A5072948533- Spondyloarthritis Studies and Treatments
- Rheumatoid Arthritis Research and Therapies
- Psoriasis: Treatment and Pathogenesis
- Autoimmune and Inflammatory Disorders Research
- Osteoarthritis Treatment and Mechanisms
- Systemic Lupus Erythematosus Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Liver Disease Diagnosis and Treatment
- Inflammatory Myopathies and Dermatomyositis
- Bone and Joint Diseases
- Musculoskeletal synovial abnormalities and treatments
- Health Systems, Economic Evaluations, Quality of Life
- Medical and Biological Sciences
- Bone health and osteoporosis research
- SARS-CoV-2 and COVID-19 Research
- Inflammatory Bowel Disease
- Musculoskeletal Disorders and Rehabilitation
- Healthcare Systems and Technology
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Hip disorders and treatments
- Chronic Disease Management Strategies
- Pharmaceutical studies and practices
- Vitamin D Research Studies
- Liver Disease and Transplantation
- Inflammatory mediators and NSAID effects
Universitat Autònoma de Barcelona
2016-2025
Corporació Sanitària Parc Taulí
2016-2025
Deleted Institution
2016-2025
Institute of Research and Innovation Parc Tauli
2016-2025
Centre for Biomedical Network Research on Rare Diseases
2024
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2024
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2024
Universitat de Barcelona
1992-2023
Center for Rheumatology
2001-2022
Oxfam
2020
Axial spondyloarthritis (axSpA) is a chronic inflammatory condition associated with considerable pain and impaired health-related quality of life (HRQoL) for affected patients. Despite the documented increase in healthcare resource utilization (HRU) related to axSpA, few studies have explored impact diagnostic delays on these outcomes. This study sought determine association between delay axial costs 3 years after diagnosis. retrospective, observational based routine follow-up data from...
The aim of our study was to analyse the serum interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta) and interferon-gamma (IFN-gamma) levels in patients with AS their relationship disease activity. An ELISA test used cytokine (IL-6, TNF-alpha, IL-1 IFN-gamma) 69 AS. Results were compared those from 43 RA 36 non-inflammatory back pain. between concentrations different cytokines parameters activity severity also evaluated. IL-6 TNF-alpha levels, but not...
Objective. The national registry of spondyloarthropathies (REGISPONSER) is launched to classify patients with this group diseases treated in Spanish rheumatology clinics. This manuscript describes the methodological and organizational background as well characteristics finally included, provides a comparative analysis between both ankylosing spondylitis undifferentiated spondyloarthropathy groups patients.
To assess HLA-B27 influence on the clinical phenotype of Ankylosing Spondylitis (AS) patients.An observational, cross-sectional and descriptive study AS patients from Spanish REGISPONSER database was performed. Demographic, clinical, disease activity (Bath Disease Activity Index (BASDAI), Bath Functional (BASFI), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP)), radiographic data Radiology (BASRI) score) were compared regarding status. A univariate multivariate analysis...
Abstract Objective Neovascularization, with an increased number of synovial vessels a characteristic morphology, seems to contribute the progression psoriatic arthritis (PsA). Accordingly, angiogenesis may be important therapeutic target in PsA. The aim this study was analyze effects infliximab on membrane patients PsA who responded therapy. Methods group comprised 9 were selected for presence active polyarthritis (including knee synovitis) despite methotrexate Clinical and biologic...
Recent genome-wide association studies (GWASs) have identified >20 new loci associated with the susceptibility to psoriasis vulgaris (PsV) risk. We investigated of PsV and its main clinical subphenotypes 32 having previous evidence (P < 5e−8) or strong GWAS 5e−5 in discovery P 0.05 replication sample) a large cohort patients (n = 2005) controls 1497). provide first independent for COG6 0.00079) SERPINB8 0.048) PsV. In those developed psoriatic arthritis 955), we found, time, IFIH1 0.013)....
SPIRIT head-to-head (H2H) is a 52-week (Wk) trial comparing ixekizumab (IXE) with adalimumab (ADA) for simultaneous American College of Rheumatology (ACR)50 and Psoriasis Area Severity Index (PASI)100 responses in 566 patients (distributed evenly across both groups) psoriatic arthritis (PsA). IXE was superior to ADA this primary end point at Wk24. We aimed determine the final efficacy safety results through Wk52 including prespecified subgroup analysis concomitant conventional synthetic...
To determine the first signs and symptoms, clinical, biological radiological characteristics of patients with early SpA.A total 150 SpA were selected from 2367 listed in REGISPONSER (Registro Español de Espondiloartritis la Sociedad Española Reumatología). The inclusion criterion was a disease course <or=2 yrs onset symptoms or appearance sign disease.Forty-six had AS, 51 psoriatic (Ps-SpA), 43 uSpA, 5 ReA, 4 IBD arthropathy 1 JCA. mean age at diagnosis higher Ps-SpA group (48.1 +/- 13.6...
Ankylosing spondylitis (AS) is a chronic inflammatory disease mainly affecting the axial skeleton and characterized by ossification of spinal disc, joints, ligaments leading to progressive ankylosis. Vertebral osteoporosis recognized feature AS. Studies have confirmed moderate high prevalence vertebral fractures with extremely varying ranges in patients Our objective was estimate representative Spanish population AS using validated semiquantitative method, MorphoXpress(®).Patients were...
Psoriatic arthritis (PsA) is a chronic inflammatory affecting up to 30% of patients with psoriasis (Ps). To date, most the known risk loci for PsA are shared Ps, and identifying disease-specific variation has proven very challenging. The objective present study was identify genetic specific PsA.We performed genome-wide association in cohort 835 1558 controls from Spain. Genetic tested at single marker level pathway level. Meta-analysis case-control 2847 individuals North America. confirm...
Adipokines are related to knee osteoarthritis, but their exact role is not well known. The aim of this study was evaluate the association between adipokines in synovial fluid and clinical severity patients with osteoarthritis joint effusion. Cross-sectional systematic inclusion female symptomatic primary ultrasound-confirmed Age, physical exercise, symptoms duration, classical cardiovascular risk factors different anthropometric measurements were collected. Metabolic syndrome defined...
Objectives First, to investigate if switching biological disease-modifying antirheumatic drugs (bDMARDs) after the failure prior bDMARD is efficacious in patients with axial spondyloarthritis (axSpA). Second, evaluate influence on this efficacy of (1) reason discontinue tumour necrosis factor inhibitor (TNFi), (2) changing type TNFi and (3) target. Methods A systematic literature review until January 2017 was performed using Medline, EMBASE Cochrane databases. Longitudinal studies assessing...
The objective was to determine if dose reduction is non-inferior full-dose TNFi maintain low disease activity (LDA) in patients already remission with TNFi, axial spondyloarthritis.Randomized, parallel, non-inferiority, open-label multicentre clinical trial. Patients were eligible they had spondyloarthritis and been for ≥ 6 months any available (adalimumab, etanercept, infliximab, golimumab) at the recommended by product labelling. randomized automated central allocation continue same...
Objectives To describe and compare the prevalence of comorbidities in female male patients with spondyloarthritis (SpA) to assess whether had a different impact on disease outcomes patients. Methods This is post hoc analysis COMOrbidities SPondyloArthritis study. Differences regarding sex were assessed using logistic regression models. Comorbidities evaluated for their (Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Score (ASDAS), Bath Functional Index, European health-related...
Abstract Objective To investigate whether the MEFV gene, which is involved in regulation of inflammatory response and has been associated with familial Mediterranean fever (FMF) intermittent hydrarthrosis, implicated pathogenesis palindromic rheumatism (PR) to examine its clinical presentation evolution a Spanish cohort PR patients. Methods Family histories, demographic data, laboratory characteristics 75 patients diagnosed as having were collected from medical records personal interviews....