A5052595349- Ocular Diseases and Behçet’s Syndrome
- Systemic Lupus Erythematosus Research
- Retinal and Optic Conditions
- Vasculitis and related conditions
- Otitis Media and Relapsing Polychondritis
- Rheumatoid Arthritis Research and Therapies
- Autoimmune and Inflammatory Disorders Research
- Spondyloarthritis Studies and Treatments
- Musculoskeletal Disorders and Rehabilitation
- Osteoarthritis Treatment and Mechanisms
- Musculoskeletal pain and rehabilitation
- Cerebral Venous Sinus Thrombosis
- Autoimmune and Inflammatory Disorders
- Health Systems, Economic Evaluations, Quality of Life
- Monoclonal and Polyclonal Antibodies Research
- Hepatitis C virus research
- Inflammasome and immune disorders
- Spine and Intervertebral Disc Pathology
- Oral Health Pathology and Treatment
- Autoimmune Bullous Skin Diseases
- Retinal Diseases and Treatments
- Sarcoidosis and Beryllium Toxicity Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- T-cell and B-cell Immunology
- IgG4-Related and Inflammatory Diseases
Tehran University of Medical Sciences
2015-2024
Shariati Hospital
2013-2023
Iran's National Elites Foundation
2016-2022
Iran Khodro (Iran)
2016-2022
Rheumatology Research Center
1993-2021
Center for Rheumatology
2011-2021
University of Tehran
2004-2015
Iranian Orthopedic Association
2014
Hôpital Robert-Debré
2011
Shahid Beheshti University
2006
Abstract Objective Behçet's disease ( BD ) is a chronic, relapsing, inflammatory vascular with no pathognomonic test. Low sensitivity of the currently applied International Study Group ISG clinical diagnostic criteria led to their reassessment. Methods An Team for Revision Criteria (from 27 countries) submitted data from 2556 clinically diagnosed patients and 1163 controls ‐mimicking diseases or presenting at least one major sign. These were randomly divided into training validation sets....
Abstract Background: Osteoarthritis (OA) is a cartilage degenerative process, involving the immune system, producing local inflammatory reactions, with production of pro‐inflammatory cytokines and metalloproteinases. No treatment still available to improve or reverse process. Stem cell therapy opened new horizons for many incurable diseases. Mesenchymal stem cells (MSCs) due their multi‐lineage potential, immunosuppressive activities, limited immunogenicity relative ease growth in culture,...
Abstract Aim Osteoarthritis is a degenerative joint disease characterized by the destruction of cartilage. Mesenchymal stem cells ( MSC s) are found in low numbers normal cartilage, mainly superficial layer, acting as repairing agents. In OA , s seen larger numbers, but act chaotic and unable to repair The synovial membrane becomes inflamed interacts with Transplanted have ability normalize them, redirecting them their function. preliminary study, we showed that could improve knee four...
Abstract Background: Ocular lesions, the main morbidity of Behcet’s disease (BD), are most difficult to treat. The aim this study was evaluate efficacy rituximab. Methods: Inclusion criteria were retinal vasculitis and edema, resistant cytotoxic drugs. Twenty patients randomized a rituximab group (RG) or combination therapy (CCTG). Rituximab given in two 1000‐mg courses (15‐day interval). Subjects received methotrexate (15 mg/weekly) with prednisolone (0.5 mg/kg per day). CCTG pulse...
Journal Article EVALUATION OF DIAGNOSTIC ('CLASSIFICATION') CRITERIA IN BEHÇET'S DISEASE—TOWARDS INTERNATIONALLY AGREED Get access THE INTERNATIONAL STUDY GROUP FOR DISEASE, DISEASE Search for other works by this author on: Oxford Academic PubMed Google Scholar B. Wechsler, Wechsler France F. Davatchi, Davatchi Iran Y. Mizushima, Mizushima Japan M. Hamza, Hamza Tunisia N. Dilsen, Dilsen Turkey E. Kansu, Kansu H. yazici, yazici C.G. Barnes, Barnes UK Correspondence to Dr. C. G. Department of...
Abstract Objective: To identify the clinical picture of Behcet’s disease in a large cohort patients (6500) Iran, over period 35 years, and compare them with other series from around world. Methods: Patients all Iran were seen Disease Research Unit by multidisciplinary team (rheumatologists, dermatologists, ophthalmologists). Diagnosis was based on ‘expert opinion’. Data collected standardized data sheet (105 items), stored an electronic database. updated at each follow‐up. Results: Male to...
Historical Background . The ISG criteria for Behcet's, created in 1990, have excellent specificity, but lack sensitivity. International Criteria Behcet's Disease (ICBD) was 2006, as replacement to ISG. aim of this study compare their performance. and ICBD For oral aphthosis is mandatory. presence any two the following (genital aphthosis, skin lesions, eye positive pathergy test) will diagnose/classify patient BD. ICBD, vascular lesions were added, while no more Getting 3 or points BD 2...
This is an analysis of adult Behcet's disease (BD) in Iran, from the Iran Registry 7187 BD patients, gathered 1975 to 2014, among which 6075 were adults (84.5%).Patients seen by a multidisciplinary team experts. The diagnosis was expert opinion, not any specific classification/diagnosis criteria. However, 96.8% them classified International Criteria for Disease (ICBD). Adult BDs patients who had their first manifestation at age 16 or later.Males constituted 56% (male/female ratio 1.3/1)....
We recently identified a trinucleotide repeat polymorphism, (GCT)n, within the transmembrane (TM) segment of human MHC class I MICA gene (MHC chain‐related A). Five distinct alleles (A4, A5, A5.1, A6, A9) corresponding to 4, 5, 5 with one nucleotide insertion, 6 and 9 repetitions, respectively, have been detected in various HLA‐homozygous B cell lines. Here we present allele frequencies for this trimeric short tandem (STR) 604 unrelated individuals collected from nine populations (Japanese,...
The effect of colchicine was evaluated in a large cohort Behçet's disease (BD) patients and compared to placebo. In randomized, double-blind, controlled crossover trial, 169 without major organ involvement were selected consecutively. They fulfilled the International Criteria for Disease. Patients randomly assigned or At 4 months, they swapped over (colchicine placebo, placebo colchicine) another months. primary outcome overall activity index, IBDDAM. secondary responses individual symptoms....
The effect of colchicine was evaluated in a large cohort Behçet's disease (BD) patients and compared to placebo. In randomized, double-blind, controlled crossover trial, 169 without major organ involvement were selected consecutively. They fulfilled the International Criteria for Disease. Patients randomly assigned or At 4 months, they swapped over (colchicine placebo, placebo colchicine) another months. primary outcome overall activity index, IBDDAM. secondary responses individual symptoms....
Independent replication of the findings from genome-wide association studies (GWAS) remains gold standard for results validation. Our aim was to test Behçet's disease (BD) with interleukin-10 gene (IL10) and IL-23 receptor-IL-12 receptor β2 (IL23R-IL12RB2) locus, each which has been previously identified as a risk factor BD in 2 different GWAS.Six haplotype-tagging single-nucleotide polymorphisms (SNPs) IL10 42 IL23R-IL12RB2 were genotyped 973 Iranian patients 637 non-BD controls. Population...
Abstract Aim To calculate the epidemiology of Rheumatic Diseases in Iran. Materials and Methods The data Tehran, Zahedan, Sanandaj (urban) Tuyserkan (rural) stage Community Oriented Program for Control ( COPCORD ) studies were gathered. adjusted to population number studied areas represent Results Iran is 75 149 669 (71.5% urban areas, males 50.4%) mentioned area respectively 10 000 000, 580 071, 311 444 109 262. interviewed subjects 291, 1565, 2100 5830. Male/female ratio was 0.9/1, 0.8/1,...
Objectives To identify new susceptibility loci for Behçet's disease (BD), we performed a genome-wide association study (GWAS) using DNA pooling. Methods Two replicate pools of 292 Iranian BD cases and 294 age- sex-matched controls were allelotyped in quadruplicate on the Affymetrix Genome-Wide Human SNP Array 6.0. Of 51 top markers, 47 technically validated through individually genotyping. Replication single nucleotide polymorphisms (SNPs) was an independent dataset (684 532 controls)....
Spine-related disorders are a leading cause of global disability and burden on society to public health. Currently, there is no comprehensive, evidence-based model care for spine-related disorders, which includes back neck pain, deformity, spine injury, neurological conditions, spinal diseases, pathology, that could be applied in health settings. The purposes this paper propose: (1) principles transform the delivery care; (2) an globally; (3) implementation suggestions. Global Spine Care...