nodosum, folliculitis, pustulous/acneiform lesions, positive pathergy test, uveitis, venous/arterial thrombosis and family history BD. Onset <16 years, duration ≤3 future follow-up...
Abstract Aim: To evaluate the performance of new International Criteria for Behçet’s Disease (ICBD) in Iran. The ICBD was created 2006 to replace Study Group (ISG) criteria (created 1990). In this study, 14 existing diagnosis/classification (Curth, Hewitt, Mason and Barnes, Japan original, Hubault Hamza, O’Duffy, Cheng Zhang, Dilsen, revised, Group, Iran traditional, Classification Tree, revised Korea), were evaluated compared by calculating their sensitivity, specificity accuracy. Methods:...
Behcet's Disease (BD) is classified as a vasculitis, and progresses via attacks remissions. BD mainly seen around the Silk Road. The picture varies in different reports. For clinical descriptions, data from international cohort of patients (27 countries), will be used.Mucous membrane manifestations were oral aphthosis 98.1%, genital 76.9% patients. Skin 71.9% (pseudofolliculitis 53.6% erythema nodosum 33.6%). Ocular 53.7% (anterior uveitis 38.8%, posterior 36.9%, retinal vasculitis 23.5%)....
Objective: To analyze Behcet's Disease (BD) in Iran, from 1975 to 2018, and compare 35 large/small reports other countries.Methods: Patients all over when suspected, were sent the BD Unit. The diagnosis was done by expert opinion. All data recorded registry (updated each follow-up). are given percentage with 95% confidence Intervals.Results: mean age at onset 25.6 years. Standard deviation (SD) 9.8. disease duration 11.7 years (SD: 8.9). Males 55.8% (54.7-56.9), Females 44.2% (43.1-45.3),...
Objective The aim of this paper is to present the AutoInflammatory Disease Alliance (AIDA) international Registry dedicated Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic (VEXAS) syndrome, describing its design, construction, and modalities dissemination. Methods This a clinical, physician-driven, population- electronic-based instrument designed for retrospective prospective collection real-life data. Data gathering based on Research Electronic Capture (REDCap) tool intended obtain...