A5012260090- Spondyloarthritis Studies and Treatments
- Rheumatoid Arthritis Research and Therapies
- Psoriasis: Treatment and Pathogenesis
- Autoimmune and Inflammatory Disorders Research
- Systemic Lupus Erythematosus Research
- Bone and Joint Diseases
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Biosimilars and Bioanalytical Methods
- Osteoarthritis Treatment and Mechanisms
- Atherosclerosis and Cardiovascular Diseases
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune cells in cancer
- Scoliosis diagnosis and treatment
- Systemic Sclerosis and Related Diseases
- Immunodeficiency and Autoimmune Disorders
- MicroRNA in disease regulation
- Advanced Radiotherapy Techniques
- Cytokine Signaling Pathways and Interactions
- Dermatology and Skin Diseases
- Breast Cancer Treatment Studies
- Musculoskeletal pain and rehabilitation
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Inflammasome and immune disorders
- Pharmaceutical studies and practices
- Asthma and respiratory diseases
Instituto Maimónides de Investigación Biomédica de Córdoba
2016-2025
University of Córdoba
2016-2025
Institute for Research in Biomedicine
2015-2024
Hospital Universitario Reina Sofía
2014-2023
Center for Rheumatology
2022
Cordoba University
2014-2021
Hôpital Cochin
2021
Inoue Hospital
2021
Hospital Reina Sofía de Murcia
2018-2020
Universidad Laboral de Córdoba
2018
Objectives. Although clinicians recognize hip involvement, which frequently leads to replacement surgery, as an important feature of AS, data on the epidemiology, nature disease and therapeutic strategies are scarce. We aimed describe epidemiology clinical radiological involvement define risk factors for surgery in AS patients.
BACKGROUND: The main objective of this study was to determine the efficacy intravenous (IV) iron sucrose therapy reducing transfusion requirements in elderly patients undergoing hip fracture surgery. STUDY DESIGN AND METHODS: This a prospective randomized controlled trial involving 200 Group A (100 patients) received standard treatment, while B (600 mg IV). primary endpoint number that were transfused postoperatively. secondary endpoints rate red blood cell units used, hematimetric variables...
To assess HLA-B27 influence on the clinical phenotype of Ankylosing Spondylitis (AS) patients.An observational, cross-sectional and descriptive study AS patients from Spanish REGISPONSER database was performed. Demographic, clinical, disease activity (Bath Disease Activity Index (BASDAI), Bath Functional (BASFI), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP)), radiographic data Radiology (BASRI) score) were compared regarding status. A univariate multivariate analysis...
To determine the first signs and symptoms, clinical, biological radiological characteristics of patients with early SpA.A total 150 SpA were selected from 2367 listed in REGISPONSER (Registro Español de Espondiloartritis la Sociedad Española Reumatología). The inclusion criterion was a disease course <or=2 yrs onset symptoms or appearance sign disease.Forty-six had AS, 51 psoriatic (Ps-SpA), 43 uSpA, 5 ReA, 4 IBD arthropathy 1 JCA. mean age at diagnosis higher Ps-SpA group (48.1 +/- 13.6...
Ankylosing spondylitis (AS) remains difficult to diagnose before irreversible damage sacroiliac joint is noticeable. Circulating microRNAs have demonstrated serve as diagnostic tools for several human diseases. Here, we analysed plasma identify potential AS biomarkers. Higher expression levels of microRNA (miR)-146a-5p, miR-125a-5p, miR-151a-3p and miR-22-3p, lower miR-150-5p, miR-451a were found in versus healthy donors. Interestingly, higher miR-146a-5p, miR-151a-3p, miR-22-3p was also...
Objective: Systemic lupus erythematosus (SLE) is associated to boosted atherosclerosis development and a higher cardiovascular disease risk. This study aimed delineate the role of anti-double stranded DNA (anti-dsDNA) antibodies on molecular profile activity immune vascular cells, as well their enhanced Approach Results: Eighty SLE patients were included. Extensive clinical/analytical evaluation was performed, including parameters (endothelial function, proatherogenic dyslipidemia, carotid...
To compare the clinical, demographic, and serologic characteristics treatment of patients diagnosed with ankylosing spondylitis (AS) from Europe (EU) Latin America (LA).We included 3439 national registries: Spanish Registry Spondyloarthritis (REGISPONSER), Belgian registry (ASPECT), American Spondyloarthropathies (RESPONDIA). We selected diagnosis AS who met modified New York classification criteria. Demographic, disease activity, functional, metrological measurement data were recorded....
Objective. Ankylosing spondylitis (AS) is generally observed in young patients but can occur later life or persons ≥ 50 years of age. Our objective was to characterize the clinical features late-onset AS a large multicenter national cohort. Methods. We studied National Registry Spondyloarthritis Spanish Society Rheumatology (REGISPONSER database) cohort (n = 1257), whom 3.5% had onset at age versus control group with < years. Results. There were no differences between and early-onset...
<h3>Background</h3> The advent of anti-TNFα drugs has considerably improved medical management in Rheumatoid Arthritis (RA) patients, although it been reported to be ineffective a fraction them. MicroRNAs (miRNAs) are small, non-coding RNAs that act as fine tuning regulators gene expression. Targeting miRNAs by gain or loss function approaches have brought therapeutic effects various disease models. <h3>Objectives</h3> To investigate serum miRNA levels during the induction therapy RA...
Objectives To characterise splicing machinery (SM) alterations in leucocytes of patients with rheumatoid arthritis (RA), and to assess its influence on their clinical profile therapeutic response. Methods Leucocyte subtypes from 129 RA 29 healthy donors (HD) were purified, 45 selected SM elements (SME) evaluated by quantitative PCR-array based microfluidic technology (Fluidigm). Modulation anti-tumour necrosis factor (TNF) therapy underlying regulatory mechanisms assessed. Results An altered...
Aims To explore the clinical and radiographical characteristics of axial psoriatic arthritis (PsA) to compare it with ankylosing spondylitis (AS) psoriasis. Methods Cross-sectional study from national multicentre registry REGISPONSER where participants fulfilled European Spondyloarthropathy Study Group spondyloarthritis criteria at entry. Clinical, laboratory between patients classified as PsA AS psoriasis by their rheumatologist are compared according HLA-B27 status. Results Of 2367 on...
Objective To explore the association between mobility, inflammation, and structural damage in ankylosing spondylitis (AS). Methods Patients with AS were included a cross‐sectional study which spinal mobility was measured by Bath Ankylosing Spondylitis Metrology Index (BASMI) University of Córdoba (UCOASMI), based on an automated motion analysis. Structural modified Stoke Spine Score (mSASSS), activity Disease Activity (ASDAS) (BASDAI). We analyzed correlations variables, as well interaction...
Several measurements are often used in daily clinical practice the assessment of Ankylosing Spondylitis (AS) patients. The Assessment SpondyloArthiritis International Society (ASAS) recommend its core set: chest expansion modified Schöber test, Occiput to wall distance, lateral lumbar flexion, cervical rotation and Bath Metrology Index (BASMI). BASMI also includes five measurements, some them recommended by ASAS. Three versions have been published with different scales intervals for each...
Radiographic axial spondyloarthritis (r-axSpA) is a chronic inflammatory form of arthritis in which tumor necrosis factor (TNF)-α, potent inducer response and key regulator innate immunity Th1 immune responses, plays central role. NETosis mechanism defense that involved diverse rheumatology diseases. Nevertheless, spontaneous generation r-axSpA, its association to disease pathogenesis, the involvement on anti-TNF-α therapy's effects has never been explored.Thirty r-axSpA patients 32 healthy...
Objectives: This study, developed within the Innovative Medicines Initiative Joint Undertaking project PRECISESADS framework, aimed at functionally characterize monocyte subsets in RA patients, and analyze their involvement increased CV risk associated with RA. Methods: The frequencies of subpopulations peripheral blood 140 patients 145 healthy donors (HDs) included study were determined by flow cytometry. A second cohort 50 30 HDs was included, which CD14+ CD16+ isolated using...
Background: This prospective multicenter study developed an integrative clinical and molecular longitudinal in Rheumatoid Arthritis (RA) patients to explore changes serologic parameters following anti-TNF therapy (TNF inhibitors, TNFi) built on machine-learning algorithms aimed at the prediction of TNFi response, based profiles RA patients. Methods: A total 104 from two independent cohorts undergoing 29 healthy donors (HD) were enrolled for discovery validation biomarkers. Serum samples...
This work aims to compare the interval cancer rate and characteristics between women screened with digital breast tomosynthesis (DBT) + mammography (DM) those DM alone.
Objective To compare the clinical and sociodemographic characteristics of Ibero-American patients with radiographic axial spondyloarthritis (r-axSpA) to those European patients, a particular focus on influence HLA-B27. Methods This was an observational, cross-sectional, multicentre study who fulfilled Spondyloarthropathy Study Group (ESSG) criteria for SpA from REGISPONSER RESPONDIA registries. Univariate multivariate analyses between populations stratified by HLA-B27 status were conducted....