Daniela Opriş-Belinski
A5006694837- Rheumatoid Arthritis Research and Therapies
- Systemic Sclerosis and Related Diseases
- Systemic Lupus Erythematosus Research
- Spondyloarthritis Studies and Treatments
- Autoimmune and Inflammatory Disorders Research
- Salivary Gland Disorders and Functions
- Inflammatory Myopathies and Dermatomyositis
- Biosimilars and Bioanalytical Methods
- Monoclonal and Polyclonal Antibodies Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Psoriasis: Treatment and Pathogenesis
- Dermatologic Treatments and Research
- Inflammasome and immune disorders
- Connective Tissue Growth Factor Research
- Salivary Gland Tumors Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Ocular Diseases and Behçet’s Syndrome
- Vasculitis and related conditions
- Bone health and osteoporosis research
- Mast cells and histamine
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Pharmaceutical studies and practices
- Otitis Media and Relapsing Polychondritis
- Health Systems, Economic Evaluations, Quality of Life
- Diabetes and associated disorders
Carol Davila University of Medicine and Pharmacy
2016-2025
Clinical Emergency Hospital Bucharest
2016-2025
Mayo Clinic
2023
WinnMed
2023
Mayo Clinic in Florida
2023
Trakya University
2023
Second Hospital of Shanxi Medical University
2023
Shanxi Medical University
2023
Vall d'Hebron Hospital Universitari
2023
Marmara University
2023
Objectives To determine the causes of death and risk factors in systemic sclerosis (SSc). Methods Between 2000 2011, we examined certificates all French patients with SSc to death. Then developed a score associated all-cause mortality from international European Scleroderma Trials Research (EUSTAR) database. Candidate prognostic were tested by Cox proportional hazards regression model single variable analysis, followed multiple stratified centres. The bootstrapping technique was used for...
Background Low-dose glucocorticoid (GC) therapy is widely used in rheumatoid arthritis (RA) but the balance of benefit and harm still unclear. Methods The GLORIA (Glucocorticoid LOw-dose RheumatoId Arthritis) pragmatic double-blind randomised trial compared 2 years prednisolone, 5 mg/day, to placebo patients aged 65+ with active RA. We allowed all cotreatments except long-term open label GC minimised exclusion criteria, tailored seniors. Benefit outcomes included disease activity (disease...
Vitamin D has pleiotropic effects including immunomodulatory, cardioprotective, and antifibrotic properties is thus able to modulate the three main links in scleroderma pathogenesis. The aim of study was evaluate level vitamin patients with systemic sclerosis analyze associations between concentration features sclerosis.Fifty-one consecutive were evaluated for visceral involvement, immunological profile, activity, severity scores, quality life. status by measuring 25hydroxy-hydroxyvitamin...
Objective The aim of this paper is to present the AutoInflammatory Disease Alliance (AIDA) international Registry dedicated Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic (VEXAS) syndrome, describing its design, construction, and modalities dissemination. Methods This a clinical, physician-driven, population- electronic-based instrument designed for retrospective prospective collection real-life data. Data gathering based on Research Electronic Capture (REDCap) tool intended obtain...
The randomised placebo-controlled GLORIA (Glucocorticoid LOw-dose in RheumatoId Arthritis) trial evaluated the benefits and harms of prednisolone 5 mg/day added to standard care for 2 years patients aged 65+ with rheumatoid arthritis (RA). Here, we studied disease activity, flares possible adrenal insufficiency after blinded withdrawal study medication.Per protocol, successfully completing 2-year period linearly tapered stopped medication 3 months. We compared changes activity taper between...
Rheumatoid arthritis (RA) patients are at heightened risk of Coronavirus Disease-19 (COVID-19) complications due to immune dysregulation, chronic inflammation, and treatment with immunosuppressive therapies. This study aims characterize the clinical laboratory parameters RA diagnosed COVID-19, identify predictive factors for severe forms this infection patients, determine if any therapy is associated worse COVID-19 outcomes.
Clinical response in patients with rheumatoid arthritis (RA) treated biologic agents can be influenced by their pharmacokinetics and immunogenicity. The present study evaluated the concordance between serum drug antidrug levels as well clinical RA biological who experience first disease exacerbation while being on a stable treatment. 154 rituximab (RTX), infliximab (IFX), adalimumab (ADL), or etanercept (ETN) were included. DAS28, SDAI, EULAR assessed at baseline reevaluated precise time...
Rheumatoid arthritis (RA) is a chronic inflammatory disease of the joints affecting 1% world population. It has major impact on patients through disability and associated comorbidities. Current treatment strategies have considerably improved prognosis, but recent innovations (especially biologic drugs new class so-called "JAK/STAT inhibitors") important safety issues are very costly. Glucocorticoids (GCs) highly effective in RA, could reduce need for expensive with agents. However, despite...
Abstract Purpose of the present paper is to point out design, development and deployment AutoInflammatory Disease Alliance (AIDA) International Registry dedicated pediatric adult patients with Behçet’s disease (BD). The a clinical physician-driven non-population- electronic-based instrument implemented for retrospective prospective collection real-life data about demographics, clinical, therapeutic, laboratory, instrumental socioeconomic information from BD patients; based on Research...
Abstract Objectives To assess the lung involvement in patients with Still’s disease, an inflammatory disease assessing both children and adults. exploit possible associated factors for parenchymal these patients. Methods A multicentre observational study was arranged consecutive characterized by among those included AIDA (AutoInflammatory Disease Alliance) Network Registry. disease-lung defined presence of pleuritis, features, acute respiratory distress syndrome (ARDS), and/or pulmonary...
During the last decade, spondyloarthritis (SpA) has increasingly been considered a disease at crossroads between autoimmunity and autoinflammation. Some patients may even present with autoinflammatory-related manifestations, including fever, hidradenitis suppurativa, other neutrophilic dermatoses, an unusually high increase in inflammatory markers. Therefore, subgroup of SpA be identified, specific details about this cluster need to investigated. In regard, AutoInflammatory Disease Alliance...
Proteinuria, amyloidosis, and kidney failure are the main long-term renal complications of familial Mediterranean fever (FMF). This study assesses their risk factors, independent ethnicity or residence. Patients' data were drawn from International AIDA Network registry for monogenic autoinflammatory diseases. A total 598 FMF patients enrolled, with 80 having proteinuria, 61 25 failure. At multivariate regression analysis, proteinuria was associated out-of-flares thrombocytosis (OR: 4.78,...
The study aims to compare the efficacy and safety of biosimilar etanercept (SB4) original (ETN) in a real-life national cohort rheumatoid arthritis (RA).Data from RA patients were retrieved electronically Romanian Registry Rheumatic Diseases (RRBR), which contains all receiving biologics country.The included 242 with data after 6 months treatment: 123 (50.8%) ETN, 119 (49.2%) SB4. There no significant differences regarding composite scores activity between on ETN SB4 (e.g. DAS28 remission:...
Videocapillaroscopy is a simple, non-invasive investigation that allows the "in vivo" study of nailfold capillaries. This method inexpensive, easily accepted by patients and results can be interpreted. It mainly used in with Raynaud's phenomenon systemic sclerosis, but this examination also performed on who are suspected having microcirculation alterations, such as rheumatoid arthritis psoriatic arthritis. may aid diagnosis, evaluation prognosis other rheumatic diseases, besides sclerosis....
Objective Inflammation has been associated with an increased risk for cancer development, while innate immune system activation could counteract the malignancies. Familial Mediterranean fever (FMF) is a severe systemic inflammatory condition and also represents archetype of immunity deregulation. Therefore, aim this study to investigate development in FMF. Methods The ratio (RR) malignancies was separately compared between FMF patients fibromyalgia subjects, Still’s disease Behçet’s...
It was suggested that the immune system plays an important role at least in amplification of main elements systemic sclerosis (SSc), autoimmune disease with incompletely elucidated pathogenesis. Elucidation mechanisms involved interaction between T and B cells, major players system, could contribute to a better understanding some clinical pathological manifestations SSc. Recently, abnormalities Semaphorin 4D (Sema4D/CD100) or CD72, two contrareceptors cells cooperation, were associated...
The present manuscript aims to describe an international, electronic-based, user-friendly and interoperable patient registry for monogenic autoinflammatory diseases (mAIDs), developed in the contest of Autoinflammatory Diseases Alliance (AIDA) Network.This is electronic platform, based on Research Electronic Data Capture (REDCap) tool, used real-world data collection demographics, clinical, laboratory, instrumental socioeconomic mAIDs patients. instrument has flexibility, may change over...